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Biomedical subjects

R W Grover

Publications and source records attributed to R W Grover.

9 recordsLinked to original sources
PubMed1984

The association of transient acantholytic dermatosis with other skin diseases.

A retrospective study of 375 patients with transient acantholytic dermatosis (TAD) showed significant statistical associations between TAD and asteatotic eczema, allergic contact dermatitis, atopic dermatitis, and irritation from adhesive tape, and these associations were believed to be clinically significant. A similar statistical correlation between TAD and the presence of skin cancer was not deemed significant on clinical grounds. There was a clinical suggestion of an etiologic relationship between TAD and bullous pemphigoid, but this was not demonstrated statistically. Most of these associations seem explicable in terms of the Koebner phenomenon, and it is suggested that prevention and treatment of eczematous inflammation and irritation of the skin may be helpful in the management of TAD.

Acantholysis↗
PubMed1976

Dermal changes in osteoporosis following prolonged treatment with human growth hormone.

Five patients with osteoporosis were treated with human growth hormone (hGH) for a year and the changes in their skin were studied by light and electron microscopy. The abnormally thin skin of osteoporosis appeared to change towards normal after treatment with hGH. There was a consistent proliferation of blood vessels, and increased number of mast cells and fibrocytes. The collagen bundles and elastic tissue fibers appeared hyperplastic and more horizontally oriented. The fine, vertical elastic fibrils of the papillary dermis had appeared decreased before treatment, but seemed to be restored to their normal configuration after treatment. Since there was no evidence of stimulation of hair, sebum, or melanin such as occurs in acromegaly, it is suggested that the scope of the direct action of hGH on the skin is limited to mesenchymal structures.

Aged↗
PubMedDate not supplied

Evaluation of platelet damage in extracorporeal circuits using a visual platelet morphology method.

Platelet damage in extracorporeal circuits occurs as the result of contact with foreign surfaces, shear stress, gas interface, and other nonphysiologic conditions. A scoring method developed to determine platelet activation was modified for evaluating platelet damage in extracorporeal circuits. This method assigns a numerical score to platelet damage, as assessed by direct visualization with phase microscopy. Various commercially available blood oxygenators were tested by using a modified AAMI/ASAIO in vitro blood trauma protocol. Direct gas contact oxygenators showed a marked decrease in total platelet count and significant platelet damage. Platelet depletion and platelet damage were lower in membrane oxygenators than in direct gas contact oxygenators. Differences in platelet damage were observed between membrane oxygenators. The observed differences between devices demonstrate the influence of materials and hemodynamic design on platelet depletion and damage. The method developed allows quantitative evaluation of platelet damage caused by extracorporeal devices and is a sensitive indicator of lethal and sublethal trauma.

Blood Flow Velocity↗