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Biomedical subjects

R W Henderson

Publications and source records attributed to R W Henderson.

At least 37 records · Page 2Linked to original sources
PubMed1979

Leaching of lead from ceramics.

The amount of lead leached from various glazed ceramic was determined by extraction with 5% acetic acid for one hour at 85 degrees C. All commercial ceramic items, both domestic and imported, were below the FDA standard of 7 mg/liter lead in the extractant. On the other hand, almost 60% of the domestic homemade ceramic items exceeded FDA standards. Comparison with previous studies show significant reduction in lead leaching from commercial ceramic containers. However, homemade ceramic items continue to pose a potential hazard of excessive lead release.

Ceramics↗
PubMed1978

Demonstration of traumatic hepato-pleural-cutaneous defect by 131I-rose bengal.

A 19-year-old man was shot in the right chest about 2 cm below the nipple; bloody fluid was drained through a chest tube. Two days later sero-sanguineous fluid tinged with bile was seen to drain from the wound site. 131I-rose bengal, injected intravenously, collected in the dome of the liver and drained into a collection bag placed over the wound site, thus identifying a hepato-pleural-cutaneous fistula, which was confirmed at surgery.

Adult↗
PubMed1978

Experimental and clinical trials of new 99mTc-labeled hepatobiliary agents.

Several new derivatives of lidocaine were synthesized and used to examine the intra- and extrahepatic bile ducts and gallbladder. Diisopropyl-IDA exhibited approximately twice the bile concentration of 131I-rose bengal during the first hour after injection. P-butyl-IDA also concentrates moderately well in the bile and has the added advantage of very low excretion into the urine (2%). It seems more effective than the other IDA derivatives at high bilirubin levels.

Bile Ducts↗
PubMed1978

Labeling of platelets with oxine complexes of Tc-99m and In-111. Part 1. In vitro studies and survival in the rabbit.

We have used both Tc-99m oxine and In-111 oxine to study the effects in the rabbit of various parameters on platelet labeling and the in vivo survival of platelets harvested by four different methods. For In-111 oxine, platelet labeling in saline produces much higher efficiencies (90%) than labeling in the presence of plasma (20%), with no significant shortening of in vivo survival (1% survival at 5.9 days). For Tc-99m oxine, labeling efficiencies are considerably lower (30%) and survival is shorter (1% survival at 3.8 days). For both radioagents, a 30-min labeling incubation at room temperature is suggested.

Animals↗
PubMed1978

Platelets labeled with oxine complexes of Tc-99m and In-111. Part 2. Localization of experimentally induced vascular lesions.

Using rabbit platelets harvested and labeled with either Tc-99m or In-111 oxine as described in Part 1, we have successfully imaged experimentally induced fresh venous thrombi and newly injured arterial intima. Visualization of lesions up to 6 hr old is striking. Thrombi and arterial damage 24 hr old, however, were usually not imaged successfully; nor were preformed platelet-poor arterial emboli. The varying rates of platelet deposition in vascular lesions of different ages and types account for these observations. Should human cells prove as effective, widespread clinical application is anticipated.

Animals↗
PubMed1977

An evaluation of 99mTc-labeled hepatobiliary agents.

Scintigraphic imaging of the hepatobiliary system has been significantly improved with the development of 99mTc-labeled compounds. Two of the most promising agents, pyridoxylideneglutamate and HIDA, each formed the basis for the development of a group of structural analogs. Condensation of pyridoxal with leucine and arginine (in place of glutamate) produced pyridoxylideneleucine and pyridoxylidenearginine. Since increasing the molecular weight and the lipid solubility of compounds tends to enhance their biliary excretion, several new IDA derivatives were synthesized by altering the lipophilic substituents on the ring of HIDA. The substitutions included ethyl and ethoxy groups as well as iodine. All compounds were compared with 131I-rose bengal using a baboon model that allowed blood, bile, and urine collection.

Acetanilides↗
PubMed1975

Lead extraction from aluminum.

The lead content of various aluminum samples was determined. The amount of lead was found to be in the range from 28-45 ppm. The leaching of lead from aluminum products by 5% acetic acid was negligible at room temperature, but up to 2 mg/liter was leached at 85 degrees C. Although no significant health hazard exists in the usage of aluminum in contact with food items, it is recommended that aluminum containers be conditioned by several extractions with dilute acetic acid at higher temperatures.

Acetates↗