Isolation and characterization of the hamster C-type viruses.
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Animals↗
Biomedical subjects
R V Gilden
Publications and source records attributed to R V Gilden.
In vitro carcinogenesis studies: dual effect of RNA tumor viruses and carcinogenic chemicals or DNA viruses.
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Animals↗
Wistar-Furth rat C type virus. Biologic and antigenic characterization.
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Animals↗
Intracellular localization of mammalian type C virus species-specific (gs-1) and interspecies-specific (gs-3) antigenic determinants with the indirect immunoperoxidase technique and light microscopy.
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Animals↗
Amino terminal sequences of mammalian type C RNA tumor virus group-specific antigens.
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Amino Acid Sequence↗
Variations in sarcoma and leukemia virus activity in somatic cell hybrids.
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Adenosine↗
Rat C-type virus induced in rat sarcoma cells by 5-bromodeoxyuridine.
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Animals↗
Interactions of immunoglobulins G and M in the detection of the mammalian C-type virus cross-reactive antigen.
The mammalian C-type tumor viruses share an antigenic determinant, gs-3, located on the major internal polypeptide of the virion. Detection of this determined in gel diffusion assays by antiserums prepared in rats by immunization with rat tumor homogenates carrying murine virus and serums prepared in a rabbit by immunization with purified murine gs antigen depended on antibodies present in the fractions containing immunoglobulins M and G. The immunoglobulin G fraction by itself precipitated only the homologous murine antigen. Neither fraction alone precipitated heterologous (cat, rat, or hamster) antigen (definition of the gs-3 reaction), while a mixture of the two fractions did. The gs-3 reaction was eliminated by treatment of the serums with beta-mercaptoethanol, also indicating a requirement for immunoglobulin M antibodies.
Animals↗
Adenoviruses in human cancer.
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Adenoviridae↗
C-type virus associated with gibbon lymphosarcoma.
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Animals↗
Expression of a new complement-fixing antigen reactive with murine sarcoma virus rat antiserum in rat cells transformed by polyoma virus.
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Animals↗
C-type virus released from cultured human rhabdomyosarcoma cells.
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Animals↗
Rescue of the murine sarcoma virus genome from non-producer cells by the RD-114 type C virus.
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Animals↗
Assay of C-type virus infectivity by measurement of RNA-dependent DNA polymerase activity.
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Animals↗
Protein kinase associated with RNA tumor viruses and other budding RNA viruses.
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Adenosine Triphosphate↗
A rapid direct radioimmunoassay for type C virus group-specific antigen and antibody.
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Animals↗
The nucleotides at the RNA-DNA joint formed by the DNA polymerase of Rauscher leukemia virus.
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Autoradiography↗
Group-specific antigens of RNA tumor viruses as markers for subinfectious expression of the RNA virus genome.
Antigenic markers associated with the major internal protein of RNA tumor viruses of the C-type have proven extremely useful in natural history studies of these viruses. This protein possesses species-specific antigenic determinants, and, in the case of mammalian C-type viruses, the protein possesses crossreactive determinants as well. These determinants are, thus, useful for species identification and classification of mammalian viruses. A unique distribution of antigens in embryonic tissues of several species (where tests are available) was detected, and in addition, antigen expression in tissues appears to be controlled by a dominant gene. These data have contributed greatly to the theory that RNA tumor-virus information is inherited as part of the cellular genome.
Animals↗