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Biomedical subjects

R Vock

Publications and source records attributed to R Vock.

At least 37 records · Page 2Linked to original sources
PubMed1987

[Macro- and microscopic findings of cord marks in 2 cases of delayed death by hanging].

Two cases of delayed death after suicidal or accidental hanging are reported. Despite equally long survival times (33 and 27 days, respectively) and macroscopically very similar cord furrows, segmental granulation tissue was present histologically in one case (suicide) below the cord furrow, and in the other case there was a normal corium. The main cause for the divergent ultrastructural findings consists in the variable degree of strangulation.

Accidents, Home↗
PubMed1986

[Marfan syndrome. A contribution to forensic medicine cases].

A 19-year-old school boy suffered from fluctuating uncharacteristic chest pain in the last 20 h before his death. He died unexpectedly within a few minutes of a hemopericardium, which resulted from an aneurysmal rupture of the ascending aorta. The patient's past history as well as the autopsy and ultrastructural findings led to the diagnosis of Marfan's syndrome with alterations of the cardiovascular skeletal system but no ophthalmological involvement ("oligosymptomatic" form of Marfan's syndrome). Appraisal of the cause of death is made more difficult by the fact that medical treatment was undertaken on the same day, whereby subtotal liver crushing was established that had resulted from attempts at resuscitation.

Adult↗
PubMed1985

[Fatal hemorrhage from ruptured varicose veins of the sigmoid colon in liver cirrhosis].

A 41-year-old woman died within a few hours one morning due to massive rectal hemorrhage. At autopsy, complete liver cirrhosis, signs of portal hypertension, liquid blood in the entire colon, and high-grade anemia were detected. The source of bleeding was a ruptured submucosal varix in the sigmoid colon, which was almost invisible even microscopically and had been caused by portal hypertension. In the vicinity, and somewhat further away from the rupture site, numerous, greatly dilated veins with wall sclerosis and intimal thickening, as well as paravascular iron deposits, were found as indications that severe hemorrhages had already occurred earlier. To detect the source of bleeding, meticulous inspection and dissection with hematoxylin and eosin, elastica van Gieson, and iron staining, were necessary.

Adult↗
PubMed1985

[Distribution of elastic bodies (elastic globes) in healthy human skin. Studies with a dense grid].

Since the turn of the century, there have been descriptions of corpuscular structures in the human skin. These are situated at the epidermal-corial junction zone. They can be visualized well with resorcinol-fuchsin staining according to Weigert. They may attain forensic significance in the topographic assignment of isolated skin fragments to certain body regions. The research results available so far, which are in some cases contradictory, were checked and the investigations were continued. A total of 584 skin punch samples were taken from the trunk and limbs of a 39-year-old male corpse. Of these, a total of 1752 paraffin serial sections (resorcinol-fuchsin staining) were prepared and investigated for the occurrence of elastic bodies. The investigation essentially showed that in almost all serial sections, elastic bodies were found to have a frequency concentration at points on the limbs. It could not be established that there was a sharp separation of skin areas containing elastic globes and skin areas free of elastic globes. The distribution of elastic bodies is evidently subject to a pattern of its own, which does not display any interrelationships with that of the skin appendages (apocrine and eccrine sweat glands, sebaceous glands, and male body hair). Because the skin of the trunk and the limbs is relatively regularly interspersed with elastic globes, there can only be used in connection with other features (e.g. thickness of the epidermis, skin appendages) to assign isolated skin fragments to certain regions of the body.

Adult↗
PubMed1984

[Death in a tetany attack].

A case of latent tetany in a 24-year-old woman is reported. She had suffered several attacks of tetany in the last 12 years, mostly triggered by external stimuli. One evening, the woman was found dead in the hall of her flat beside the telephone with the upper limbs in a tetanic convulsive attitude. The attack of tetany was triggered by a telephone conversation. The parathyroid glands were normal. Day-old purulent myocarditis could be demonstrated in the left ventricle under the light microscope. The two possible pathogenetic explanations of the causal chain leading to death are discussed. It was astonishing that a clinical symptom (tetanic convulsion) was fixed in rigor mortis.

Adult↗
PubMed1984

[Iatrogenic histopathological findings. A systematic compilation].

A series of drugs and diagnostic agents are deposited (mostly in a metabolized form) in various human organs or cause characteristic histological pictures there. These iatrogenic alterations can frequently be recognized even after a short time and can be demonstrated for varying lengths of time. They may become relevant in various respects in terms of forensic medicine: (1) as an aid to identification in unknown cadavers or cadaver parts, (2) in establishing iatrogenic damage, (3) as an evaluation of findings in sudden and unexpected death from natural causes, and (4) in problems of insurance law with regard to morphological demonstration of chronic drug abuse, especially abuse of analgesics. In a systematic review broken down according to organs, a series of these drugs or diagnostic agents are presented with the morphological alterations they caused, the methods of histological demonstration and the duration of identifiability.

