Conformity and achievement-related characteristics of depressed patients.
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Achievement↗
Biomedical subjects
R Tan
Publications and source records attributed to R Tan.
Synthesis of 2,6-naphthyridine and some of its derivatives.
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Chemical Phenomena↗
Severe plasmalogen deficiency in tissues of infants without peroxisomes (Zellweger syndrome).
The Zellweger syndrome is a lethal hereditary disease characterized by the absence of peroxisomes (microbodies) in liver and kidney, and variable abnormalities in mitochondria. We show here that tissues from five infants that had died of this syndrome contain less than 10% of the normal levels of phosphatidylethanolamine plasmalogen (pPE), a major phospholipid component of cellular membranes. Heart and muscle, but not other tissues, also contain a substantial fraction of phosphatidylcholine plasmalogen (pPC), and this fraction is also strongly reduced in the Zellweger patients. No other abnormalities in cellular phospholipids were detected. Key enzymes of the biosynthesis of plasmalogens have previously been shown to be exclusively located in the peroxisomes of rodent liver and the microperoxisomes of rodent brain. We infer that the corresponding enzymes are also located in peroxisomes in man and that the absence of peroxisomes in Zellweger patients leads to their inability to synthesize plasmalogens. Our results support the notion that the biosynthetic role of peroxisomes in mammals has thus far been underestimated. We suggest that the defect in plasmalogen synthesis and possibly as yet unknown peroxisomal reactions are responsible for the diverse abnormalities observed in Zellweger patients.
Abnormalities, Multiple↗
The role of chemoradiotherapy in maintaining quality of life for advanced esophageal cancer.
From May 1996 to July 1996, three male patients with advanced esophageal cancer with complete obstruction were treated with concurrent chemoradiotherapy. The first two courses of chemotherapy using 5-Fluorouracil (500 mg/m2) and Leucovorin (200 mg/m2) on day one through day five were given concurrently with radiotherapy. After completion of radiotherapy, four more courses of chemotherapy using the same regimen were given every four weeks. The total dose of irradiation using six MV linear accelerator given to the primary tumor was 5,000 cGy in 28 fractions. All three patients had relief of their obstruction with complete regression of the tumor after the completion of their treatment. All patients improved clinically and were able to remain symptom-free until the time of their death. The first patient survived for 12 months and died of respiratory failure because of his chronic obstructive pulmonary disease. The second patient also survived 12 months but died of liver metastasis. The third patient lived for 10 months and died of aspiration pneumonia.
Aged↗
Some clinical and epidemiological observations on virologically confirmed dengue hemorrhagic fever.
This study is a part of a one year prospective study on dengue hemorrhagic fever (DHF) carried out in the Department of Pediatrics, Sumber Waras Hospital in West Jakarta. Viral isolation and serologic analysis for DHF were done by Namru-2 in Jakarta. The subjects were 151 virologically confirmed DHF Patients admitted to the Department of Pediatrics during the period of September 1987-June 1988, consisting of 82 boys and 69 girls of 6 months-15 years old. The predominant age group was 5 to 9 years, representing 49.7% subjects. Dengue virus was isolated from sera during the first 8 days of illness and in 139 (42.1%) during the first 5 days of illness. Dengue virus type 1, 2, 3 and 4 were isolated from 16.6%, 13.2%, 69.5% and 0.7% subjects, respectively. The clinical manifestations revealed no striking differences between dengue 3 and others except for thrombocytopenia and shock. High fever, hemoconcentration and thrombocytopenia on admission was observed in 30.5%, 8.6% and 8.6% of subjects, respectively. Dengue shock syndrome (DSS) were observed in 23 (15.2%) with 3 (2%) fatal cases. Dengue virus serotype 3 was observed in 20 out of 23 DSS cases (86.9%) and all fatal cases were associated with dengue type 2. This study revealed that dengue 3 is the predominant virus circulating during recent epidemics and is associated with more severe clinical manifestation and with a higher incidence rate of living area.
Adolescent↗
Sharps utilization and disposal in British Columbia physicians' offices.
To determine the pattern of sharps utilization and disposal in British Columbia physicians' offices, a questionnaire was mailed to all office-based physicians belonging to the British Columbia Medical Association (BCMA). 1,167 physicians (25%) responded. Over 166,000 sharps per month were used by responding physicians, a per physician use of 95 per month. 67% of physicians used a specific plastic container for sharps disposal and 22% used a recycled container. 40% of the used containers were returned to a hospital or laboratory for disposal; 29% contracted out to a waste removal company, 18% placed with regular office garbage and 4% taken directly to a landfill or incinerator. Most offices (64%) had access to an autoclave or chemclave but few physicians (2%) sterilized their sharps waste prior to disposal. The recommended options for discarding used sharps containers in the office setting are: return to a hospital or laboratory for processing with their infectious waste; removal by a waste disposal service; or sterilization followed by disposal with regular garbage.
British Columbia↗