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Biomedical subjects

R W Russell

Publications and source records attributed to R W Russell.

At least 163 records · Page 9Linked to original sources
PubMedDate not supplied

Duration of ischemia influences the development and resolution of ischemic brain edema.

The influence of the duration of ischemia on the development and resolution of post-ischemic brain edema (SG method) was studied in anesthetized rats. Edema developed during ischemia and the amount of edema was related to the duration of ischemia (r = 0.843, p less than 0.001). With recirculation to three hours, the major determinant of the amount of edema was still the duration of the preceding ischemia (p less than 0.001). Resolution of brain edema only occurred following fifteen minutes ischemia. Post-ischemic blood-brain barrier breakdown (14C-AIB, EB albumin) was greatest following longer ischemia. Where present, the BBB leakage was simultaneously to large and small molecules.

Animals↗
PubMedDate not supplied

Assessment by fluorescein angiography of surgical treatment of occlusive carotid artery disease.

Fundus fluorescein angiography was performed in 10 cases of occlusive carotid artery disease at presentation and after surgery or medical treatment. An improvement in the microcirculation of the retina was observed in 4 cases after carotid endarterectomy and in 1 case after carotid endarterectomy and extracranial-intracranial bypass. Improvement was not observed in 2 cases after extracranial-intracranial bypass alone or in 3 cases in which surgical intervention was not undertaken. Our results suggest that carotid endarterectomy is a more effective procedure than extracranial-intracranial bypass in improving retinal perfusion when compromised by ipsilateral carotid obstruction.

Arterial Occlusive Diseases↗