Adult↗
PubMed1984

[Structure of the hair in thallium poisoning].

The alterations in the hair roots discovered by Widy in 1956 were interpreted as accumulations of pigment which form as a consequence of a catalytic action of the poison. The goal of the present investigation was to clarify the structure of these inclusions. Hair from the heads of six victims who were involved in the poisoning of Würzburg medical students in January 1983 was available as investigation material. In the investigation in transmitted light and in polarized light, the black zones typical for thallium intoxication were found filling to varying extents the root and hair shaft near the root. Their intensity corresponded to the degree of severity of the intoxication. When examined under reflected light, the inclusions were shown up with a white color. They thus showed the same optical behavior as the air-filled medullary strand of normal hairs. This indicates that gaseous constituents are involved. This hypothesis could be confirmed by further investigations. After mechanical damage to the hair (pressing under high pressure), the gaseous inclusions disappeared and with them the "thallium strip." The same effect was attained by the chemical action of various acids, embedding agents, and dye solutions. This process was especially rapid after exposure to thioglycolic acid; the escape of the gas bubbles can be directly observed here. Scanning electron microscopic investigations on transverse sections of hair revealed a loosening of the spindle-shaped elements of the fiber layer as signs of structural disturbance. The gaseous constituents in thallium hair arise as the result of a trophic disorder in keratin formation. The structural alteration due to this leads to alopecia.

Adult↗
PubMed1980

[Rupture of intestine and mesentery due to fall from height (author's transl)].

Twenty-five cases of falls from heights are reported under the aspect of lesions of the intestinal tract depending on height of fall and impact. Rupture of mesentery occurred in five cases, in only one case a rupture of intestinal wall. The results verify the thesis, asserted in a recent investigation of injuries caused by maltreatment: direct and not indirect forces lead to isolated lesions of intestinal tract.

Accidents↗
PubMed1980

[Isolated injuries of intestinal tract due to body maltreatment (author's transl)].

Three cases of fatal blunt abdominal trauma due to physical abuse are reported. Rupture of intestine and mesentery occurred after maltreatment by kick, battering, shaking, and throwing off on a mattress. The different mechanisms leading to these injuries are discussed. Small bowel lesions secondary to direct laceration are recognized to be more probable than due to indirect trauma.

Adult↗
PubMed1975

Inhibition of platelet aggregation caused by estrogen treatment in patients with carcinoma of the prostate.

Platelet aggregation is increased in patients with carcinoma of the prostate treated with estrogens. Hence, these patients have a high incidence of cardiovascular and thromboembolic diseases. Platelet aggregation has been tested with the platelet aggregation test. It was inhibited by administration of 500 mg. acetylsalicylic acid twice daily. An aggregation inhibiting effect has been found in all 38 patients. To reduce the excess hazards of cardiovascular complications of estrogens in treating carcinoma of the prostate acetylsalicylic acid is recommended as an adjunct therapy.

Aspirin↗
PubMed1975

[Inhibition of platelet aggregation under estrogen-treatment in patients with carcinoma of the prostate (author's transl)].

In patients with carcinoma of the prostate treated with estrogens platelet aggregation is increased. Patients with increased platelet aggregation have a high incidence of cardio-vascular and thrombo-embolic diseases. Platelet aggregation was measured by the platelet-aggregation test (PAT). Platelet aggregation was inhibited by administration of acetyl-salicylic acid (ASS) 2 times 500 mg daily. An aggregation inhibiting effect was found in all 38 patients. To reduce the cardio-vascular complications of estrogens in treating carcinoma of the prostate acetyl-salicylic acid as an adjunct therapy is recommended. A long-term study has been started.

Aspirin↗
PubMedDate not supplied

Massive hemorrhage causes changes in morphometric parameters of lung capillaries and concentration of leukocytes in microvasculature.

The study examines the changes in morphometric lung parameters caused by a massive acute blood loss. Three groups of rats were compared: In one group, massive hemorrhage was elicited prior to instillation of the fixative; in the first reference group, standard instillation fixation was performed, and in the second, the circulation was abruptly stopped before instillation of the fixative by contracting a snare around the atrioventricular sulcus of the heart. The two reference groups showed identical morphometric data except for the capillary erythrocyte volume density and its derived parameters, since the standard lung fixation procedure leads to a certain hemoconcentration in the lung microvasculature, as described previously. In the hemorrhage group the capillary volume was reduced to 43% of the value of the snare group. Together with a decrease in morphometric hematocrit (from 0.43 to 0.29), this led to a reduction of the erythrocyte volume to 27%. The alveolar surface area remained unchanged, the capillary surface area showed a tendency to be smaller in the hemorrhage group. As a consequence, the morphometric estimate for the pulmonary oxygen diffusing capacity DLO2 was reduced to about 40% of the controls. A surprising finding was the high leukocyte content in the capillaries after hemorrhage, suggesting that the leukocytes are retained in the capillaries even after severe blood loss.

Animals↗