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Biomedical subjects

R Vaccaro

Publications and source records attributed to R Vaccaro.

108 records · Page 6Linked to original sources
PubMedDate not supplied

CD3+/CD30+ circulating T lymphocytes are markedly increased in older subjects with Down's syndrome (Trisomy 21).

CD3+/CD30+ circulating T lymphocytes were found to be increased in the blood of individuals with Down's syndrome (DS; trisomy 21). This finding appears to be related to age as the numbers of CD3+/CD30+ T cells were dramatically enhanced in the circulation of older DS subjects. Since CD30 antigen expression is considered to be a marker of T-helper-2 (Th-2) activation, and Th-2+ cells are associated with certain human pathologies, our data may in some way explain the enhanced susceptibility of DS patients to infections, malignant diseases and autoimmunity.

Adolescent↗
PubMedDate not supplied

[Recent findings on the phenotype and function of T-lymphocytes in the human colostrum].

Recent studies in our laboratory have demonstrated that the great majority of human colostral T cells display the phenotypic and functional characteristics of memory T lymphocytes, e.g. were able to proliferate in response to anti-CD3 and anti-CD2 monoclonal antibodies, and to a lesser extent, to the lectin mitogen phytohaemagglutinin. In addition, their production of interferon-gamma after anti-CD3 and anti-CD2 stimuli was similar to that calculated in autologous blood lymphocyte cultures. More interestingly, the proportion of T lymphocytes bearing the gamma/delta T-cell receptor was found to be significantly higher in the mammary secretion than in autologous and heterologous blood samples. Furthermore, these cells were mostly delta-TCS-1+, thereby suggesting that they are actively motile cells capable of migrating from lymphoid to extra-lymphoid body tissues. The fact that the phenotypic pattern of colostral gamma/delta T cells is similar, if not identical, to that of the intestinal intraepithelial counterpart suggests that these cells might originate in the gut-associated lymphoid system and home selectively to the mammary gland late in pregnancy and throughout lactation. However, additional studies are needed to confirm whether milk T lymphocytes are actively involved in the adoptive lactation transmission of cellular immunity to the suckling infant.

Colostrum↗
PubMedDate not supplied

[Initial experience in the treatment of bronchiolitis using heparin].

The aim of this paper was to evaluate the efficacy of treatment with heparin in children with bronchiolitis. We studied 30 children (average age 11.3 months) with bronchiolitis; 15 subjects were submitted to a supportive therapy with an adjunct of sodium heparin (50 U/Kg/24 h i.v.) for a time lasting 24-36 hours. The control group was managed with supportive therapy only. We considered the days of the disease and the persistence of symptoms since the admission as peculiar parameters between the two groups. The results appeared to be highly significant in the heparin treated group, with a mean duration of the diseases of 3.06 days compared to 5.53 days of the controls (p less than 0.001). These data are supportive for a possible utilization of the heparin in bronchiolitis but much more experiments are needed to confirm these results.

Bronchiolitis, Viral↗