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R Tauber

Publications and source records attributed to R Tauber.

At least 109 records · Page 6Linked to original sources
PubMed1982

Urinary cholesterol in cancer screening.

Cholesterol determinations in morning urine samples were taken in 235 selected patients with a positive test for microscopic hematuria. Values ranged from 0.2 to 76.0 mg (median 5.5) in 23 patients with urologic malignancies and from 0.1 to 33.4 mg (median 1.1) in 38 patients with various benign diseases of the kidney or urogenital tract. In the 28 patients with urinary tract infections and 146 subjects without evidence of disorders of the kidney and the urogenital system, urinary cholesterol excretion was usually normal (0.1 to 1.9 mg; median 0.35). Using 1.0 mg urinary cholesterol per morning urine as a cutoff point, sensitivity for urologic carcinomas is about 80 per cent with a comparable high specificity of 90 per cent. Therefore, subsequent measurements of urinary cholesterol in populations with microscopic hematuria could define two groups, one with high prevalence and one with low prevalence of urologic malignancies. The less complicated colorimetric instead of gas-liquid chromatographic determination of urinary cholesterol can be recommended as a screening test for urologic carcinomas in populations with microscopic hematuria.

Aged↗
PubMed1982

[Bone sarcoma after radiotherapy. Apropos of 5 cases].

The authors describe 5 cases of bone sarcoma appearing between 9 and 29 years after radiation therapy. One patient was still surviving 21 years after above knee amputation, two died rapidly and two were lost to follow up. It is concluded that the incidence of post-radiation sarcoma is low but also that non-malignant tumours such as giant-cell tumours should never be treated by more than 1500 rads.

Adolescent↗
PubMed1981

[Palliative nephrostomy in kidney congestion due to kidney neoplasms. Ethical aspects in decision making].

The decision to perform a percutaneous nephrostomy in a tumor patient with bilateral ureteral obstruction or not, must be taken very carefully and critically, according to the individual prognosis. It should be stressed that under certain circumstances it thoroughly corresponds with our ethical rules and the law to renounce the technical solution in favour of a humane dying.

Attitude to Death↗
PubMed1981

[Bladder cancer].

Explore the source record for details and available documents.

Adenocarcinoma↗
PubMed1981

Is urinary cholesterol determination a possible screening test for urological carcinomas?

It has been suggested that the determination of urinary cholesterol may be of possible value in the diagnosis of urogenital carcinomas, especially of the prostate, kidney and bladder, but it has not proven whether this method could be used as a screening test in large numbers of patients. 430 males and 545 females over 50 years old were selected for the study. Total urinary cholesterol values exceeding the upper 3 SD limit of 5. 1 mg/24 h (regarded as positive results) were present in 13 males (3%) and 9 females (1.6%). Besides benign diseases of the kidney and the urogenital tract, 2 carcinomas of the bladder and 1 carcinoma of the kidney were detected in the male group with elevated urinary cholesterol excretion. In view of the expensive methodology and most importantly because of the low prevalence of urological carcinomas in unselected populations this method cannot be recommended as a primary screening test. This does not exclude the possibility that urinary total cholesterol determinations could be successfully applied in preselected populations with an increased prevalence of urological carcinomas.

Aged↗
PubMed1981

Histamine content in human kidneys with hypernephroid carcinoma. Is there a pathophysiological mechanism?

The hypernephroid carcinoma is the most common tumour of the kidney in adults. Haematuria can occur, even in the early developmental stages. In investigations of 30 patients with-haematuria, radiological examinations were made and the plasma histamine levels were determined in both from the renal artery and vein, the vena cava and the aorta. After nephrectomy, the histamine content of various tissues in different regions of the kidney were investigated. Significant increases of plasma and tissue histamine levels were found in the veins of the tumour-riddled kidney and in the tissue surrounding the tumour. an experimental study on dogs investigated whether or not an injection of histamine into the renal artery would provoke haematuria. Dose-dependent haematuria occurred, which was most pronounced following intra-arterial injection of 25 micrograms/kg of histamine.

Adenocarcinoma↗
PubMed1981

Urinary cholesterol in follow-up of patients with urologic carcinomas or benign prostatic hyperplasia.

Urinary cholesterol was determined in follow-up in 2 patients with prostatic adenoma, 3 patients with prostatic carcinoma, 3 patients with carcinoma of bladder, and 4 patients with carcinoma of kidney. All patients revealed marked urinary cholesterol hyperexcretion prior to surgery. Except for 1 patient with prostatic carcinoma, excretion of urinary cholesterol normalized at least six weeks after resection. In 1 remarkable case a localized recurrence of a transurethrally resected bladder tumor was associated with a marked increase of urinary cholesterol excretion six weeks prior to cystoscopy. The results point to a possible future value of this method in monitoring patients with bladder tumors, although additional studies are necessary.

Aged↗
PubMed1980

A colchicine-sensitive uptake system in Morris hepatomas.

The interference of microtubular disruptors with the uptake of amino acids and other low molecular weight substrates has been studied in Morris hepatomas, host liver, and regenerating liver. Colchicine inhibits amino acid transport (alpha-aminoisobutyric acid, L-methionine, and L-leucine) in hepatomas by 59-98% whereas transport in host and regenerating liver is not impeded but increased. In hepatomas, treatment urea, and carbonate. Vinblastine, but not lumicolchicine or cytochalasin B, is an effective inhibitor. The inhibition of uptake is not linked to a decrease of cellular ATP and UTP. The data suggest that the transport of low molecular weight substrates in hepatomas is related to microtubules or other colchicine-binding structures, e.g., of the plasma membrane. This colchicine-sensitive uptake system in hepatomas may be due to the malignant transformation of hepatocytes.

Amino Acids↗
PubMed1979

[Lymph node metastases--diagnosis by lymphography and CT (author's transl)].

The value of lymphography and CT in the diagnosis of abdominal lymph node metastases was compared in 82 patients with various types of malignant disease. In the presence of systemic disease or testicular tumours, CT increased the recognition of lymph node metastases and their extent, particularly of high para-aortic deposits which were frequently underestimated by lymphography. Lymph nodes in the pelvis are more easily identified. CT is the first choice for the investigation of systemic disease and testicular tumours. This will, in addition, also demonstrate abnormalities of the organs and assist in radiation planning. CT is a simple procedure which is also very valuable in following the effect of treatment. For metastases from other origins, lymphography is often more valuable since CT is unable to identify metastases in lymph nodes if these are not enlarged. The two methods complement each other and their combination provides improved diagnostic information.

Carcinoma, Squamous Cell↗
PubMed1979

[Animal experimental studies on partial kidney function after temporary tourniquet ischemia with and without blood substitute therapy].

70 rats were subjected to tourniquet ischemia of a hind limb for a period of two and three hours. 12 rats served as controls. After release of the 3 hours tourniquets 20 rats were treated either with Ringer's solution or with hydroxyethyl starch. Kidney function and morphology, systolic blood pressure, hematocrit, serum electrolytes, creatinine and urea were studied as different times of recirculation. 1. Reduction in renal function was only observed after releasing the tourniquets. 2. The extent of reduction in renal function depended on the time of ischemia and time of recirculation. 3 hours of tourniquet with two hours of recirculation led to the largest extent of reduction in renal function and renal parenchymal lesions. 3. If the infusion of HES was applied at the beginning of recirculation, reduction in renal function was prevented, as well as parenchymal lesions. Ringer's infusion, however, did not improve kidney function to a normal range.

Animals↗