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Biomedical subjects

R Vanwijck

Publications and source records attributed to R Vanwijck.

At least 19 recordsLinked to original sources
PubMed1995

Expression of MAGE genes in primary and metastatic cutaneous melanoma.

Human genes MAGE-1 and MAGE-3 code for antigens that are recognized on melanoma cells by autologous cytolytic T lymphocytes. These antigens may constitute useful targets for specific anti-tumor immunization of cancer patients, since genes MAGE-1 and MAGE-3 are expressed in a number of tumors of different histological types, but are not expressed in normal adult tissues other than testis. This also applies to genes MAGE-2 and MAGE-4, which are closely related to MAGE-1 and MAGE-3. We have analyzed the expression of these 4 MAGE genes in cutaneous melanoma. Sixteen of 100 primary tumors vs. 69 (48%) of 145 metastases from individual patients expressed MAGE-1. Similar differences in the frequency of gene expression between primary and metastatic tumor samples were observed for MAGE-2, MAGE-3, and MAGE-4. MAGE expression in primary tumors was correlated with tumor thickness: there was a significantly increased frequency in the expression of MAGE-1, -2 and -3 in tumors of greater thickness. Benign and dysplastic nevi, as well as in situ melanomas, did not express any of the 4 MAGE genes.

Adult↗
PubMed1994

[Liposuction as a help for radiologists. Technical note].

Based on a series of eight cases of severe extravasations of contrast medium injected under pressure, the authors suggest the use of liposuction for the elimination of the toxic agent and of the infiltrated cellular tissue. If applied promptly, this simple and semi-conservative treatment salvages the skin and prevents the development of scar sequelae of the soft tissues.

Aged↗
PubMed1992

[Follow- up of a pleural malignant mesothelioma].

A case of malignant pleural mesothelioma is presented. The initial pleural abnormalities were radiologically rather non-specific and were wrongly interpreted anatomo-pathologically as pleural metastases. Chemotherapy however resulted in an exceptional survival of more than 10 years. CT scan showed the extensive pleural damage. The histologic, symptomatologic and radiologic features of this rare tumor are discussed.

Adenocarcinoma↗
PubMed1992

A comparative analysis of healing of surgical cleft lip corrected in utero and neonates.

We studied the healing process in surgically created cleft lips in fetal mice and compared it with that in newborn mice with cleft lips. Our purpose was to determine the time for optimal healing, defined as minimal scarring, for a repaired cleft lip. Full-thickness paramedian lip incisions were made in NMRI mice in utero, in 2- and 4-day-old neonates, and in adults (n = 10 in each experimental and control group). The healing process was studied by biochemical analysis of hyaluronic acid and hydroxyproline content in the repaired cleft tissue. We found that the production of hyaluronic acid remained stable during the healing period and was similar in all experimental groups. However, there was an unexplained but consistent depression in the hyaluronic acid content of fetal tissue 2 days after repair. Hydroxyproline was present in the fetal healing tissue, but in a low concentration, starting 4 days after surgical incision of the lip. The production of hydroxyproline in 2-day-old neonates was similar to that in the fetuses throughout the healing period (p less than 0.0005). However, the production of hydroxyproline increased in 4-day-old neonatal and adult tissues. In conclusion, we found an optimal healing period for mice with minimal collagen production in the late fetal stage, and this lasted 2 days after birth.

Aging↗
PubMed1990

Hand metastases from urothelial tumor.

Metastases to the hand are rare, particularly those of soft tissues. As a rule they arise in lung, breast, or kidney but other primary sites such as the bladder, have been described. We report a silent primary malignant tumor of the bladder, which came to light as soft tissue hand metastases.

Aged↗
PubMed1988

Congenital ring-constriction syndrome of the limbs; a report of 19 cases.

The authors report 19 cases of congenital ring-constriction syndrome of the limbs. Complications arose in eight of the pregnancies. The limb anomalies were always congenital ring-constrictions together with distal amputation. Moreover, 13 patients also had syndactyly and 15 associated anomalies were registered in 9 patients--8 of the limbs, 3 craniofacial and 4 visceral. One patient had a family history of hypospadias and cardiac malformation. Treatment usually required several operations, staged Z-plasty being the procedure of choice in surgical release of constriction bands. The acrosyndactylies were released early in life. More extensive fusions required division and skin grafting even if the webs did exist. The aetiology of the condition is still under discussion. The number of cases in the literature that cannot be explained by the exogenous theory of the congenital ring-constriction syndrome is increasing. Among them are four cases in our series.

Abnormalities, Multiple↗
PubMed1986

HL-A and carpal tunnel syndrome.

One hundred and five patients suffering from carpal tunnel syndrome were HL-A typed. No linkage could be demonstrated between HL-A phenotypes and this syndrome.

Adult↗
PubMed1974

[Immunotherapy].

Explore the source record for details and available documents.

Adult↗