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Biomedical subjects

R U Lipshits

Publications and source records attributed to R U Lipshits.

At least 19 recordsLinked to original sources
PubMed1980

[Mast cell reaction outside the acute inflammation focus].

The quantitative and morphological changes of peritoneal fluid and mesenteric mast cells, the content of cellular and free histamine and serotonin were studied in the time course of acute aseptic inflammation induced by turpentine inoculated subcutaneously into the thigh of white rats. An increase in the mast cell count and activity and cellular histamine and serotonin content was found. The highest mast cell activity was observed at the peak of acute inflammation. The development of acute inflammation was characterized by both local (in the inflammatory focus) and systemic mast cell reaction which reflected participation of mast cells in general manifestations of inflammation.

Acute Disease↗
PubMed1977

[Histamine and serotonin liberation and vascular permeability in a focus of acute aseptic inflammation].

Degranulation of mast cells of albino rat peritoneal fluid and mesentery of the small intestine and the release of histamine and serotonin in acute aseptic peritonitis began the first minute after the damage and reached their maximum by the 5-th minute; by the 15-th minute the level of free amines did not differ significantly from the initial one. The dynamics of the immediate phase of increased vascular permeability corresponded to the dynamics of the free amines. The greatest increase of vascular permeability was noted on the 10th--15-th minute; it decreased considerably by the 20th minute. It was concluded that histamine and serotonin caused an increase of vascular permeability in acute aseptic peritonitis mainly within 15 minutes after the damage.

Acute Disease↗
PubMedDate not supplied

[Mast cells of the lungs in experimental hyperergic pleurisy].

Reaction of mast cells, the content of free and cell histamine and serotonin in the lung tissue at early stage of inflammation were studied on the model of hyperergic pleurisy in albino rats. Intrapleural antigen injection to sensitized rats was followed by progressive degranulation of mast cells of pleural and subpleural lung tissue with release of histamine and serotonin. The maximal increase in the content of free amines was found after 15 min. The level of free amines did not differ significantly from the initial one by the first hour. The early activation of amines synthesis and their storage recovery were observed as well as reactions of the late phase of immunological activation in the mast cells as a leukocytic tissue infiltration by subsequently polymorphonuclear leukocytes and macrophages.

Animals↗