Search PubMed⌕ Search

Biomedical subjects

R Turner

Publications and source records attributed to R Turner.

At least 271 records · Page 15Linked to original sources
PubMed1982

Shedding and survival of herpes simplex virus from 'fever blisters'.

Shedding of herpesvirus by adults with herpes labialis and survival of the virus in the environment were examined. In nine adults with virus-positive herpes labialis, herpesvirus was detected in the anterior oral pool of seven (78%) and on the hands of six (67%). Herpesviruses isolated from patients with oral lesions were found to survive for as long as two hours on skin, three hours on cloth, and four hours on plastic. These findings support earlier recommendations for the protection of neonates from adults with "fever blisters." In addition, environmental surfaces may be a source of transmission of herpesvirus to the neonate.

Adult↗
PubMed1982

Femoral head migration after single assembly total hip arthroplasty.

One of the problems of a solid head Moore type prosthesis is acetabular migration. The compound bearing single assembly (Bateman) total hip arthroplasty is supposed to decrease the incidence of this complication. A series of 160 hips reviewed to determine the validity of the single assembly total hip suggested that intrapelvic protrusion developed only in the presence of sepsis. In the present of a dysplastic acetabulum; however, superior migration was a common occurrence unless the acetabulum was significantly deepened.

Adult↗
PubMed1980

Drug and rheumatoid factor effects on the uptake of immunoglobulin G aggregates by neurtrophil monolayers.

This study examines aggregate-cell interacations in a newly applied neutrophil monolayer system, as an in vitro model of rheumatoid inflammation. Insoluble and soluble immunoglobulin G (IgG) aggregates were combined with rheumatoid factor (RF) to produce IgG-RF complexes. The presence of RF did not significantly change the uptake of the insoluble aggregates by neutrophils as measured in the monolayer system. Neutrophils exposed to these aggregates showed significantly (P less than 0.005) greater uptake than those exposed to soluble aggregates, and the presence or absence of serum did not change these results. Increasing concentrations of radiolabeled aggregates to 1.5 mg/ml and cells to 5 X 10(6) neutrophils/ml increased cell-associated radioactivity. Addition of cytochalasin B to 5 mg/ml progressively depressed cell-associated radioactivity. Gold, but not aspirin, in therapeutic concentrations seemed to suppress aggregate uptake. This system offers a method for quantitatively assaying aggregate uptake which may be an important component of the rheumatoid inflammatory process.

Aspirin↗
PubMed1979

Putrescine uptake by the cellular slime mould dictyostelium discoideum.

1. Rapid labelling occurs when myxamoebae of Dictyostelium discoideum strain AX2 are incubated with [1,4-14C]putrescine. Labelling is energy-dependent. 2. The label enters a pool from which rapid exchange with extracellular putrescine does not occur, and labelling is believed to represent uptake into the cells. 3. The concentration-dependence of putrescine uptake indicates that a number of systems are involved, at least one of which is saturable, with a Km of 9.1 micro M-putrescine. At high putrescine concentrations the overall uptake process is non-saturable. 4. Significant metabolism of putrescine and loss of intracellular putrescine to the medium only occurred when cells were incubated with millimolar concentrations of extracellular putrescine. 5. Putrescine uptake was inhibited by diamines, polyamines, bivalent metal ions and omega-aminocarboxylic acids. 6. The ability to take up putrescine at low concentrations decreased during starvation of myxamoebae. 7. The results are interpreted in terms of a model for putrescine uptake involving adsorptive pinocytosis at low concentrations and fluid-phase pinocytosis at high concentrations.

Carboxylic Acids↗
PubMed1979

Cardiopulmonary manifestations of progressive systemic sclerosis: associations with circulating immune complexes and fluorescent antinuclear antibodies.

Sixteen patients with progressive systemic sclerosis were evaluated for cardiopulmonary manifestations of their disease and for serologic immune abnormalities. Twenty-five percent of patients had abnormal echocardiograms, and 81% had a significant reduction in pulmonary function by spirometry. Circulating immune complexes (IC) were detected in 44% of patients by using a fluorescent Raji cell assay, and these patients were more likely to have an abnormal echocardiogram (P less than 0.02). Seventy-five percent of the patients had fluorescent antinuclear antibodies (FANA) and these patients were more likely to have pulmonary disease (P less than 0.01).

Antibodies, Antinuclear↗
PubMed1979

Neutrophil enzyme activities in rheumatoid inflammation.

This study analyzed the neutrophils and sera of patients with rheumatoid arthritis and of normal controls. No significant differences were found in the activities of the granular enzymes beta-glucuronidase and lysozyme or the cytoplasmic enzyme lactic dehydrogenase (LDH). Normal neutrophils were found to release significant (P less than 0.05) amounts of the granular enzymes, but not of LDH in response to immunoglobulin G aggregates. There was no difference in the percent release exhibited by rheumatoid versus control neutrophils. Studies delineating the effects of rheumatoid factor sera and normal sera on aggregate-induced enzyme release revealed a significant negative correlation between the amount of rheumatoid factor in the sera and the percent release of beta-glucuronidase and lysozyme but not of LDH. These studies thus demonstrate no abnormalities in rheumatoid neutrophil or rheumatoid serum enzyme activities or in neutrophil response to immunoglobulin G aggregates. They suggest, however, that rheumatoid factor may partially inhibit the release of lysosomal enzymes, thus suppressing this important component of the rheumatoid inflammatory process.

Arthritis, Rheumatoid↗
PubMed1979

The leukocyte adherence-inhibition assay as a diagnostic test for multiple sclerosis: study of a substance found in MS blood.

We have modified and adapted two well-accepted cancer immunology research techniques to study blood leukocyte phenomena of MS patients. The LAI test of Halliday and Miller and the 3 molar potassium chloride (3M KCl) tumor antigen extraction technique of Dean and McCoy were adapted to extract from pooled MS whole blood an MSRM. The LAI test results of 53 of 58 MS patients (91%) were considered positive, but only three of 75 control subjects (4%) were positive when tested against the MSRM. This indicates that patients with MS had a greater specific reactivity to the MSRM than did the control subjects (healthy individuals and patients with disease other than MS). The specificity and reproducibility of this reaction were tested with materials prepared from various malignant diseases. Sensitized leukocytes showed consistently higher reactivity to antigen extracts prepared from corresponding types of tumors than to extracts prepared from tumors of other histological types. Our results indicate that (1) the LAI test is able to corroborate the neurological diagnosis of MS and (2) there is a blood constituent found only in the MS patient.

Antibody Specificity↗