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Biomedical subjects

R Torigoe

Publications and source records attributed to R Torigoe.

At least 55 records · Page 3Linked to original sources
PubMed1991

[Effects of hypothermal and circulatory arrest on the auditory brainstem response during operation in children].

Twenty-two children were monitored by the auditory brainstem response (ABR) during the open chest and/or open heart surgery for cardiac anomalies under the extracorporeal circulation (ECC) with moderate to deep hypothermia. These patients were divided into two groups, namely, the ECC only group (group A: 9 cases) and the total circulatory arrest (TCA) group (group B: 13 cases). The mean age of group A was 36 months and group B was 6.1 months. In group A, moderate hypothermia was conducted with the rectal temperature ranging from 25 degrees C to 30 degrees C, and in group B profound hypothermia was conducted lowering the temperature to 18 degrees C. The ABR recorded at the following points, namely; before inducing anesthesia, before lowering the body temperatures, during the cooling process, at the time of TCA, and during the rewarming process. Accompanying the decrease in body temperature the peak latency of waves I, III and V were markedly prolonged. When the rectal temperature fell to 23 degrees C, the peak latency of each wave was prolonged to about 150% of their precooling values at 36 degrees C. When it fell to 22 degrees C, the ABR disappeared entirely in 16 of 22 cases, and in remaining 6 cases, only I wave was detected. During rewarming, in both the A and B groups, at 24 degrees C, the wave of ABR started to reappear beginning with I waves, and on reaching 26 degrees C, I, III and V waves from became detectable. The peak latency of all waves at rectal temperature of 33 degrees C recovered to almost the same values as these at 36 degrees C.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1991

[Skin penetration of antimicrobial agents in rats].

Skin penetration of various antimicrobial agents was studied in rats. Skin concentration/serum concentration ratios were classified into three groups, i.e. group I with ratio greater than or equal to 0.7, group II with the ratio 0.7-0.4 and group III with the ratio less than or equal to 0.4. The drugs of group I were OFLX, CPFX, LFLX, FLRX, SPFX, AMK, EM, RXM, CAM, CLDM. The drugs of group II were ABPC, CVA/AMPC, CVA/TIPC, CEX, CED, CXD, CTM-HE, CXM-AX, CPZ, CBPZ, TFLX, ASTM, MINO. The drugs of group III were AMPC, CCL, CDX, CPDX-PR, CFTM-PI, CTZ, CEC, CEZ, CTM, CMZ, CZON, MCR, IPM/CS. Factors which may influence the skin penetration were discussed, but no definite conclusion has not been obtained.

Animals↗
PubMed1990

Behavioral changes in 6-hydroxydopamine-treated rotation rats after delivery of various neuromodifying agents by means of a stereotactically implanted pellet to the brain.

Small pellets loaded with apomorphine, thyrotropin-releasing hormone, and bromocriptine were implanted into the right striatum of 6-hydroxydopamine-treated rotation rats, and the efficacy of this drug delivery system was examined. Pellets containing neuromodifying agents, when implanted into the brain, may be just as effective as brain grafting in delivering various chemical agents to the brain. This method is much safer and simpler than brain grafting, since it bypasses many of the complicated problems associated with brain grafting. Application of this method to an animal experimental model for brain grafting and possibly in the treatment of parkinsonism should be considered along with brain grafting.

Animals↗
PubMed1990

Adrenal medullary graft to brain in 6-hydroxydopamine-lesioned rotation rats. Comparison of two different graft sites (striatum versus lateral ventricle) by behavioral observation and fluorescence histochemistry.

Using 6-hydroxydopamine-lesioned rotation rats as a model of Parkinson's disease, an investigation was made of the optimal site for transplantation of adrenal medulla. One site was selected in the striatum (striatum group) and one in the lateral ventricle close to the striatum (lateral ventricle group). 6 weeks after grafting, the rotational behavior in the striatum and ventricle group was reduced by 43% (p less than 0.01) and 35% (p less than 0.01), respectively, as compared to the control group. 12 weeks after grafting, these figures were 30% (p less than 0.05) and 17% (n.s.). The striatum was slightly superior to the lateral ventricle as the site for transplantation.

