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Biomedical subjects

R W Jackson

Publications and source records attributed to R W Jackson.

At least 19 recordsLinked to original sources
PubMed1991

Lateral retinacular release for patellofemoral pain in the older patient.

Lateral release for patellofemoral pain was performed on 39 knees in 34 patients aged greater than or equal to 30 years. At a mean follow-up of 6 years, there were 56% good or excellent results. Only 20% of patients did not achieve any benefit from the procedure. Although these results may not be as good as in the younger patient, this low morbidity procedure is nevertheless useful in the management of the older patient with patellofemoral malalignment.

Adult↗
PubMed1991

Functional testing of braces for anterior cruciate ligament-deficient knees.

Previous studies into the efficacy of bracing anterior cruciate ligament (ACL)-deficient knees have lacked objective functional testing. In this study of function the authors compare the effectiveness of three custom-made and three off-the-shelf braces in stabilizing symptomatic, unilateral, chronic, non-reconstructed, ACL-deficient knees. Ten subjects randomly performed six functional tests with each of the six test braces. Knee function was evaluated both objectively and subjectively. Two customized functional braces (Generation II Polyaxial Knee Cage and Lenox Hill Derotation Brace) provided the most objective improvement during ACL-dependent activities and also the most subjective stability. Laterally hinged braces were as effective as the more commonly used double-hinged models. Based on this study, the authors recommend the use of laterally hinged customized functional braces in the nonoperative treatment of the symptomatic ACL-deficient knee.

Adolescent↗
PubMed1989

Meniscal and articular cartilage injury in sport.

The mechanisms of injury, methods of diagnosis, and management of meniscal and articular cartilage injuries of the knee are outlined. Emphasis is placed on early and accurate arthroscopic diagnosis and treatment. Partial meniscectomy or meniscal repair is the preferred treatment in the early stage. Lavage and debridement can be useful in degenerative arthritis at a later stage.

Arthroscopy↗
PubMed1986

Rhodopsin's amino terminus is a principal antigenic site.

Antisera and monoclonal antibodies to rhodopsin were examined for their binding specificity to rhodopsin by using peptides from the rhodopsin sequence as competitors for antibody binding to rhodopsin in an enzyme-linked immunoassay. Monoclonal antibodies tested were raised in mice against bovine and rat rhodopsin. Antisera tested were raised in sheep against bovine rhodopsin and in rabbits against human rhodopsin. Peptides were synthesized from the bovine rhodopsin sequences 2-32, 1-12, 13-23, 24-34, 5-11, 231-252 and 331-348 for use as competitors in the immunoassay. A mixture of soluble CNBr peptides, and the purified CNBr peptide representing the sequence 2-39 were also employed. The monoclonal antibodies were all anti-amino-terminal in their binding specificity, although each recognized slightly different regions of the amino terminus. Each of the three antisera was predominantly directed against rhodopsin's amino terminus. We conclude that the amino-terminal 30 or more amino acids, and particularly the amino-terminal 15 amino acids, represent a principal antigenic region of the rhodopsin molecule.

Amino Acids↗
PubMed1979

2-(Aminomethyl)-2-decarboxyprostaglandin F2 alpha type analogs.

The 2-(aminomethyl)-2-decarboxy analogs of prostaglandin F2 alpha (PGF2 alpha), (15S)-15-methyl-PGF2 alpha, 16-phenoxy-omega-tetranor-PGF2 alpha and 16,16-dimethyl-PGF2 alpha were synthesized. The amino analogs closely resemble the parent PGF2 alpha compounds as antifertility agents in the hamster.

Abortifacient Agents↗
PubMed1978

Synthesis of thromboxane B2 metabolites.

This paper reports the synthesis of 11-dehydrothromboxane B2 methyl ester (II), 15-dehydrothromboxane B2 methyl ester (III), 15-dehydro-13, 14-dihydrothromboxane B2 (XII) and 2,3-dinorthromboxane B2 methyl ester (XV). These compounds, as their free acids, have been reported to be thromboxane metabolites.

Methods↗
PubMed1978

Activation of the alternative complement pathway by a streptococcal lipoteichoic acid.

A glycerol lipoteichoic acid antigen from Streptococcus pyogenes 1-RP41 was found by rabbit erythrocyte hemolytic assay to activate the alternative complement pathway in human sera. Over a narrow concentration range of the teichoic acid, complement consumption was dose dependent, whereas at higher concentrations of the acid complement consumption could not be detected.

Antigens, Bacterial↗
PubMed1977

Effects of phosphate supplementation on intact and fractured femora of rats: a biomechanical study.

The production of a better and stronger healing bone has attracted the interest of many investigators in the past. Numerous substances have been used to increase both the strength and the rate of production of fracture callus. Recently phosphate, administered orally, has been suggested for this purpose. A biomechanical study was conducted with rat femora and variable doses of phosphate in this regard. Phosphate was found to benefit osteomalacic bones but to have no effect on normal bones and a toxic effect in high concentrations.

Alkaline Phosphatase↗
PubMed1976

Comparison of luteolytic effectiveness of several prostaglandin analogs in heifers and relative binding affinity for bovine luteal prostaglandin binding sites.

The relative binding affinities for both the prostaglandin (PG)E1 and PGF2alpha specific bovine luteal binding sites were determined for five PGE and fourteen PGF derivatives and analogs. Relative binding affinity was determined in vitro using membranes prepared from bovine corpora luteal (CL) obtained from the slaughterhouse. The parent structure of the analog was a dominant feature in determining the affinity for the respective PG binding site. Luteolysis was determined in cattle following intramuscular injection of various doses of prostaglandin once between days 6 and 14 after estrus and measuring CL regression by ovarian palpation per rectum, interval between injection and return to estrus and duration of the subsequent estrous cycle. A dose which was luteolytic was established for each of eight PGF-type compounds, and a dose which was not luteolytic was also established. There appeared to be limited association between the relative affinity for the PGF2alpha specific site in vitro and the estimated luteolytic dose range of these PGF analogs when tested in cattle. Differences in in vivo luteolytic potency for the compounds tested could not be explained by differences in binding affinity. Differences in metabolism and absorption may also be important in the determination of in vivo potency.

Animals↗