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Biomedical subjects

R Templin

Publications and source records attributed to R Templin.

At least 55 records · Page 3Linked to original sources
PubMed1978

[Possibilities and limits of kidney transplantation].

Chronic haemodialysis and renal transplantation are mutually supplementing methods for the treatment of patients with terminal renal lesion. The two methods have proved their worth in clinical practice. The expectance of life of patients with chronic renal insufficiency could essentially be improved during the last years. In last consequence the successes of the transplantation of kidneys depend on the solution of immunobiological problems, which are not yet cleared up nowadays. 1. In the determination of genotypical determinants possibly not all are known or recognizable. 2. The at present clinically usable examination methods do not yet allow to recognize rejections so early that by an aimed immunosuppressive treatment irreversible damages on the graft may be prevented. After a transplantation of kidneys of relatives a long survival time of transplanted patients is better than after a transplantation of kidneys taken from dead bodies. The rejection is still the main factor of the failure of the graft, the sepsis is the most frequent cause of death. It is neccessary, to develop less toxical remedies for the adaptation of the graft. Nevertheless, thousands of optimally transplanted patients prove the usefulness of the allogenic transplantation of the kidney.

Female↗
PubMed1978

[Enzymatic and morphologic studies on long-term perfused dog kidneys].

21 canine and 12 human kidneys were submitted to long-term perfusion for 24 hours. During that time LDH-activity, histologic, enzyme-histochemic, and ultrastructural examinations were carried out. The findings proved that kidneys with lesser damage from ischemia showed lower activities during the first 4 to 6 hours than kidneys which were more injured before. The latter showed the same ultrastructural alterations as kidneys after perfusion for 24 hours, which suggests an irreversible partial damage of the organ.

Albumins↗
PubMed1978

[Immunologic course of kidney transplants studied by means of cellular and humoral immunity tests].

In 10 human-allo-transplanted persons and evaluation of the postoperative course was done with the help of specific and unspecific, cellular and humoral immune tests which were compared with clinical parameters. While the E-rosette-test did not show any correlation to the typical courses in the immunoglobulins postoperatively after a clear decrease at the time of the clinically diagnosed first set reaction an increase above all of the IgM could be observed. Unspecific tests, such as CRP and FSP may, concerning the rejection diagnostics, confirm the suspicion in as far as other factors, such as infection of the urinary tract were excluded. By choice of a suitable relation system the evidence of the immunoglobulins could possibly be proved, whereas for the cellular demonstration methods the E-rosette test does not seem to be recommendable in the performed way.

Adolescent↗
PubMed1978

[Perfusion technic during clinical intra- and extracorporeal tumor removal from a solitary kidney].

On the basis of own experiences in operations of tumour-carrying kidneys two perfusion techniques for the intra- or extracorporal renal surgery are exolained and weighed one to another. In the in-situ-perfusion the pulsatile mechanical perfusion with supervisable flow, perfusate pressure and under direct measuring of temperature on organs has proved. The disadvantage of the in-situ-perfusion in contrast to the extra-corporal surgery consists in the impossibility of the local after irradiation.

Humans↗
PubMed1978

[Diagnostic value of determining urinary fibrin split products in glomerulonephritis, pyelonephritis and graft rejection].

On 112 patients with bioptically ascertained chronic proliferative glomerulonephritis, 94 with pyelonephritis and 23 patients with kidney transplantation altogether 1,050 times the fibrin fission products in the urine were estimated by the passive haemagglutination after Merskey. It was the aim of the investigation to test the diagnostic evidence described in literature concerning the floridity diagnostics in glomerulonephritis and the recognition of rejection in kidney transplantation as to its reproducibility. In comparison to the latent glomerulonephritis (0.3 microgram/ml) the florid glomerulonephritis (12.3 microgram/ml) as well as the acute pyelonephritis (9.2 microgram/ml) in comparison to the chronic pyelonephritis (1.3 microgram/ml) has significantly higher values. On account of the numerous "falsely positive" and "falsely negative" values in contrast to the data of other authors an activity diagnostics is not possible. Only in the glomerulonephritis with nephrotic syndrome a prognostic use is to be expected: Patients with steroid-sensitive nephrotic syndrome do not secrete any fibrin fission products in the urine and patients with steroid-resistant nephrotic syndrome secrete them in a large number. We could confirm that an increase of the fibrin fission products in the urine after kidney transplantation refers to an acute rejection crisis. Since 10 of 27 rejections were fibrin fission product-negative, in the lacking fibrin fission products in the urine a rejection is not be excluded, by which the diagnostic value is restricted.

Fibrin Fibrinogen Degradation Products↗
PubMed1978

Urinary fibrin degradation products--a three year comparative study.

Urinary fibrin degradation products (FDP) were determined by Merskey's passive haemagglutination test in 115 patients with biopsy proven chronic proliferative glomerulonephritis (GN), 94 with urinary tract infection (UTI), and 23 transplanted patients. The active GN values (12.3 microgram/ml) are significantly higher than those for latent GN (0.3 microgram/ml). Those for acute UTI (9.2 microgram/ml) are significantly higher than for chronic UTI (1.3 microgram/ml). In contrast to the reports published by others, the numerous 'false positive' and 'false negative' values make diagnosis of the activity unreliable. Some prognostic value can be expected in GN with the nephrotic syndrome (NS): patients with steroid-sensitive NS excrete no FDP and patients with steroid-resistant NS excrete larger quantities of FDP. We have confirmed that a rise in FDP level following kidney transplantation is indicative of an acute rejection crisis. However, since 10 of 27 rejections were FDP negative, the absence of FDP in the urine does not preclude rejection, so that the diagnostic value is restricted.

False Negative Reactions↗
PubMed1978

[Punch and suction biopsy in the diagnosis of prostatic neoplasms].

133 prostate punch biopsies were examined in histologic way and 90 aspiration biopsies in cytologic way. The histologic and cytologic results of the altogether 116 patients are discussed in connection with the differently tentative findings of rectal palpation. Prostate punch and aspiration biopsies can be used as completion methods in cancer prophylaxis examination. The all-metal needle after Deutschmann (Zittau/GDR) repeatedly to be used for punch biopsy has proved its worth.

Adenocarcinoma↗