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Biomedical subjects

R Thun

Publications and source records attributed to R Thun.

At least 55 records · Page 3Linked to original sources
PubMed1990

[The uterine motility of cattle during late pregnancy, labor and puerperium. I. Spontaneous motility].

In the present study spontaneous uterine motility was recorded in 4 cows during late pregnancy, parturition and the puerperium using pressure microsensors and electrodes which were surgically implanted into the myometrium of the pregnant horn 3 to 4 weeks before parturition. Hysterograms were evaluated by means of pressure amplitude, frequency, duration, interval of uterine contractions and also by electromyography. During the last 2-3 weeks of pregnancy only single weak uterine contractions of different intensity were seen. About 18-20 hours a.p. frequency and amplitude of mainly tubocervical directed waves continuously increased. When the fetus entered the birth canal and especially during expulsion of the calf extremely strong irregular contractions occurred, which became very regular during the first hours p. p. After the placenta has been released 3-8 hours p. p., spontaneous uterine motility drastically decreased until the second postpartal week, when it started to increase again.

Animals↗
PubMed1989

Carprofen in veterinary medicine. II. Inhibitory effect on the release of PGF2 alpha in the early postpartum cow.

Carprofen, a non-steroidal anti-inflammatory drug (NSAID) known to inhibit prostaglandin synthesis, was given intravenously in five cows at a daily dose of 0.7 mg/kg for five days beginning on day 1 postpartum. Blood samples were collected at various times over a period of six days following the first injection. At this dose, carprofen reached highest plasma values of about 45 micrograms/ml after the fifth injection and was well tolerated by all the cows. During the whole experimental period, mean plasma levels of 15-keto-13, 14-dihydro-prostaglandin F2 alpha, the primary metabolite of PGF2 alpha, were significantly (p less than 0.05) lower in treated than in control animals (28-47% vs 64-101% of pretreatment concentrations). The suppressive effect of carprofen on PGF2 alpha-production occurred immediately after its application and was maximal 3-6 h post injection on the first and on the fifth experimental day (60-80% and 40-85%, respectively). We conclude from our results that carprofen in a single dose of 0.7 mg/kg b.w. effectively suppresses PGF2 alpha-release in the postpartum cow. Whether this effect is beneficial in the treatment of uterine inflammatory processes remains to be determined.

Animals↗
PubMed1989

Carprofen in veterinary medicine. I. Plasma disposition, milk excretion and tolerance in milk-producing cows.

Carprofen, a non-steroidal anti-inflammatory drug (NSAID), was injected intravenously in six cows after calving, either as a single or a daily dose of 0.7 mg/kg for five days. Carprofen was well tolerated by the cows at this dose rate, the milk production and biochemical variables remaining within the normal ranges. The plasma elimination half-life of carprofen ranged from 44.5 to 64.6 h after repeated daily injections. These values are longer than those reported for other NSAIDs used in veterinary medicine, e.g. flunixin and phenylbutazone. The volume of distribution and the clearance values calculated after a single intravenous injection amounted to 0.09 l/kg and 9.0 ml/min. The concentration of carprofen in milk collected twice daily (morning and evening) was, in general, below the sensitivity limit of the analytical method (25 ng/ml) up to five days after the last carprofen injection; the concentration of carprofen reached about 30 ng/ml in only a few milk samples collected after the fourth or fifth injection. This indicates that carprofen is poorly excreted in the milk.

Animals↗