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Biomedical subjects

R Vijayanagar

Publications and source records attributed to R Vijayanagar.

At least 19 recordsLinked to original sources

Closure of a patent foramen ovale and tricuspid valve replacement after heart transplantation.

Patent foramen ovale has been noted after cardiac transplantation. Rarely is surgical intervention warranted. In this communication we report a case of severe tricuspid regurgitation and paradoxical embolism secondary to a patent foramen ovale in a patient 19 months after heart transplantation. The patient underwent successful closure of the patent foramen ovale and tricuspid valve replacement.

Bioprosthesis↗

Blood pressure after cardiopulmonary bypass: which technique is accurate?

To evaluate the accuracy with which a patient's aortic blood pressure can be estimated upon separating from cardiopulmonary bypass (CPB), simultaneously recorded radial artery pressure, oscillometric brachial artery pressure, pressure in the CPB circuit, and the surgeon's estimate of blood pressure by aortic palpation were compared to directly measured aortic root pressure. After obtaining institutional approval and written informed consent, 20 patients requiring CPB for cardiac operations were studied. General anesthesia was induced and maintained with fentanyl, vecuronium, and enflurane. Blood pressure measurements were made before CPB and repeated 2, 5, and 10 minutes after discontinuation of CPB. Radial artery systolic pressure before CPB and radial artery mean pressure 10 minutes after CPB were different from the aortic root pressures (P < 0.05). Although the other radial artery pressures and the surgeon's estimate of systolic aortic pressure were statistically similar to the aortic root pressures, the range of differences was clinically significant. The oscillometric technique and CPB line were poor estimates of aortic root pressure. Of the techniques used to estimate aortic blood pressure, including radial arterial, oscillometric, aortic line of the CPB circuit, and digital palpation, the radial arterial was the best, and the aortic line from the CPB machine and palpation by the surgeon were the worst. When a clinician is unsure of the blood pressure during separation from CPB, direct measurement of central aortic blood pressure is advised.

Aged↗

Unknown extra cardiac echo-free space: diagnosis of a left ventricular pseudoaneurysm by color flow echocardiography.

At times, visualization of a ventricular pseudoaneurysm by two-dimensional echocardiography can be difficult. This case report describes the unique diagnostic potential of color flow echocardiography in the diagnosis of an unknown extra cardiac echo-free space, a left ventricular pseudoaneurysm. Using color Doppler echocardiography flow can be seen communicating between the left ventricle and the pseudoaneurysm.

Aged↗

Left ventricular aneurysm and intraventricular thrombi. Investigation and surgical correlations.

Formation of a left ventricular aneurysm and intraventricular thrombus represents one of the dreaded sequelae of coronary artery disease and acute myocardial infarction. The present emphasis is to reduce the incidence by reduction of cholesterol and fats, elimination of smoking, improved detection and control of hypertension and diabetes mellitus. Earlier diagnosis is available with stress testing and other noninvasive techniques. Cardiac catheterization allows detection of occlusive lesions. The CASS and other studies increasingly prove that percutaneous angioplasty and coronary artery bypass surgery improve life expectancy and implicitly should reduce the incidence of acute myocardial infarction. In the setting of the latter, thrombolytic agents may reduce the amount of myocardial injury. Despite these measures, formation of left ventricular aneurysms remains a common occurrence. Diagnosis and management are critical issues to the cardiac surgeon.

Cardiac Catheterization↗

Results of emergent versus elective cardiac transplantation procedures.