Adrenal Medulla↗
PubMed1990

[Clinical analysis of shunted hydrocephalic neonates and sucklings--observation on obstruction and infection of shunting system].

Although ventriculoperitoneal (V-P) shunt is common as the surgical procedure for hydrocephalus, mechanical malfunction and infection are the most significant problems. Despite the current use of variety of mechanical shunting systems, shunt malfunction remains a major problem in pediatric neurosurgical practice. Pathological lesions associated with malfunctioning shunts have been studied only infrequently. From April 1980 to December 1987, we experienced 96 cases of V-P shunt in neonates and suckling. The therapeutic results of shunting and causes of initial shunt revision in those cases with nontumoral hydrocephalus were studied. Of 96 cases, which included 55 cases of congenital and 41 cases of acquired hydrocephalus, in which a V-P shunt had been performed, those cases with no history of shunt revision or with only elective shunt revision during the 5-year follow-up period were classified as successful shunt. The 56 of 96 cases (58.3% successful shunts included 15 of 24 patients with myelomeningocele, 7 of 10 with encephalocele, 12 of 21 with various types of cerebral anomaly, 12 of 22 with posthemorrhagic hydrocephalus and 10 with postmeningitic hydrocephalus. There were 12 successful shunts performed in 27 premature and 44 in 69 mature infants. The 40 patients (41.7% with non-elective shunt revision included 5 with breakdown of the sutured scalp with cerebrospinal fluid leakage, 20 with obstruction of the shunt system (14 ventricular side, 6 abdominal side, and 15 with infection. During the 5-year follow-up period 11 died and 85 survived 88.5%), of whom 43 (44.8%) showed normal intellectual development and 42 (43.7%) showed developmental disability.

Cerebrospinal Fluid Shunts↗
PubMed1990

[Combination effects of fosfomycin and other oral antimicrobial agents against methicillin-resistant Staphylococcus aureus].

Combination effects of fosfomycin (FOM) and other oral antimicrobial agents were studied against methicillin-resistant Staphylococcus aureus (MRSA) (methicillin: minimal inhibitory concentration (MIC) greater than or equal to 12.5 micrograms/ml) isolated from skin and skin structure infections. The fractional inhibitory concentration (FIC) index equal to or less than 0.5 was seen in 63.0% of 27 MRSA strains for FOM and minocycline combination, in 44.4% for FOM and cefatrizine, in 44.4% for FOM and cefaclor, in 40.7% for FOM and cefalexin, in 37.0% for FOM and doxycycline, in 29.6% for FOM and erythromycin, in 22.2% for FOM and rokitamycin, in 18.5% for FOM and ofloxacin, in 14.8% for FOM and sultamicillin, in 11.1% for FOM and clavulanic acid/amoxicillin. The combination effects of FOM and minocyclin, or FOM and cephalosporins were higher than other combinations with FOM. Combination of FOM with other antibiotics could be a useful way to treat MRSA skin and skin structure infections.

Administration, Oral↗
PubMed1990

[Clinical analysis of shunted hydrocephalic neonates and sucklings. Observation of postshunt complication due to overdrainage from intraventricular CSF].

