Time course of gold-induced accumulation of copper and zinc and the effects of dimercaptosuccinate and cadmium on gold metabolism in rat kidney.
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Biomedical subjects
Publications and source records attributed to R W Mason.
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Tests for the detection of animals heterozygous for alpha-mannosidosis were undertaken on samples taken from 34,203 cattle registered with the Angus Society of Australia. Results indicates 1,836 (5.4%) of the animals were heterozygotes. Heterozygotes were detected in 214 (51%) of the herds examined.
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Thirty cows gained access to a heap of discarded seed of chou moellier that had been stored in a barn for 10 years. Within 24 h 2 cows were dead and one was acutely ill. The outstanding lesion was oedema of the wall of the rumen. The toxicity was attributed to damage to blood vessels in the rumen wall resulting in marked loss of fluid.
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Spherical organisms, with an average diameter of about 22 microns, were detected in the lungs of adult and pouched young hairy-nosed wombats (Lasiorhinus latifrons). Although infections of up to 640 X 10(3) organisms per cubic centimeter were detected, their presence produced only limited pathological change. In-vitro growth was obtained at 30 C but not at 37 C or 40 C. However, at the higher temperatures, typical chlamydospore spherules were produced by colonies initially grown at 30 c. This report presents the first record of adiaspiromycosis in Australia and in wombats.
A 2-week-old Angora kid goat developed diarrhoea and was treated with parenterally administered antibiotics and saline. The kid rapidly became moribund and died within 6 hours of the first signs of illness. No bacterial or viral agents were detected in the intestinal content. On histological examination large numbers of small haematoxylin-staining bodies were detected associated with the brush border of small intestinal enterocytes. Associated with these bodies there was variable shortening of intestinal villi, some congestion and focal leucocyte infiltration in the lamina propira of the villi and focal epithelial erosions, sloughing or cell transition to more immature enterocyte forms. The location and features revealed by light microscopy and scanning and transmission electron microscopy indicate these bodies are cryptoporidia.
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In 1979 and 1980, 23 and 29 cases of ovine colisepticaemia from 16 and 18 properties respectively were diagnosed. All cases but one were caused by Escherichia coli 078: NM (Non Motile). Mortality ranged from 1% to 5% with an age distribution of 3 to 12 weeks. Most cases occurred in October. Thirty-three of the isolates were tested against a wide range of antibiotics and all had similar sensitivity patterns. E. coli 078 was detected less frequently in rectal cultures than in bile, small intestinal or nasal cultures from colisepticaemic lambs. In addition, E. coli 078 was recovered more frequently from nasal than from rectal cultures of lambs dying from causes other than colisepticaemia in colisepticaemic flocks. These findings suggest that perhaps the nasal route may be the more important portal of infection in ovine colisepticaemia caused by E. Coli 078 organisms.
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The finding of small spherules in the lungs of two species of wombats from Tasmania is described. An histological examination of lung tissue caused adiaspiromycosis to be suspected and the etiological agent was thought to Chrysosporium parvum.
A cat fed free-living rats (Rattus norvegicus and Rattus rattus) passed coccidian oocysts 14 days after eating a R. norvegicus. These oocysts were morphologically similar to B. wallacei and rats and mice dosed orally and intraperitoneally with them developed Besnoitia cysts in various body tissues. This organism was shown to have an obligatory two-host cycle and it is considered to be B. wallacei. This represents the first recorded detection of B. wallacei in Australia and also the first record of a natural free-living intermediate host for B. wallacei.
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Sporocysts from tiger snakes (Notechis ater) produced thick-walled sarcocysts in laboratory rats (Rattus norvegicus). Ultrastructurally these organisms were identical with sarcocysts found in native rats, but were different from Sarcocystis singaporensis. Sarocystis murinotechis sp.n. is proposed for this parasite of rodents and tiger snakes. When naturally-infected rats were fed to kittens (Felis domestica), quolls (dasyurus viverrinus) and a masked owl (Tyto novaehollandiae) no sporocysts were detected in the faeces of these animals. Also, sporocysts from owls (T. novaehollandiae and Ninox novaeseelandiae) were not infective for rats (R. norvegicus).