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Biomedical subjects

R Touraine

Publications and source records attributed to R Touraine.

At least 37 records · Page 2Linked to original sources
PubMed1989

[Negativity of Borrelia burgdorferi serology in scleroderma en plaques].

The occurrence of morphea has been attributed to Borrelia, burgdorferi infection, but the relationship between localised scleroderma and borreliosis remains controverted. Antibodies directed against B. burgdorferi were looked for in 21 patients (18 female and 3 male, aged from 8 to 63 years) whose disease had been present for 6 weeks to 13 years. One patient had a single morphea, two had monomelic scleroderma and 18 had multiple localised morpheas. The search for antibodies was conducted in these 21 patients and in 200 blood donors from the Paris region by indirect immunofluorescence techniques, using the CDC method where only antibody titers of 1/256 or more are significant. Serology was lower than 1/256 in 20 cases and equal to 1/256 in one case. Among the 200 blood donors, five (2.5%) had antibody titers of 1/256 or more. None of the patients studied had been exposed to tick bite due to their occupation or place of residence. We therefore found no evidence of a link between B. burgdorferi infection and morphea in the Paris region.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1989

[Postoperative pyoderma gangrenosum and cancer of the breast. Apropos of a case].

Pyoderma gangrenosum (PG) is a extending necrotic ulceration with bluish and purplish red margins. This disease is often associated with ulcerative colitis, systemic, hematologic or rheumatic affections. However post-surgical idiopathic PG can occur. One post-mammectomy case is reported. PG can first be suspected on clinical aspect, lack of a specific etiology. PG is a diagnosis of exclusion that is made only after others possibilities are ruled out. The treatment is surgical excision and general corticotherapy.

Adult↗
PubMed1988

[Mucociliary function of 10 patients with ankylosing spondylarthritis with normal lung radiographs].

Bi-apical pulmonary fibrosis particular to ankylosing spondylitis is found in 1 to 10% of cases. The non-specific fibrosis or fibrosis of a more specific character such as iritis or the aortic disease are discussed. The fibrosis may be provoked by repeated infections which would favour an eventual hypoventilation at the apices secondary to the rigidity of the thoracic cage. To test this hypothesis we have studied muco-ciliary clearance in 10 subjects presenting with ankylosing spondylitis without any pulmonary radiological lesion and have compared these to 7 control subjects. No statistical difference was found in the clearance rate between the control subjects and the patients on the one hand (whether or not they had extra articular manifestations) and between the different areas of the lung (notably superior and inferior) in patients on the other hand. Thus this bi-apical fibrosis does not seem to explain the phenomena repeated infections at the apices which might have been favoured by any secondary deficiency in muco-ciliary clearance and hypoventilation of the apices. It seems most likely that the fibrosis has a specific origin related to the nature of the disease.

Adult↗
PubMed1988

[Mucocutaneous involvement in Behçet's disease].

The mucocutaneous manifestations of Behçet's disease consist of recurrent buccal aphthous ulcers, mucocutaneous genital aphthous ulcers and cutaneous folliculitis and pseudo-folliculitis, nodular lesions particularly affecting the limbs, which have been recognised more recently. In the absence of any laboratory criteria, mucocutaneous lesions represent a fundamental diagnostic element, as they are almost constant, either right from the onset of the disease or during the course of the disease. Non-specific cutaneous hypersensitivity may also be an important element guiding the diagnosis. These manifestations are due to vasculitis, the fundamental anatomical lesion of Behçet's disease.

Adult↗
PubMed1988

[Agenesis of the pericardium: clinical, echocardiographic and MRI aspects].

A case of agenesis of the pericardium is reported. The condition is are; a search in the literature has yielded 364 cases. It always results from an abnormal embryonic development. The agenesis is more common on the left side (70%) than on the right side (4%) or the inferior side (17%). It is more often partial than total (9%) and may be associated with other malformations, particularly malformations of the heart. The diagnosis rests on radiography of the chest and, mainly, echocardiography. CT, MRI or surgical exploration (if needed for other reasons) confirm the anatomical defect. In patients with partial pericardial agenesis the risk of cardiac entrapment makes surgery mandatory.

Adult↗