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R Valle

Publications and source records attributed to R Valle.

59 records · Page 4Linked to original sources
PubMedDate not supplied

Outreach to ethnic minorities with Alzheimer's disease: the challenge to the community.

This article seeks to outline an outreach strategy to link dementia-affected ethnic minority elderly and their caregivers to community support resources and services. The strategy is based on the combined application of what has been termed culture free principles (appropriately translated, but more universally active approaches) and culture fair (culturally specific) techniques. The strategy calls for the separation of socioeconomic indicators from cultural dynamics. For example, many ethnic minority groups share poverty and attendant underclass status. Languages and customs vary considerably, particularly as related to helpseeking and helptaking behaviors both within and between the four major groups: American Indian/Native Americans, Asian Americans, Blacks, and Hispanics. Natural social network linkages are detailed as part of the overall effort.

Aged↗
PubMedDate not supplied

HLA-B27 subtypes in patients with ankylosing spondylitis (As) in Colombia.

OBJECTIVE: We investigated the distribution of HLA-B27 subtypes in patients with ankylosing spondylitis (AS) belonging to two ethnic groups of Colombia. MATERIAL AND METHODS: PCR-SSOs was used to detect the polymorphism in exons 2 and 3 of HLA-B27 in two groups of patients: 39 Mulattos and 20 Mestizos. Fifty-nine of them suffered of ankylosing spondylitis (AS), including two patients with ankylosing spondylitis plus anterior uveitis (AU). Only two out of eight HLA-B27 subtypes studied (B*2701-B*2708) were found. RESULTS: The distribution of these alleles in the whole population was: B*2705: 87.1% and B*2702: 12.8% in the Mulattos group; 80% were B*2705 and 20% B*2702 in Mestizos group. The distribution of HLA-B27 subtypes was: 84.74% of patients with AS were B*2705 and 15.26% B*2702. CONCLUSIONS: There was no significant difference in the distribution of HLA-B27 subtypes among the patients ethnic groups studied. Other authors have shown that B*2705, B*2702 and B*2704, the more frequent subtypes, are equally associated to the disease. Although population studies need to be done to analyze the distribution of subtypes between patients and controls, the low frequency of HLA-B27 within the normal population does not permit to do a representative number of controls; our results suggest that HLA-B*2705 and HLA-B*2702 are the subtypes more frequently associated with AS in patients from the two more prevalent patients ethnic groups in Colombia.

Alleles↗
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[Hypertension and arteriosclerosis].

Arterial hypertension is a major risk factor for atherosclerosis. The mechanisms involved include elevation of blood pressure, increased velocity of the sphygmic wave and increased blood flow turbulence. These hemodynamic features however do not fully explain the link between hypertension and atherosclerosis. An important role is also played by humoral factors including catecholamines, the renin-angiotensin-aldosterone system, serotonin, endothelin, platelets and endothelium-derived growth factors. Furthermore in the last few years great relevance has been attributed to hyperinsulinemia (accompanied by hypercholesterolemia and hypertriglyceridemia) that is frequently found in hypertensive subjects. Several recent reports on the antiatherogenic effect of some antihypertensive agents that could slow down the progression of atherosclerotic lesions in hypertensive subjects are promising.

Antihypertensive Agents↗