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Biomedical subjects

R V Groover

Publications and source records attributed to R V Groover.

At least 37 records · Page 2Linked to original sources
PubMed1983

Cerebral palsy--trends in incidence and changes in concurrent neonatal mortality: Rochester, MN, 1950-1976.

We studied all identified cases of cerebral palsy (CP) born to residents of Rochester, MN, during a 27-year period. Incidence rates per 1,000 neonatal survivors were computed for three 9-year intervals. For children with persisting findings, the incidence rate of all syndromes declined from 2.3 to 1.6. For spastic syndromes, this trend was more marked (2.1 to 0.9). For newborns with birthweight over 2,500 g, both CP incidence and neonatal mortality rates (NMR) declined in parallel. For the low birthweight neonate, coincident with a precipitous drop in NMR, the CP incidence rate remained essentially unchanged. In the face of increasing neonatal survival, the overall incidence rate of CP declined. The decrease in the absolute risk of CP was limited to the greater than 2,500-g neonatal survivor.

Cerebral Palsy↗
PubMed1983

Clinical features of central nervous system involvement in E-rosette-positive acute lymphocytic leukemia.

Involvement of the central nervous system (CNS) is a well-recognized complication of acute lymphocytic leukemia. We studied the patterns of such relapse in 56 children with acute lymphocytic leukemia whose disease was classified as E-rosette-positive or E-rosette-negative on the basis of whether their leukemic blasts formed rosettes with sheep erythrocytes. In the E+ group, CNS relapse was more frequent, and relapse occurred at, or sooner after, diagnosis and was more frequently followed shortly thereafter by bone marrow relapse. In addition, the E+ group was more likely to present with focal neurologic syndromes with or without blasts in the cerebrospinal fluid, in contrast to the more common features of diffuse meningeal leukemia with increase in intracranial pressure. These observations suggest that the E-rosette-positive lymphoblasts are more likely to infiltrate into nerve and brain tissue rather than invade the meninges diffusely. If confirmed, these findings imply that treatment of the CNS involvement may need to be different in patients with E+ acute lymphocytic leukemia than in patients with E- acute lymphocytic leukemia.

Adolescent↗
PubMed1983

Preliminary communication--treatment of primary brain tumors recurrent after irradiation with aziridinylbenzoquinone (AZQ;NSC-182986).

Twenty-nine patients with primary brain tumors recurrent or progressive after cerebral irradiation were treated with AZQ. Twenty of the 29 patients had also failed prior chemotherapy. CT scan-documented tumor regressions were noted in 17.2% (5/29) and ranged from 15.0% (3/20) in patients with prior chemotherapy to 22.2 (2/9) in patients without prior chemotherapy. Myelosuppression was the only significant toxicity noted. AZQ is worthy of further studies in patients with primary brain tumors.

Adolescent↗
PubMed1981

Phase II studies of dianhydrogalactitol-based combination chemotherapy for recurrent brain tumors.

The drug combinations of dianhydrogalactitol and VP-16 and dianhydrogalactitol, VP-16, and triazinate were used in patients with primary brain tumors, principally astrocytoma, recurrent following cranial irradiation. Tumor regressions were noted in 40% of patients treated with the 2-drug regimen and in 33% of patients treated with the 3-drug regimens. Regression were noted in all grades of tumor. Poor performance score on the patients' part did not seem to effect regression rates. Myelosuppression was the principal toxicity encountered. Dianhydrogalactitol-based combination chemotherapy seems as active as nitrosourea therapy and presents an alternative to nitrosourea therapy.

Adolescent↗
PubMed1980

Seizures after head trauma: a population study.

A cohort of 2747 patients with head injuries was followed for 28,176 person-years to determine the magnitude and duration of the risk of posttraumatic seizures. Injuries were classified as severe (brain contusion, intracerebral or intracranial hematoma, or 24 hours of eight unconsciousness of amnesia), moderate (skull fracture or 30 minutes to 24 hours of unconsciousness or amnesia), and mild (briefer unconsciousness or amnesia). The risk of posttraumatic seizures after severe injury was 7.1% within 1 year and 11.5% in 5 years, after moderate injury the risk was 0.7 and 1.6%, and after mild injury the risk was 0.1 and 0.6%. The incidence of seizures after mild head injuries was not significantly greater than in the general population.

