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Biomedical subjects

R W Janzen

Publications and source records attributed to R W Janzen.

31 records · Page 2Linked to original sources
PubMed1978

Influence of the cortico-spinal system on cervical and lumbar motoneurons in the rat.

In rats the connections of cortico-spinal fibres to cervical and lumbar motoneurons were examined using epicortical stimulation techniques. In cervical motoneurons, the synaptic response started in nearly 50% of the units with a monosynaptically transmitted EPSP, was of short duration and proved to be very effective. In contrast to that, the synaptic sequence found in lumbar motoneurons consisted in a small oligosynaptic and a prominent polysynaptic part. The differences in cortico-motoneuronal linkage correspond well with the different types of motor performance in fore- and hindlimbs.

Action Potentials↗
PubMed1978

[Centralized system for EEG-diagnosis and EEG-monitoring in a neurologic intensive care unit (author's transl)].

A centralized EEG system installed in a neurologic intensive care unit is described. It is the first step to a computerized EEG monitoring which on the basis of conventional EEG recordings already permits a "brain monitoring" to some extent. It consists of a system for total EEG diagnosis which is connected with a central EEG laboratory via long-distance transmission lines, and of a system for EEG-monitoring which is part of the general beside monitor system. The possibilities of this system are demonstrated in monitoring of patients with epileptic seizures.

Aged↗
PubMed1977

[Problems of postthymectomy-syndromes, e.g. myasthenia gravis (author's transl)].

6 years after resection and postirradiation of an "asymptomatic" thymoma, myasthenia gravis developed in a 46 year old man which improved within 6 months following initiation of immunosuppressive therapy with azathioprine. In a 28 year old man with incomplete operative removal of a metastasizing malignant thymoma, a myasthenia gravis appeared 8 weeks after surgery, i.e. before irradiation of the tumor relics. Myasthenia improved upon irradiation of the tumor relics and was no longer demonstrable one year after onset of its clinical signs. During the whole period of manifestation of the myasthenia, antibodies to skeletal muscle were deomonstrated in the first case, while, in the second case, in which antinuclear factors were present in the serum throughout the course of the myasthenia, muscular antibodies were detected only prefinally, i.e. in a stage without clinical symptoms of myasthenia. A review of the literature indicates that myasthenia gravis is a particularly frequent event in postthymectomy-syndromes (e.g. polymyositis, thyreoiditis, lupus erythematosus, hematological and dermatological syndromes). In postthymectomy-myasthenia, latency of manifestation, clinical distribution and its course may be rather variable. The problems of diagnosis, immunology and therapy of postthymectomy-myasthenia are discussed and general conclusions concerning postthymectomy-syndromes are drawn.

Adult↗
PubMed1976

[Penicillamine-induced myasthenia in chronic rheumatoid arthritis (author's transl)].

A myasthenic reaction developed after an average latency of seven to eight months in 12 female patients (average age 51 years) treated with penicillamine for chronic rheumatoid arthritis. In most of them only the purely ocular form was noted, but generalisation of various degrees also occurred. When penicillamine had been discontinued the myasthenic signs were almost always fully reversible, recurring once again when treatment with penicillamine was started. In some instances a transitory symptomatic treatment with cholinesterase inhibitors was necessary. The occurrence of the myasthenic signs in these circumstances is probably similar to the anti-basal membrane nephropathy induced by penicillamine.

Adult↗