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Biomedical subjects

R Viraben

Publications and source records attributed to R Viraben.

At least 73 records · Page 4Linked to original sources

[Etiology of bacterial vaginosis (non-specific vaginitis)].

56 women who were diagnosed bioclinically as having a bacterial vaginal infection were studied, as were 35 women as a control group. The study was a semi-quantitative analysis of the vaginal bacterial flora, both aerobic and anaerobic. It shows that Gardnerella vaginalis and anaerobic bacteria such as Peptococcus, Peptostreptococcus, Bacteroïdes, Veillonella and Mobiluncus were associated in a statistically significant way with bacterial vaginitis. On the other hand Lactobacilli were less frequently found (p less than 0.001) than in the control group of women. The way in which the microbial flora is changed has been observed during attacks of vaginitis and is discussed, as is the importance of making the diagnosis and of treating this syndrome.

Bacterial Infections↗

[Collagenous papules of the external ear. Micropapular hyalinosis of the external ear with transepithelial elimination. Relation to primary localized cutaneous amyloidosis].

Sanchez has recently described a new entity characterized by the presence of papules bilaterally located on the aural pinnae. The four presented cases concerned women. Clinical picture of the disease is, without any doubt, unusual but "hyalin" masses are non-specific since they are similar to amyloidosis on account of thioflavine T positivity and microfilamentous aspect in electron microscopy. We reported at the Meeting of the French Dermatological Society (Toulouse, November 10, 1981) a very similar case under the name of "Hyalinose micro-papuleuse de la conque des oreilles avec élimination trans-épidermique". In the present paper we report this personal case, and we point out some original findings: pigmentary changes, trans-epidermal elimination of the hyalinized findings material and presence of an inflammatory process.

Adult↗

[Constitutional painful callosities. Analgesic efficacy of etretinate].

We have recently evaluated eight patients with an unusual genetic dermatosis that was characterized by the development of painful callosities at pressure points of soles, with tender yellowish-brown hyperkeratosis. These lesions are very painful: walking produced pain that was severe. The patients performing manual labor, in addition, had multiple callosities on the palms. Hyperhidrosis of the soles and palms was frequently present. Skin lesions were first noted in adolescence. There was no similar family history. There was no personal nor family history of hair, nail or dental disease. A biopsy was performed in one case and showed a simple hyperkeratosis similar to these observed in callosities. Classification of our cases is difficult. They are not similar to the entity named "hereditary painful callosities" by Roth et al. Review of the literature did not show similar cases. The patients received Etretinate (1 mg/day/kg). In all 8 cases, a dramatic improvement was obtained within seven days; the pain disappeared entirely and the patients were able to walk again without any pain. Then, the per-day dose was diminished without reappearance of the pain.

Adult↗

[Dermatomyositis associated with lethal pulmonary fibrosis and cutaneous necrosis (author's transl)].

This clinical report concerns a 57 year old woman with dermatomyositis and cardiac involvement. After an apparent clinical and biological improve of the muscular and myocardic symptoms, a pulmonary involvement was reported. There was a persistent high rate of lacticodeshydrogenase serum activity. Then, cutaneous ulcerations and necrosis appeared on the extremities of limbs. Dermatomyositis associated with cutaneous necrosis and pulmonary fibrosis has a very severe prognosis.

Dermatomyositis↗

Idiopathic pigmentation of the hands. Professional exogenous ochronosis? A new entity?

A case of ochronosis-like pigmentation of the hands is described. The following criteria were fulfilled: (1) presence of blue to black spots confined to the hands: (2) pitch-black macroscopic appearance of the biopsy specimen; (3) abundance of granular material in the whole connective structures on microscopic examination of an unstained specimen just mounted on a slide; (4) numerous pigmented granules in the elastic and collagen fibers: (5) no family history, abnormal coloration of the urine, taking of drugs, or rheumatism; (6) onset in a manual worker exposed to benzenic substances. This seems to be a new entity, probably a variant of exogenous ochronosis produced by professional contacts with some agents and perhaps a professional benzenic ochronosis.

Adult↗

[Dermatosis caused by bone graft material (author's transl)].

Cases of dermatosis caused by surgical implants are not infrequently observed. They are represented by many clinical forms. The pathology slides most often reveal a more or less dense dermal infiltration associated with signs of allergic angeitis. The pathophysiology is described as an intermediate or retarded hypersensibility or continuous non-specific antigen stimulation. The diagnosis is confirmed by the cure following removal of the surgical implants since the epicutaneous tests are not always fiable. We noted two patients whose clinical profile ressembled that of hematodermie.

Adult↗

[Palisading granuloma of the penis: a variant of subcutaneous granuloma annulare].

INTRODUCTION: Subcutaneous granuloma annulare on the penis has only been reported exceptionally. OBSERVATION: A 41 year-old man presented with four small, asymptomatic nodules on the glans penis. Histological examination of a biopsy revealed a deep palisading granuloma progressing not only around the alcian-blue necrobiosis areas but also around the smooth muscle fibers. The lesion regressed spontaneously after two years of progression. DISCUSSION: Palisading granuloma of the penis appears to be a most particular clinical form of subcutaneous granuloma annulare. It is characterized by small single or multiple nodules localized on the penis. On histological examination, the granuloma is deep and concentrates around the network of smooth muscle fibers of dartoic origin.

Adult↗