[In vitro permeation studies with natural (animal) membranes. 2. Stability studies and influence of non-ionic tensides on permeation].
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Biomedical subjects
Publications and source records attributed to R Voigt.
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The effects of diazepam and phenytoin on penicillin-induced EEG changes and convulsions were studied in 32 rabbits. EEG changes and convulsions were elicited by 2.4 g/kg benzylpenicillin i.v. over 50 min. The dosages of the anticonvulsants were 1, 5 and 10 mg of diazepam and 10, 20 and 30 mg/kg of phenytoin. The qualitative and semiquantitative evaluation of the electroencephalograms revealed no reduction of spike frequency or spike amplitude for either of the two drugs. However, in contrast to phenytoin, diazepam was highly effective in preventing the development of generalized convulsions. None of the 12 diazepam-treated animals developed a convulsion, whereas in most of the phenytoin treated animals and in most of the controls generalized convulsions appeared. The results suggest that diazepam should be used in the treatment of penicillin-encephalopathy.
The left kidneys of rabbits were fractionally irradiated to a total dose of 6.000 R. Renal function was regularly monitored by isotope nephrography. Semiquantitative measurements (Zum Winkel) and comparison to the two sides (Bargon and Emrich) show changes in renal function in the functional and excretory phases; these, however, were less marked than after single dose irradiation. The results are discussed with reference to the relevant literature.
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By means of isotope nephrograms of a total of 31 renally healthy pregnant women of the different thirds of pregnancy, the changes of renal function are investigated. The semiquantitative assessment is done according to zum Winkel. The results are discussed referring to the literature. The isotope nephrography proves to be a good screening test for the separate estimation of the function of both kidneys also in pregnancy.
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On the basis of the case material of the Universitäts-Frauenklinik Jena, in a prospective investigation 524 women with an interruption in 1972 are investigated for subsequent premature births and abortions. In a second study we retrospectively analyzed the anamnestic data of 133 females whose pregnancies in 1974 ended with a premature birth. The results presented in tables are compared with suggestions from literature.
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