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Biomedical subjects

R Tur-Kaspa

Publications and source records attributed to R Tur-Kaspa.

At least 127 records · Page 7Linked to original sources
PubMed1984

Transient electrocardiographic changes during two episodes of relapsing brucellosis.

Cardiac involvement in the course of acute brucellosis is rare and, when present, is usually manifested by endocarditis. Myocarditis is very infrequent and in the few reported cases, the course of the disease was fulminant. A patient with recurrent brucellosis who presented transient electrocardiographic T wave changes during two episodes of acute illness is reported. It is suggested that the patient had minor asymptomatic myocarditis in the course of recurrent brucellosis.

Acute Disease↗
PubMed1983

Polyuria in experimental intrahepatic cholangitis induced by alpha-naphthyl-isothiocyanate.

Alpha-naphthyl-isothiocyanate (ANIT)-induced intrahepatic cholangitis was associated with significant polyuria in rats. The urine output in the experimental rats was about two and a half to four fold higher than that in the controls. The polyuria was accompanied by polydypsia and disappeared when water intake was limited and controlled. The glomerular filtration rate and renal histology remained intact. Dilution and concentration capacities were preserved and the response to exogenous anti-diuretic hormone was intact. Following water deprivation, the water and electrolyte contents of the renal medulla and papilla were similar in both experimental and control rats. The excretion of a salt-load in ANIT-treated rats was delayed. It is concluded that the polyuria in ANIT-treated rats is secondary to polydypsia. The finding of preserved dilution and concentration capacities in this experimental model contrasts to that in other experimental models of hepatobiliary disease.

1-Naphthylisothiocyanate↗
PubMed1983

Posttransfusion non-A, non-B hepatitis after cardiac surgery: a prospective study.

In a prospective study of 50 recipients of HBsAg-negative blood who had undergone cardiac surgery, 4 (8%) developed acute non-A, non-B hepatitis. The patients who developed hepatitis had received significantly more units of blood or blood products than the patients who had no hepatitis. The incubation period of the disease was 4-13 weeks, 3 patients were asymptomatic with peak alaminotransferase (ALT) levels of 320-497 U/1 and 1 patient was jaundiced with a peak ALT of 3,400 U/1. 1 of the patients had high ALT levels after 21 weeks of observation, while 3 patients recovered after 7-10 weeks. It is concluded that non-A, non-B posttransfusion hepatitis in Israel is a medical problem similar to that in the USA and that the clinical picture of the disease varies from a mild asymptomatic to a symptomatic and protracted course.

Adolescent↗
PubMed1982

Non-A, non-B hepatitis not following transfusion: a study of hospital patients in Jerusalem.

An analysis of the etiology of acute viral hepatitis in 172 hospitalized patients showed that 70.9% suffered from hepatitis A (HA), 12.2% from hepatitis B (HB), 1.7% from infectious mononucleosis and 15.1% (26 cases) from non-A, non-B hepatitis. Patients who had received blood transfusions during the 6 mo preceding the onset of the disease were not included in the present survey. The male:female ratio in the patients with non-A, non-B hepatitis was 1:88; 73% were Ashkenazic and 27% non-Ashkenazic Jews. The ethnic distribution of patients with non-A, non-B hepatitis was similar to that of patients with HA but differed from that of HB patients (only 41% Ashkenazic). Thirty-eight percent of the non-A, non-B group had had contact with jaundiced patients during the 6 mo preceding the onset of the disease, and 46% were students or soldiers. The clinical course of the disease was, on the whole, milder than that of HB and similar to that of HA. Since many cases of non-A, non-B hepatitis are anicteric, it is concluded that the disease is a significant problem in Israel.

Adult↗
PubMed1982

Serum amyloid P-component as a marker of liver disease.

The P-component of amyloid is a normal serum protein designated SAP. In view of recent in vivo experiments that suggested a possible role for the liver in the synthesis of SAP, we decided to evaluate the usefulness of its serum level as a marker of liver involvement. The study included 198 healthy adults, 154 patients with liver diseases, and 27 HBsAg carriers. Normal serum level of SAP was 66.12 micrograms/ml for males and 57.17 micrograms/ml for females. Patients with liver disease had a significantly decreased level of SAP. The mean serum level of SAP in cirrhosis was 30.15 in chronic active hepatitis--37.16 and in acute hepatitis--44.86 micrograms/ml. Asymptomatic HBsAg carriers had a normal SAP level (mean 65.48 micrograms/ml). Thirty-two patients with acute hepatitis were tested during the acute stage of the disease and after complete recovery. In all but three patients, a significant increase in SAP level, from a mean of 35.8 to 58.48 micrograms/ml, was observed. These results suggest a close correlation between serum levels of SAP and the degree of disease activity and hepatic impairment in patients with liver diseases, especially in those with acute hepatitis. Repeat determinations of SAP in patients with liver diseases could possibly help in their routine management.

Adult↗
PubMed1982

Histocompatibility antigens and cell-mediated immunity in carriers of hepatitis B virus; a study of a family.