During the past 3 decades hydrocephalus has been treated effectively with valve-regulated shunts and it would appear at present that this means of treatment will continue despite the fact that it probably has a higher complications rate than any other neurosurgical operation. The complications are generally categolized as those due to obstruction, those caused by infection, and those related to overdrainage. It appears, however, that the complications due to overdrainage such as the slit ventricle syndrome, the isolated unilateral lateral ventricle, and the isolated fourth ventricle and are poorly defined and understood and, therefore, the treatment has been subject of confusing literature. In this paper, the characteristics of neonatal and infantile hydrocephalus were discussed in an analysis of postoperative complications of cerebro-spinal fluid shunt procedures which focuses on the overdrainage by the shunt system. Ninety six cases of hydrocephalus which included 55 congenital and 41 acquired, were treated during a period of 7 years and 9 months. Patients with congenital hydrocephalus included 24 with myelomeningocele, 10 with encephalocele, and 21 with aqueductal stenosis associated with various cerebral anomalies. Patients with acquired hydrocephalus included 22 with posthemorrhagic and 19 with postmeningitic. There were 29 cases (30.2%) in which various complications due to overdrainage developed. In 12 of these additional conservative treatment and/or additional surgical therapies were necessary. Patients with complications included 19 (19.8%) with the slit ventricle, 6 with the unilateral isolated lateral ventricle, and 4 with the isolated fourth ventricle.(ABSTRACT TRUNCATED AT 250 WORDS)

Cerebral Ventricles↗
PubMed1990

[Assessment of cerebral infarction by MRI--particularly fogging effect].

Fogging effect in cerebral infarction was studied by MRI in a 51-year-old male patient. Initial symptoms consisted of mild disturbance of consciousness and left hemiparesis. MRI examination was performed 2, 13 and 22 days after onset and the results were compared with CT findings during the same period. CT on day 2 revealed a wide of infarction in the region of the middle cerebral artery including the basal ganglia. The presence of a fogging effect was seen by CT on day 12 and MRI revealed a high signal intensity in the region of the basal ganglia in T 1 image, a high signal intensity in the peripheral region and a low signal intensity in the center in T 2 image. It was possible to define the lesion as the ordinary infarcted lesion by the subsequent CT and MRI. MRI indicated the infarct lesion was to be a high signal intensity in T1 image and a high signal intensity in the periphery and a low signal intensity in the center in T 2 image. It was concluded that these findings indicated hemorrhage, strongly suggesting that the cause of the fogging effect was hemorrhagic infarction.

Cerebral Hemorrhage↗
PubMed1990

[Behavioral and histochemical observation in rotational rat with adrenal medulla transplantation].

It is widely known that rotation rat is prepared by destroying substantia nigra pars compacta in the rat. Adrenal medulla was transplanted to the rat. The transplantation was judged to be effective in the rat to which adrenal medullary cell was transplanted as the number of rotation decreased evidently in the rat with transplanted adrenal medulla even in the change in the rotating motion after actual transplantation. On the other hand, many transplanted cells transformed into nerve cell which was considered to have produced dopamine were observed in the rat in which transplantation was judged as effective in the histochemical assessment made of the group undergone transplantation of the adrenal medulla. However, in the rat in which no decrease in the number of rotation was observed, only the transplanted cells which were presumed to be the primary adrenal medullary cells were existent. The fact suggests that take of dopamine-producing cells is necessary to see decrease in rotating motion which is found to be the judging criterion for clinical effect.

Adrenal Medulla↗
PubMed1989

[Hemiplegia cruciata caused by a stab wound of the spinal cord. Case report].

A 56-year-old female sustained a neck laceration by a piece of glass, which broke when she fell backward. She immediately became quadriplegic and was transported to a local hospital, then deteriorated and was referred to the authors' hospital. Neurological examination revealed quadriplegia that was particularly pronounced in the right arm and left leg. Pain sensation was decreased in the right upper and lower extremities below the C3 level. Cervical spine films showed glass fragments in the gap between the occipital bone and the C1 arch. Computed tomography dramatically demonstrated glass fragments that had become fixed in the spinal cord at the spinomedullary transition. A suboccipital craniectomy and C1 laminectomy allowed visualization of the dural laceration. Opening of the dura exposed a glass fragment penetrating the upper cervical spine just caudal to the left tonsil. It was successfully removed with a hemostat clamp. Postoperatively, the patient was soon able to walk without assistance. To the authors' knowledge, upper cervical spinal cord injury caused by glass has previously been reported only twice, although broken glass is a common cause of wounds. Also, this patient exhibited signs of "hemiplegia cruciata," which is thought to be due to damage to the pyramidal decussation.