Twenty-six patients underwent emergent (Group I) and 34 patients elective (Group II) cardiac transplantation (C. Tx.) from June 1985 through June 1989. Age, sex, etiology, presence of diabetes, renal failure and pulmonary artery pressures were comparable for both groups (P greater than 0.5). Twenty-two patients were in New York Heart Association (NYHA) Class IV for Group I and 17 for Group II. Group I included 12 patients on inotropic agents, five on intra-aortic balloon pump (IABP) and one on IABP and cardiopulmonary bypass (CPB). Elective patients were stable at home. Location of the donor heart and mean ischemic times were comparable for both groups. Early mortality (within 30 days) included four patients for Group I and two for Group II. There were four late deaths for Group I patients and six for Group II. Four deaths were due to infection, six to rejection, two to malignancy, two neurological and one each to suicide and multisystem failure. Immunosuppression regimen was similar for both groups. The number and severity of early and late rejection episodes were similar despite blood group crossing in 11 patients for Group I (P less than .01). Incidence of infection was comparable. Favorable lifestyles were comparable, including employment of 12 patients for Group I and 16 for Group II. Cumulative survival for the entire series was 70% at two years. The study indicates that the results of emergent and elective cardiac transplantation procedures are equally gratifying, that mortality is mainly related to rejection and sepsis complications and blood group crossing does not significantly increase the number of rejection episodes.

Bacterial Infections↗

Fluctuations of the atrial cycle length and A-V delay with a universal (DDD) pacemaker.

The electronic characteristics of a new universal (DDD) pulse generator can result in significant shortening of the atrial cycle length (A-A interval) and shortening of the atrioventricular (A-V) interval beyond the programmed values. These pacemaker arrhythmias are entirely compatible with normal function and must not be interpreted as malfunctions.

Aged↗

Surgical treatment of 200 consecutive patients with left main coronary artery disease.

Two hundred consecutive patients underwent myocardial revascularization for left main coronary artery disease between January, 1975, and December, 1981. The mean age of this group was 64 +/- 8 years, and 78.5% of the patients were men. The anginal pattern was chronic stable in 6% of the patients and progressive or unstable in the remainder. Resting electrocardiograms showed prior myocardial infarction in 45.5%. Left ventricular end-diastolic pressure was elevated in 145 patients, and ejection fraction was less than 50% in 40 patients. The mean number of bypass grafts per patient was 3.2 +/- 1.4 (standard deviation). Seventeen patients underwent major concomitant cardiovascular procedures. The operative mortality was 3.5%, and the incidence of perioperative infarction was 3%. Factors associated with reduced operative survival were increased age; unstable angina, or acute myocardial infarction, or both; female sex; circumflex-dominant circulation; and major concomitant procedures. Late mortality at a mean follow-up of 33.5 months was 6%, and 91% of the surviving patients assessed their quality of life as "excellent" or "good."

Adult↗

Surgical treatment of mitral valve disease: pathologic findings and atrial dysrhythmia.

One hundred fifty patients underwent surgery for mitral valve disease between January 1974 and May 1981. There were 98 female and 52 male patients with a mean age of 57 years (+/- 18.6). One hundred forty-six patients were in New York Heart Association functional class III or IV. Pathologic diagnoses included 67% rheumatic (55 calcified), 27% degenerative and fibrotic, 3.3% prosthetic valve malfunctions, and 2.6% acute papillary muscle dysfunction. Atrial biopsy material was normal in 72% (37/51) and Aschoff's bodies were present in 2% (1/51). Preoperative cardiac rhythm was regular sinus in 40%, atrial fibrillation in 59%, and pacemaker-induced in 1%. Valve replacement was performed in 119 patients, commissurotomy in 26, and annuloplasty in five. Left atrial thrombus was removed from 21 patients. Hospital mortality was 10%. The 135 survivors have been followed up for an average of 30.4 months. Of patients who were in regular sinus rhythm preoperatively, 90.7% maintained it postoperatively, and 9.3% converted to atrial fibrillation. Of patients in atrial fibrillation preoperatively, 33.8% converted to regular sinus rhythm postoperatively and 66.2% remained in atrial fibrillation. These data indicate that rheumatic mitral valve disease is still the most common finding in patients coming to surgery, followed by degenerative and fibrotic mitral valve disease. Acute papillary muscle dysfunction is uncommon. The chance of preserving preoperative regular sinus rhythm postoperatively is excellent (90.7%), and a 33% conversion rate of preoperative atrial fibrillation to postoperative regular sinus rhythm is encouraging.

