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Biomedical subjects

R T White

Publications and source records attributed to R T White.

40 records · Page 3Linked to original sources
PubMed1974

Stereotactic amygdaloidotomy for aggressive behaviour.

Amygdaloidotomy was performed bilaterally on 15 and unilaterally on three patients exhibiting severe aggressive or self-mutilating behaviour. Nine subjects (50%) were improved a year after operation; improvement was maintained in seven (39%) for periods ranging from 27 months to nearly six years. Four non-epileptic cases had convulsions during the period of review; one of them has a persistent mild hemiparesis dating from the postoperative period. There was a tendency for epileptics to respond better than non-epileptics and for mentally retarded patients to respond poorly, but none of the differences was statistically significant.

Adolescent↗
PubMedDate not supplied

Isolation and characterization of the human pulmonary surfactant apoprotein gene.

Pulmonary surfactant is a phospholipid-protein complex which serves to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Inadequate levels of surfactant at birth, a frequent situation in premature infants, results in respiratory failure. In all species examined, surfactant is composed primarily of dipalmitoylphosphatidylcholine and two major protein species of relative molecular mass (Mr) 32,000 (32K) and 10K (refs 2-5). Reconstitution in vitro of purified 32K pulmonary surfactant apoprotein (PSAP) with synthetic lipids forms a lipoprotein complex that lowers surface tension by spreading to create a thin interfacial film. Here we describe the cloning of the human PSAP gene and complementary DNA, and discuss features of the unusual encoded protein.

Amino Acid Sequence↗
PubMedDate not supplied

The ovoid lesion: a new MR observation in patients with multiple sclerosis.

We investigated the frequency of oval-shaped, high-signal-intensity lesions oriented perpendicular to the anteroposterior axis of the brain on abnormal, axial T2-weighted MR brain scans in 59 patients with clinically documented multiple sclerosis. This finding, not heretofore described in patients with multiple sclerosis, was observed in 86% of patients, and correlates with the neuropathologic description of demyelination in multiple sclerosis.

Adolescent↗