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Biomedical subjects

R W Raven

Publications and source records attributed to R W Raven.

At least 19 recordsLinked to original sources

Surgical oncology--theory and practice.

In viewing the broad imagery of oncology, it is seen as a multidisciplinary subject, and attention is focused initially on oncology philosophy, indicating major problems for solution. The position of surgical oncology is clearly delineated in clinical oncology as a major discipline with well-defined theory and practice, which is the main subject here. The foundations of the theory are the essential sciences for surgeons--surgical anatomy, physiology, and pathology, with surgical oncology now emerging as a multidisciplinary science. The basic sciences of surgical oncology, currently making valuable additions to oncology knowledge, are defined, and their relevance to the build-up of the theory is described. There must be a constant feedback of theory and practice. Major surgical operations are central in the practice component; the latter can be epitomized as rehabilitation and continuing care. Rehabilitation begins with diagnosis. The performance of oncological operations requires sound surgical judgment and superb technical ability. The surgical oncologist has an important role in rehabilitation and continuing care programmes. Education and training courses in the theory and practice of surgical oncology are developing for graduates who desire a career in this discipline.

General Surgery↗

Carcinogenic and possible mutagenic effects of stilboestrol in offspring exposed in utero.

The relevant literature has been reviewed and it appears that there is no doubt that in utero exposure to stilboestrol is related to the eventual development of vaginal adenocarcinoma in young females. Although cancer of other types are also prevalent, the incidence is not great and may be related to other types of drugs taken during pregnancy. The review attempts to correlate the genetic effects with the abnormal development, but on account of the scarcity of data such correlation is not possible. Further work on the genetic effects and the development of the lower genital tract in the female needs to be carried out.

Abnormalities, Drug-Induced↗

Lymphocyte transformation in newborns, women and those who had used oral contraceptives.

Lymphocyte transformation, utilizing the mitotic index parameter has been assessed in newborns' cord blood, adults and women who had been on oral contraceptives and their babies. The results show that the newborns' cord blood response is significantly higher to PHA when compared with the respective adults' response. No significant difference was observed between the women taking oral contraceptives and their respective controls.

Adult↗

Liver biopsy.

An account is given of the findings obtained with open liver biopsy in 111 patients with various diseases, including 78 with cholecystitis and colelithiasis where unsuspected liver pathology, including biliary cirrhosis, was found in 37 patients. An exact diagnosis of hepatic metastasis by biopsy has therapeutic importance in malignant diseases, and in some patients, particularly those with argent-affinoma, liver involvement is compatible with normal life for many years.

Aged↗