Adult↗

Experimental and clinical study of a new permanent myocardial atrial sutureless pacing lead.

A new permanent lead has been developed for atrial epicardial use. Early clinical evaluation (26 human implants) following thorough canine studies indicates that the new lead is safe, effective, and reliable. Canine thresholds and P-wave amplitudes as a function of implant time are similar to those of transvenous atrial "J" leads. Human thresholds at implant are higher than canine, but change less with time. Implant and acute repositioning were found to be easy. There have been no lead-related operations.

Animals↗

Characteristics of left ventricular thrombus resulting in perioperative embolism. A complication of coronary artery bypass grafting.

A review of perioperative complications of cardiac procedures at Tampa General Hospital revealed a distinct preoperative finding in several patients having embolism after coronary artery bypass grafting (CABG). From a total of over 10,000 cardiac catheterization procedures, four patients had ventricular wall motion abnormalities with discrete, mobile, pedunculated filling defects noted during ventriculography. Three of these patients eventually underwent CABG, and each had a postoperative embolic episode. A similar catheterization finding was noted in a fourth patient, who later had an embolic event. Thus, even in the absence of a discrete aneurysm, this observation suggests the need for an aggressive surgical approach to CABG patients with these ventricular filling defects.

Aged↗

Extra-anatomic bypass operation for aorto-iliac disease in poor risk cardio-pulmonary patients.

Three years experience with subcutaneous axillo-femoral and bifemoral bypass surgical procedures has been outlined in patients with poor cardio-pulmonary and other risk related factors. Special emphasis has been made regarding technical consideration; advantages and disadvantages have been discussed. There were 49 limbs at risk in this group of 27 patients requiring axillo-bifemoral in 22, and axillo-unifemoral in 5. Sixty-three percent of patients had associated arteriosclerotic heart disease and 48% had severe emphysema. There were 3 peri-operative deaths for 11% hospital mortality and 3 late deaths (12.5%). Six of the remaining patients for whom long term follow-up is available, acute graft thrombosis occurred in 3 patients salvaged by graft thrombectomy and 4 patients had late thrombosis resulting in 3 permanent graft failures. Two patients required above the knee amputation. Limb salvage and relief of lower extremity ischemic pains has been gratifying. During the limited follow-up period from 1-36 months (Mean 18) there is 87% patency rate for 43 grafts to 43 limbs.

Aged↗

The role of intra-aortic balloon pump in the management of patients with main left coronary artery disease.

Seventy-five patients with greater than or equal to 70% stenosis of the left main coronary artery (LMCA) were treated surgically between January 1974 and February 1980. The group consisted of 57 men and 18 women with a mean age of 62.8 years. All patients were symptomatic with angina pectoris, and 64 (85%) had unstable angina. Twenty-nine patients (38.6%) had electrocardiographic evidence (ECG) of old myocardial infarction (MI) and only six (8%) had a normal resting ECG. Preoperative exercise testing was done in 22 of the 75 patients. The stress test was positive in all patients, 17 (77%) of whom had greater than 2 mm ST depression; 90.6% (68/75) had significant right coronary artery disease. The intra-aortic balloon pump (IABP) was inserted preoperatively in only four patients (5%) and was required in two additional patients postoperatively. The IABP was inserted preoperatively in four patients because of medically refractory angina and not on the basis of coronary anatomy alone. An average of three grafts per patient were inserted. There were three (4%) postoperative myocardial infarctions and two (2.6%) deaths. During the follow-up period, which comprised 105 patient-years, there was one myocardial infarction and one death. These data indicate that successful surgical treatment of left main coronary artery disease can be achieved with low mortality and that routine preoperative insertion of IABP is unnecessary.

Aged↗