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Biomedical subjects

R T Rada

Publications and source records attributed to R T Rada.

At least 19 recordsLinked to original sources
PubMed1979

The effects of chlordiazepoxide on self-rated depression, anxiety, and well-being.

The main purpose of this study was to compare sensitivity of several self-rating scales to drug effects in anxious and depressed patients. Twenty-two distressed nonpsychotic outpatients completed a double-blind crossover trial of chlordiazepoxide and placebo. All self-rating scales of depression, anxiety, somatic symptoms, and feelings of inadequacy discriminated significantly between chlordiazepoxide and placebo. The decrease in self-rated depression was about equal to the decrease in self-rated anxiety. Subscales describing well-being were more sensitive to drug effects than subscales describing symptoms. A questionnaire (The Symptom Questionnaire) and one of the self-rating scales (Symptom Rating Test) were more sensitive than global self-rating scales, global observer-rating scales, and the Hamilton Anxiety Rating Scale. Some of the self-rating scales discriminated significantly between drug and placebo even when the sample size was reduced to two subsamples of eight patients each. High and significant positive correlations between two scales did not indicate equal sensitivity in discriminating between drug and placebo.

Adult↗
PubMed1978

The effects of one-day treatment of anxiety with high doses of halazepam.

The main purposes of this study were to examine the effects of one-day treatment of anxiety and to test whether significant relief of anxiety can be achieved in a short time period by frequency individual adjustment of doses. A double-blind crossover study of halazepam and placebo was carried out with 22 patients, 20 completing the study. Each treatment lasted for one day. Oral medication was administered starting with a dose of 40 mg and the dose adjusted every 2 hours. The total daily dose did not exceed 600 mg. Several rating and self-rating scales were used. All observer rating scales and several self-rating scales discriminated at a significant level. The design appeart to be suitable for the rapid screening for anti-anxiety properties of new drugs.

Adult↗
PubMed1978

Incest hoax: false accusations, false denials.

Expertise in investigating incest accusations is essential for psychiatrists because the law requires the reporting of sexual abuse of children. In such cases persistent and methodical investigation tends to yield a consensually credible view of what really happened without resort to special forensic techniques of truth-finding. In order to make a diagnosis of incest hoax, the investigator must thoroughly understand the mechanics of the hoax and the psychodynamics of the perpetrator. Failure to recognizing a delusional hoax can delay treatment for the perpetrator of the hoax. Failure to recognize a child's fabrication can subject the family to unnecessary legal action and unwittingly support the use of a similar manipulative technique by other susceptible children. Failure to recognize the false retraction of an incest accusation may leave the victim in danger of further sexual abuse or of physical punishment for having revealed the secret.

Adolescent↗
PubMed1976

A pilot study of the short-term psychotropic effects of GPA 2640.

Thirty-two anxious nonpsychotic inpatients participated in a four-day, double-blind repeat crossover study of a new drug, GPA 2640, and placebo. Each treatment period lasted for one day, and the study lasted for four days. Twenty patients completed the study, and 28 completed two or three days. The doses were individually adjusted and mostly ranged between 1100 and 1300 mg daily. Several valid observer-rating and self-rating scales were used. There was a slight trend for GPA 2640 to yield somewhat lower anxiety scores on drug days than on placebo days, but none of the differences between rating and self-rating scores reached a significant level. A few patients reported a marked improvement in mood after two to four days, but the significance of this finding cannot be evaluated from this design. Two patients developed temporary paranoid delusions which may have been drug related. Two patients had raised SGOT levels after the study. There were no significant differences in vital signs between drug days and placebo days. The results signify that the drug has no immediate antianxiety effects (such as have been demonstrated with benzodiazepines in two previous studies utilizing the same design). This does not preclude the possibility of delayed anxiolytic effects or of other delayed psychotropic effects such as can be observed with antipsychotic drugs or antidepressants.

Adult↗
PubMed1976

Issues in developing quality aftercare clinics for the chronic mentally ill.

Two large aftercare clinics were established to provide treatment and rehabilitative care for a chronic mentally ill population requiring neuroleptic drugs. The clinics have evolved rapidly and expanded their service over the past 3 years but have required constant monitoring and modification in order to provide quality as well as quantity care in the community setting. These modifications are described and the importance of further community-based investigation in the rehabilitation and treatment of the chronic mentally ill is stressed.

Aftercare↗
PubMed1976

Thiothixene in the treatment of geriatric patients with chronic organic brain syndrome.

Thiothixene was used in a four-week double-blind placebo-controlled study of 42 geriatric patients with chronic organic brain syndrome (psychotic or nonpsychotic). The results, according to several rating measures, showed no significant difference between placebo and thiothixene. Side effects were mild and few. These data support the safety of thiothixene therapy for geriatric patients; however, there is no conclusive evidence of its efficacy in the treatment of chronic organic brain syndrome.

Aged↗
PubMed1976

Alcoholism and the child molester.

This study shows a high association among drinking, alcoholism, and child molestation. Forty-nine percent of the child molesters were drinking at the time of commission of the offense, and 34% were drinking heavily, defined as 10 or more beers or the equivalent. The alcoholism rate for the group was 52% based on the MAST or 33% based on the more stringent Pokorny shortened version of it. An interesting and unexpected finding was a statistically significantly lower incidence of drinking at the time of commission of the offense in male-child molesters compared with female-child molesters. In addition, the male-child molesters had a definitely lower alcoholism rate compared with female-child molesters. The importance of these findings for treatment programs is emphasized.

Adult↗
PubMed1976

Depression and the reintegration phase of acute schizophrenia.

The authors found moderate to severe depression in 60% of a group of schizophrenic patients experiencing acute decompensations (N=30). The course of the depression was followed over an 8-week period8,during which patients were treated with depot fluphenazines. There was a statistically significant reduction in depression that closely paralleled the correction of the cognitive disorder. The authors discuss problems in identifying and quantifying depression during acute schizophrenic decompensation and suggest that the Hamilton scale anxiety/depression factor and the BRPS depression factor may be useful diagnositc tools.

Acute Disease↗
PubMed1975

Alcoholism and forcible rape.

Data collected from detailed autobiographies of 77 convicted rapists revealed that 50 percent of them were drinking at the time of the rape and that 35 percent were alcoholics. This strong association between alcoholism and forcible rape highlights the importance of follow-up treatment programs for the alcoholic sex offender; such programs should focus on adequate control of his drinking behavior as well as on his sexual adjustment.

Adult↗