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Biomedical subjects

R W Griffiths

Publications and source records attributed to R W Griffiths.

At least 55 records · Page 3Linked to original sources
PubMed1983

Observations on the activity of the renin-angiotensin-aldosterone (RAA) system after low volume colloid resuscitation for burn injury.

Studies of plasma renin activity (PRA) and plasma aldosterone in burn patients treated with a low volume colloid resuscitation regimen revealed very high levels of both hormones. Highest hormone levels occurred in the 5 days post burn with the correlation between PRA and plasma aldosterone r = +0.787 (p less than 0.001). The negative correlation between 24 hour urinary sodium excretion and PRA (r = +0.671, p less than 0.001), was closer than that between 24 hour sodium excretion and plasma aldosterone (r = -0.556, p less than 0.01). Secondary elevations of PRA and plasma aldosterone occurred in 2 patients (7-14 days after injury) associated with clinical deterioration and systemic sepsis.

Adolescent↗
PubMed1982

Human dermal collagen allografts: a three year histological study.

A three year study of the histological appearances of glutaraldehyde treated human fibrous dermal collagen allografts is reported. There was no immune or inflammatory response and no fibrous capsule was noted. The implants were colonised by host fibroblasts and blood vessels. No collagen resorption was observed. This type of preparation may offer an alternative to autogenous dermis grafts, with the advantages that it is both cell free and does not cause donor site scarring.

Calcinosis↗
PubMed1982

Burn appearance and spontaneous healing: a prospective study.

In a prospective study to correlate initial burn wound appearance with burn wound appearance after 21 days of conservative wound care, it was found that all burn appearances (except the presence of thrombosed capillaries and charred, "leathery" skin) were associated with a high probability of spontaneous healing. These findings emphasize the difficulty of selecting those burn wounds likely to benefit from early excision and grafting unless, of course, the burn is obviously full-thickness.

Adolescent↗
PubMed1981

A low volume burn resuscitation regimen: assessment of performance by probit analysis.

The findings are presented of a 10-year retrospective review of burn admissions to the Wessex Regional Burn Centre, where a low volume colloid resuscitation regimen is employed. An analysis of mortality probability has been conducted using probit analysis, and the areas of burn injury associated with a 50 per cent mortality probability (LA50) were determined for four different age groups. LA50 values obtained were 0-14 years 59 per cent body surface area (BSA) burn, 15-44 years 70 per cent BSA burn, 45-64 years 38 per cent burn, 65 years and over 17 per cent BSA burn. The figures obtained parallel closely those reported from another large burn centre in the United Kingdom where a widely different fluid regimen is used. The results of this analysis suggest that wide variations in fluid resuscitation regimens, particularly with regard to volume, do little to affect the mortality associated with burn injury as assessed by probit analysis.

Adolescent↗
PubMed1981

The influence of postoperative pharmacological vasodilator agents on the pattern of necrosis in a standardised rat skin flap.

An experimental dorsal rat skin flap which produces a consistent pattern of necrosis is described. As judged by the area of necrosis in this flap, short post-operative courses and several vasodilator agents failed to increase flap survival. However it is not possible to conclude from this that those agents did not influence small vessel blood flow. Necrotic flaps in rats may not be the most appropriate models in which to test the effect of vasodilator agents.

Animals↗
PubMed1981

A burn formula in clinical practice.

In a retrospective review of the 10-year period 1969-78 the intravenous plasma loads given to patients admitted to one burn centre were studied and compared with the volumes predicted by the formula used at that centre. Of 1728 patients admitted 342 (19.8%) received intravenous resuscitation with plasma. The formula appeared to be a good empirical guide to transfusion needs in the 36 h after burning. Patients with burns in excess of 45% body surface area (BSA), and particularly children, were likely to require more fluid than that indicated by the formula estimate. However, as burns in excess of 50% BSA are uncommon (50/1728 admissions) it seems reasonable to use a formula which is a guide to the probable needs of most patients while accepting the clinical response as the best means of assessing the actual fluid need of each patient, especially those with extensive injury.

Adolescent↗
PubMed1980

Skin biopsy.

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Biopsy↗