Adolescent↗
PubMed1980

Etiology and outcome in 42 children with acute nonbacterial meningoencephalitis.

In a prospective study of 42 cases of childhood meningoencephalitis occurring in 1974 and 1975, a diagnosis of an infectious agent was made in 30 (71%). California virus infections were most common; they were serious illnesses but had few sequelae. Benign illnesses with enteroviruses were also common. Miscellaneous and unknown agents accounted for the most seriously ill patients and for both deaths. Persistent neurologic deficits were unusual. Headaches, malaise, and changes in behavior were common but transient.

Acute Disease↗
PubMed1979

Primary cardiac myxosarcoma in a child.

This is a detailed clinical and autopsy documentation of a rare entity--primary cardiac myxosarcoma in a 29-month-old girl. The patient had sudden onset of right hemiplegia and angiographic evidence of multiple occlusions of the left middle cerebral artery. Subsequent M-mode and sector echocardiography showed a mobile, pedunculated left atrial tumor, which was excised. No other tumor mass was noted at the time of surgical exploration, and postoperatively, the patient received a course of chemotherapy (vincristine, dactinomycin, and cyclophosphamide). After a temporary improvement in her condition, the patient died following several days of rapid deterioration; this was 3 months after the onset of symptoms. Autopsy showed that death was due to brainstem herniation secondary to massive infiltration of the brain by tumor, and there were also widespread systemic metastases.

Brain↗
PubMed1977

Multicystic cerebral degeneration in neonatal herpes simplex virus encephalitis.

Typical herpetic papulovesicular skin lesions developed in an apparently normal infant at 12 days of age and were followed within 48 hours by signs and symptoms of acute encephalitis. Herpes simplex virus type 2 was cultured from the intact skin vesicles, and a fourfold increase in complement fixation titer to herpes simplex virus type 2 was found over the ensuing 24 days. The infant survived her acute illness, but was left with severe neurologic sequelae manifested as microcephaly with multicystic cerebral degeneration. The short-term and convalescent course is documented by serial, clinical, and EEG examinations, and the nature of the cerebral damage is demonstrated by computerized transaxial tomography.

Brain Diseases↗
PubMed1976

Spontaneous sleep and induced arousal. A depth-electroencephalographic study.

Although arousal effects from electric stimulation have been found in animals, reports of similar responses in humans have been uncommon. During depth electroencephalography in a 16-year-old boy for evaluation of intractable temporal lobe seizures, electric stimulation of a pair of contact leads located within the dorsal and medial portions of the thalamus but not within specific sensory nuclei produced unequivocal behavioral and electrographic arousals from spontaneous sleep. Lowvoltage stimuli were effective during non-REM and REM sleep. These findings verify the presence of a thalamic arousal system in the human.

Adolescent↗
PubMed1975

Chronic inflammatory polyradiculoneuropathy.

The diagnostic criteria, natural history, nerve conduction characteristics, pathology, laboratory features, and efficacy of corticosteroid treatment have been evaluated personally in 53 patients with chronic inflammatory polyradiculoneuropathy (CIP) who were followed up for an average of about 7.5 years. These were patients whose monophasic neurologic deficit had not crested by 6 months, patients with recurrences, and patients with a steady or stepwise progression. The typical features of CIP include absence of an associated disease, frequent history of preceding infection or receipt of foreign protein, and tendency to involve cranial, truncal, and proximal as well as distal limb structures and to have diffusely slow conduction velocity of peripheral nerves. The most marked slowing is often very proximal. The pathologic features include serous edema, mononuclear cell infiltrates (especially in perivascular areas, but without evidence of vasculitis), macrophage-induced segmental demyelination, and hypertrophic neuritis. If our patients are representative, complete recovery occurs only infrequently; about 60% of patients are able to be ambulatory and work, 25% become confined to a wheelchair or become bedridden, and approximately 10% die from their disease. Although the bulk of the pathologic changes affect spinal roots and proximal nerves, the brain and spinal cord may be involved also. Degeneration into linear rows of myelin ovoids is the predominant type of myelinated fiber degeneration of the sural nerve at the ankle.

Adolescent↗