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Biomedical subjects

R Verma

Publications and source records attributed to R Verma.

106 records · Page 6Linked to original sources
PubMed1976

The action of D2O on the motility of human spermatozoa.

The effect of 25%, 50%, 75% and 100% D2O on the survival of human spermatozoa was investigated. More spermatozoa were affected and died more quickly as the concentration of D2O increased. Spermatozoa died instantly in 100% D2O.

Cell Survival↗
PubMed1976

Oral D2O administration and enzymatic changes in rat testis.

Heavy water caused marked gradual decrease in the weight of the body as well as the testes throughout the treatment interval ranging from 1 to 6 weeks. Following D2O oral administration, an overall significant fall in the activity of acid phosphatase and glucose-6-phosphatase was registered. On the other hand, the activity of lactic and succinic dehydrogenases, alkaline phosphatase and adenosine triphosphatase increases following D2O treatment. These changes in the enzyme activity are suggestive of an altered metabolism of the testes in response to D2O administration. Our data corroborate the view that biological systems do discriminate between H2 and D2.

Acid Phosphatase↗
PubMedDate not supplied

Percutaneous therapy of structural heart disease: pediatric disease.

Interventional therapy of congenital heart lesions at cardiac catheterization has greatly increased during the past decade. At the authors' institution, the frequency of such procedures among catheterizations has increased from 5% to more than 60%. The variety of lesions so treated continues to expand and equipment continues to improve. These procedures may be divided into 2 groups, namely (1) those involving balloon dilation of stenotic valves and vessel obstructions with stent placement being increasingly used in the latter and (2) those involving occlusion of lesions with (a) coils, such as aortopulmonary collaterals, patent ductus arteriosi and coronary artery fistulae and (b) umbrella devices, such as atrial and ventricular septal defects. These have replaced surgery as the initial procedure of choice in many lesions including valvar pulmonary and aortic stenoses, and postoperative aortic coarctation in young patients. In addition, use of the double-umbrella device even in noncongenital lesions appears promising.

Adolescent↗
PubMedDate not supplied

Amebic liver abscess: a therapeutic approach.

The clinical presentation of 48 patients with amebic liver abscess was no different than that reported in earlier studies. However, most patients were from countries endemic for parasitic disease. Failure to consider this diagnosis resulted in potentially avoidable surgery for six patients. Although metronidazole was successful primary therapy in 85% of 41 patients so treated, four of seven ruptured abscesses occurred in cases where metronidazole treatment failed. For assessment of factors that might predict metronidazole treatment failures, multiple parameters were analyzed. Of the factors evaluated, only timing of clinical response correlated with successful therapy. Ninety-four percent of metronidazole responders showed dramatic clinical improvement within 72 hours of initiation of therapy, whereas only 33% nonresponders had improved modestly during this time (P = .0014). Therefore, early diagnosis of amebic liver abscess in patients from endemic areas and treatment with metronidazole will result in successful therapy in 85% of cases. Surgical intervention or alternative medical therapy is indicated for those patients who do not respond after 72 hours of metronidazole therapy.

Adolescent↗
PubMedDate not supplied

Colonic wall necrosis due to tuberculosis in HIV-seropositive patient.

We report a 40-year-old man with sloughing off of the colonic due to tuberculous associated with HIV infection. He presented with lump in the abdomen, distention and vomiting suggestive of intestinal obstruction. Proximal loop ileostomy with closure of colonic perforation was performed, with good recovery. This was followed by antitubercular chemotherapy.

AIDS-Related Opportunistic Infections↗
PubMedDate not supplied

Neurofibromatosis: a diagnostic mimicker on CT in a known case of malignancy.

A known case of early carcinoma cervix was found to have mediastinal widening on chest radiograph and hypoechoic oval retroperitoneal lesions on USG abdomen. CECT chest and abdomen showed these to be non enhancing lymph node like round to oval discrete mass lesions in mediastinum, abdomen and pelvis. With no other suggestion of carcinoma spread, local or distant and uncommon incidence of extensive lymphadenopathy in a early carcinoma cervix, biopsy from one of the representative lesion was performed which revealed it to be benign neurofibroma. Differentiation of these strategically located benign nerve sheath tumors from lymphadenopathy can sometimes be challenging on CT scan and in a known case of malignancy or with history of surgery for malignant neoplasm it may cause concern for disease spread or local tumor recurrence. Associated imaging and clinical features can sometimes be helpful in reaching the correct diagnosis.

Adult↗
PubMedDate not supplied

The effect of diet and aspirin on patient outcome after myocardial infarction.

Recent studies show that diet and aspirin therapy inhibit platelet aggregation and may independently reduce complications and mortality in patients after acute myocardial infarction (AMI). To compare the effects of diet and aspirin, 140 patients, who were 4-6 wk post acute myocardial infarction, were assigned either to Group A (placebo with cardiovasoprotective diet) or Group B (aspirin [180 mg daily]) with fat-modified control diet in a single-blind controlled fashion. Of the 140 patients, 7 left the trial before it was completed. Of the remaining 133 patients, 68 in Group A and 65 in Group B were followed for one year. When the study began, the following factors were comparable for both groups: mean age, sex, risk factors, complications of myocardial infarction, electrocardiographic changes, and laboratory data. Group A received a significantly higher caloric intake (P less than 0.02) from complex carbohydrates, vegetable proteins, polyunsaturated fats, and larger amounts of dietary fibers, potassium, magnesium, and vitamin C compared with Group B, which received significantly larger amounts of saturated fats and cholesterol (P less than 0.01). The rehabilitation program, which included reduced smoking, increased exercise and drug therapy, was comparable in both groups. After one year, mean serum cholesterol (223.2 +/- 32.0 mg/dl) and triglyceride (156.2 +/- 13.5 mg/dl) levels in Group A, but not in Group B, were significantly (P less than 0.02) lower compared with mean serum cholesterol (241.2 +/- 39.5 mg/dl) and triglyceride (175.5 +/- 18.5 mg/dl) levels at the beginning of the study.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