Female↗
PubMed1988

[Recurrent postictal pulmonary edema--a case report].

A 32-year-old woman was examined in the Department of Internal Medicine at Saiseikai Fukuoka General Hospital after a grand mal seizure on December 29, 1985. She had a history of eclampsia 5 years before but had had no evidence of convulsive seizure. Chest examination revealed rales over the bilateral chest. The cardiac examination revealed no abnormalities. Laboratory data on admission included a total white blood cell count of 13000/mm3. The electrocardiogram also failed to reveal any abnormalities. Analysis of arterial blood with the patient breathing room air revealed a PaO2 of 51.2 mmHg, PaCO2 of 33.1 mmHg and a pH of 7.426. The chest film showed diffuse bilateral nodular-appearing alveolar infiltrate and a normal cardiac size. Cardiac function test using Swan-Ganz catheter was performed after 10 hours of onset. However, no abnormalities in pulmonary arterial pressure (PAP) and pulmonary capillary wedge pressure (PCWP) were noted. She was treated with Latamoxef and supplementally inspired oxygen. A repeat chest roentgenogram taken 7.5 hours after admission showed marked improvement. She was discharged without any residual symptoms and continued as an outpatient under the administration of sodium valproate. However, the drug was discontinued because of the presence of seizure was under suspicion. On August 24, 1986, she was readmitted for pulmonary edema after another grand mal seizure. The clinical course was uneventful and was almost the same as the previous episode. She was treated with oxygen only, via nasal catheter.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1987

[Chronic calcified subdural hematoma--report of a case].

An 82-year-old woman was admitted to the Department of Neurosurgery, Saiseikai Fukuoka General Hospital with complaints of persistent headache and left hemiparesis. Neurological examination on admission revealed mild left hemiparesis with hyperreflexia. However, no choked disc nor pathological reflexes were noted. Roentgenograms of the skull showed thickening of the bone in the right temporoparietal region with intracranial calcification. CT showed a large right frontoparietal mixed dense space-occupying lesion bordered by a high dense calcified rim. The right lateral ventricle was compressed while the left exhibited a deviation to the left. Furthermore, thickening of the right frontal and parietal bone around the margin of mass was noted. The patient was operated upon under the diagnosis of calcified chronic subdural hematoma. A large osteoplastic flap was turned down on the right front parietal area and hypertrophy of the skull, especially around the hematoma, was noticed. Over the dura just beneath the hypertrophic lesion of the calvaria, a soft, reddish granulation tissue was noted. The dura was stripped easily from the outer membrane. The capsule was opened and the content was found to be of compact consistency, screeching when cut, and it appeared to be filled with large clots, not all homogeneously organized and made out of a substance composed of reddish-yellow material. The inner membrane was removed except for the frontal lesion where remarkable adhesion to the arachnoid membrane was noted. The postoperative course was uneventful. At the time of the patient's dismissal, her symptoms had completely disappeared. Histologically, the granulation tissue to be the bone marrow consisted of three hematopoietic cells.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1987

[A case of superior sagittal thrombosis secondary to hyperlipidemia].

A 42-year-old man was admitted to the Saiseikai Fukuoka General Hospital on March 22, 1985 with complaints of nausea, vomiting and headache which had continued for twelve days. On physical examinations, multiple subcutaneous nodules were noted in the chest, abdomen and extremities with dilated veins in the chest wall. Furthermore, the discoloration of the skin attributable to the venous occlusion was noted in the left foot. Neurological examinations failed to reveal any abnormalities except for moderate choked disc in bilateral ocular fundi. Spinal puncture revealed CSF pressure as high as 350 mmH2O with slight increase in cell numbers. CT demonstrated small intracerebral hematomas bilaterally in occipital lobes with evidence of "empty delta" sign in the superior sagittal sinus. On angiographical findings, the superior sagittal sinus was not demonstrated in venous phase and the blood was drained mainly through the paravertebral plexus and the pterygoid plexus without any abnormalities in arterial and capillary phases. Serological examination revealed a hypercoagulability and hyperlipidemia especially in LDL (Low Density Lipoprotein) and VLDL (Very Low Density Lipoprotein). On etiological considerations, all of these abnormalities seemed to be derived from the hyperlipidemia. Furthermore, multiple symmetrical lipomatosis was defined as a "lipoprotein storage disease" in which laboratory examinations revealed hyperlipidemia especially in LDL and in some subfraction of HDL. Although not a typical case, there must be some possibilities that the lipomatosis of this case is secondary to disorder of lipid metabolisms. In conclusion, all of various pathological conditions observed in this case were considered to be due to the disorder of lipid metabolism.

