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Biomedical subjects

R W Morris

Publications and source records attributed to R W Morris.

At least 181 records · Page 10Linked to original sources
PubMed1979

Biochemical studies of taste sensation: binding to taste tissue of 3H-labeled monellin, a sweet-tasting protein.

Binding of 3H-labeled methylated monellin to taste receptor tissue was demonstrated in vitro. Preparation of bovine and human circumvallate (taste) papillae bound more of the ligand than did lingual and nonlingual epithelial preparations devoid of taste buds. Binding to the taste preparations saturated at high ligand concentrations. Furthermore, sugars and other sweet-tasting molecules appeared to compete to some extent with this sweet-tasting protein for its binding sites. These binding measurements of the intensity sweet-tasting protein monellin to taste receptor preparations help to establish the binding interactions as an initial step taste sensation.

Animals↗
PubMed1979

Pancoast tumor: the value of high dose radiation therapy.

Twenty-six patients with superior pulmonary sulcus (Pancoast) tumors were evaluated. Twelve patients were treated with high dose radiotherapy with NSD over 1 900 rets and 10 with NSD less than 1 900 rets. Four patients were treated with combined radiation and surgery. High dose radiotherapy resulted in relief of pain in all patients but apparently did not change survival. Low dose radiotherapy offered relief of pain to only half the patients. Distant metastasis was noted in 30% of patients (15% to brain, 3.8% to liver), rib destruction in 65% and supraclavicular nodes in 19%. Only 4 patients went to surgery and 2 died during operation. We thus conclude that Pancoast tumor is essentially an inoperable disease.

Adenocarcinoma↗
PubMed1979

Adriamycin and cis-dichlorodiammineplatinum in nonresectable and metastatic carcinoma of the lung.

The combination of adriamycin and cis-dichlorodiammineplatinum (DDP) was evaluated in 20 patients with nonresectable and metastatic carcinoma of the lung. Both drugs were administered at a dosage of 60 mg/m2 intravenously every 3 weeks. The overall objective response rate was 40% (eight of 20 patients) with two complete responses (CR) and six partial responses (PR). Four of eight patients with small cell carcinoma responded (1 CR and 3 PR) and four of 12 patients with nonsmall cell carcinoma responded (1 CR and 3 PR). The median duration of response was greater than 36 weeks. The median survival of responders was 54 weeks. Nausea and vomiting were major side effects but rarely lasted longer than 2 days. Renal and bone marrow toxicities were generally minimal and controlled by dosage reduction. However, there was one death secondary to severe myelosuppression.

Adenocarcinoma↗
PubMed1979

The use of linear models to investigate the "centre effect" on graft survival.

First cadaver graft survival at 90 days in six UK centres was analysed, and found to differ widely between the centres (p less than 0.0005). Linear models were used to test whether these differences could be explained by other factors known to influence graft survival, such as age of recipients, tissue typing, blood group matching or year of graft. Adjusting for these factors singly and in various combinations did not reduce the significance of the "centre effect". These results held good both when deaths with a functioning graft within 90 days were treated as exclusions and also when they were treated as graft failures.

Aging↗
PubMed1976

A simplified method of electrocardiogram interpretation.

A modified step test is described, suitable for office use with the performance of the effort electrocardiogram. The results of haemodynamic changes are briefly presented and the results of measurement of 104 ECGs are tabulated and graphed. It is shown that by using ECGs taken 6 minutes after effort with lead V6 and by measuring the slope angle of the S-T segment, all abnormal subjects can be distinguished from at least 95% of normal subjects. The presence of a plane segment plus an S-T slope angle of less than 6,5 degrees will totally separate normal subjects from those with myocardial ischaemia. The patient's history will usually be found to accord with the above.

Adult↗
PubMed1975

The value of the effort electrocardiogram.

The most useful single predictor of future coronary events, but independent of other risk factors, is an effort electrocardiogram indicating ischaemia. The double Master's test as currently used is apt to fail in this respect in 46% of patients with abnormal hearts. The history of stress testing is outlined and it is concluded that treadmill techniques using the S-T segment index represent a much-needed advance on other methods. A small percentage of false positives and false negatives still remains, even with the most sophisticated computer-assisted techniques, and the reasons for this are discussed.

Arrhythmias, Cardiac↗
PubMed1975

The physiology of exercise and its clinical implications in coronary heart disease.

Exercise conditioning is a safe, effective therapeutic weapon in coronary heart disease (CHD) if correctly applied. This correct application presupposes, as would be the case in other forms of medical or surgical management, that the prescriber has a thorough knowledge of the underlying pathophysiology, both of the disease and of the cure. The physiology of exercise in normal persons is described in some detail, since similar effects apply in CHD patients. The training phenomenon, too, is similar in CHD sufferers, although it is less extensive than in athletes. Lastly, the alterations in physiology by which the patient can expect to benefit, are discussed.

Adaptation, Physiological↗