The cause of the HBsAg carrier state is unknown, and environmental genetic and immunologic factors have been implicated. Herein, a family is described in which the carrier state was associated with the HLA-A28BW15 haplotype and with impaired cell mediated immunity. The relevance of the genetic marker in this family is uncertain. It could be associated with a genetic susceptibility to the virus or alternatively with inherited immunodeficiency. According to the first possibility the impaired immunity could be secondary to the persistent viral infection. According to the second one the acquisition of the carrier state could result from the inherited immune defect.

Carrier State↗
PubMed1981

Immunological evaluation of asymptomatic carriers of hepatitis B virus.

The immune system of 69 asymptomatic HBsAg carriers with normal liver function tests was evaluated. B cell function, as documented by serum immunoglobulin levels, number of mouse rosette-forming lymphocytes and lymphocyte reactivity to staphylococcal protein A, was intact. On the other hand, T cell function was markedly impaired. This was manifested by a significant decrease in E rosette-forming lymphocytes, an increase in stable rosette-forming cells and decreased reactivity to phytohaemagglutinin and concanavalin A. These data rule out the possibility that the immunological aberrations associated with hepatitis B infection are secondary to liver injury. The abnormal immune state either precedes the viral infection, thus predisposing to the acquisition of a carrier state or, alternatively, is a direct result of the infection.

Adult↗
PubMed1981

Study of 90 hepatitis B surface antigen carriers in Israel.

A study of 90 asymptomatic hepatitis B surface antigen (HBsAg) carriers in Jerusalem showed a predominance of males over females (4:1) and of North African Jews over Jews of European or American Origin. The predominance of males remained apparent, but was not significant, when origin was controlled. Possible sources of infection were contact with jaundiced patients (29%), dental treatment (58%) and drug addiction (8%). Fifty-one percent had hepatitis B core antibody (anti-HBc) of the IgM class, 2% had hepatitis B e-antigen (HBeAg), 94% hepatitis B e-antibody (anti-HBe) and 93% had hepatitis A antibody (anti-HAV). Fourty-two percent had donated blood at least once prior to the detection of the carrier state. Fifty-five percent of 128 asymptomatic family contacts had evidence of hepatitis B virus infection. Minor abnormalities in liver function tests were found in 22% of the carriers and splenomegaly in 11%. Of ten liver biopsies performed in these cases, one had chronic active hepatitis, five had minimal histological changes, and four were normal.

Adolescent↗
PubMed1980

Left ventricular function in liver cirrhosis: an echocardiographic study.

Left ventricular (LV) size and function were studied by echocardiography and measurement of systolic time intervals in 14 patients with liver cirrhosis. There was a small increase in LV end-diastolic dimension, and an increase in systolic ventricular performance, calculated stroke dimension and stroke and cardiac indices. Mean blood pressure was low normal. Preejection period was shortened and the preejection period/LV ejection time ratio, decreased. The data indicate that patients with liver cirrhosis have mild LV enlargment, reduced peripheral resistance and an increase in mesurements of systolic LV performance.

Adult↗
PubMed1980

Wolff-Parkinson-White syndrome: disappearance of preexcitation and appearance of complete heart block, probably due to myocardial infarction.

The appearance and gradual progression of atrioventricular (A-V) block in the presence of the Wolff-Parkinson-White (WPW) syndrome is an intriguing phenomenon. The vast majority of the reports up to date describe persistence of preexcitation in the face of partial or complete heart block. We describe a patient with severe coronary artery disease, in whom WPW disappeared suddenly, transiently at first, during coronary bypass surgery, and then permanently, probably as a result of an acute myocardial infarction, and in whom all the sinus beats during relentlessly progressive heart block were conducted through the normal A-V conduction system only.

Coronary Artery Bypass↗
PubMed1979

Liver scanning for amyloid.

Subsequent liver scans with both 99mTc-colloid and 99mTc-diphosphonate in a patient with biopsy proven liver amyloidosis are described. The colloid liver scans demonstrated the variable pattern which can be obtained at different stages of the disease, whereas, the absence of Tc-diphosphonate uptake, by the infiltrated liver, did not confirm previous suggestions about the amyloid seeking properties of this material.

Aged↗
PubMed1979

Pituitary enlargement secondary to hypothyroidism associated with sublingual thyroid gland.

Two patients with sublingual thyroid glands and hypothyroidism since childhood are described. Because of enlargement of the sella turcica both were erroneously diagnosed as having primary pituitary tumors resulting in secondary hypothyroidism. One of the patients was even treated with pituitary gland irradiation. Following substitution thyroid therapy, thyroid-stimulating hormone (TSH) levels promptly returned to normal. Ectopic thyroid glands, which are often incapable of adequate hormonogenesis, may cause secondary pituitary enlargement and lead to the suspicion of a pituitary adenoma. The correct diagnosis can easily be established by measuring serum TSH levels, which are elevated in the former condition.

Adult↗