Adult↗
PubMed1987

[A case of bilateral absence of internal carotid with cerebral aneurysm].

A 52-year-old woman was referred to the Department of Neurosurgery, Saiseikai Fukuoka General Hospital because of the abnormal findings on CT from a private hospital. She had previously had two attacks of severe headache. In May 1985, she noted severe headache with vomiting and was transported to a nearby hospital. She was hospitalized there until CT was performed. On admission, she was clear in consciousness and complained of headache of moderate degree. Neurological examination was normal except for mild nuchal rigidity. A standard series of roentgenograms of the skull revealed a round calcified area in the supraclinoidal region. CT revealed a calcified lesion which must be a vessel in the chiasma cistern just adjacent to the basilar artery which was relatively larger than normal. Furthermore, no carotid canal was visible in the bilateral petrous bone by means of bony algorythum. Selective internal carotid angiographies were attempted. There was no evidence of an internal carotid artery on either sides. Furthermore,the ophthalmic arteries were fed via external carotid systems. A vertebral angiography demonstrated bilateral hypertrophy of the vertebral artery with an aneurysmal shadow in the left P1 of the posterior cerebral artery. The supratentorial circulation was maintained via the right posterior communicating artery in the right middle cerebral artery and the bilateral anterior cerebral arteries. On the other hand, the circulation of the left middle cerebral artery was maintained by the retrograde filling from the right anterior and posterior cerebral arteries. Operation was performed by left sylvian approach followed by subtemporal approach.(ABSTRACT TRUNCATED AT 250 WORDS)

Carotid Artery, Internal↗
PubMed1987

[A case of pycnodysostosis--observation of the skull by CT scan].

A 13-year-old boy was presented to the Department of Neurosurgery, Saiseikai Fukuoka General Hospital for further examinations concerning abnormal findings in the skull radiogram taken when he struck his head. His physical features showed some characteristics the same as those of pycnodysostosis as follows--proportionate dwarfism, prominent forehead, short spoon-shaped fingers, bilateral exophthalmos. A skull radiogram revealed widely open cranial sutures with no healing of the fracture and craniotomy which was performed for an acute epidural hematoma 6 years ago. Furthermore, the mandible was hypoplastic with a virtual loss of mandibular angle. CT of the soft tissues showed somewhat dilated cortical sulci and ventricles without any structural abnormalities in the brain. CT of bone algorithm revealed specific characteristics of this disease. The paranasal sinuses were quite hypoplastic. Especially in the maxillary sinuses, frontal sinuses and mastoid air cells, none of developments of sinuses were noted, even though the middle and internal ear seemed to be normal. Moreover, the ethmoid and sphenoid sinuses were noted, although their developments were poor. The appearance of skull base was normal, including the inlets and outlets of cranial nerves or vessels and synchondroses. However, the density of the skull base, especially in the diploe, was higher than normal in Hansfield number. Furthermore, detailed measurements of skull base demonstrated that the skull base itself was also dwarfism. Pycnodysostosis is a generalized skeletal disease whose cardinal features are moderate generalized osteosclerosis and dwarfism. However, the detailed observation on the cranium by CT has not been reported. In our study, the development of sinuses in bones with intramembranous ossification are worse than that with endochondral ossification.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