Biomedical subjects

R T Miller

Publications and source records attributed to R T Miller.

111 records · Page 7Linked to original sources

PubMedDate not supplied

Time- and dose-dependent development of potassium bromate-induced tumors in male Fischer 344 rats.

Potassium bromate (KBrO3) is a rodent carcinogen and a nephro- and neurotoxicant in humans. KBrO3 is used in cosmetics and food products and is a by-product of water disinfection by ozonization. KBrO3 is carcinogenic in the rat kidney, thyroid, and mesothelium and is a renal carcinogen in the male mouse. The present study was designed to investigate the relationship of time and dose to bromate-induced tumors in male Fischer 344 (F344) rats and to provide some insight into the development of these tumors. KBrO3 was dissolved in drinking water at nominal concentrations of 0, 0.02, 0.1, 0.2, and 0.4 g/L and administered to male F344 rats as the sole water source for 12, 26, 52, 78, or 100 wk. Renal cell tumors were present after 52 wk of treatment only in the high-dose group. Mesotheliomas developed after 52 wk of treatment on the tunica vaginalis. Mesotheliomas were present at sites other than the testicle after 78 wk of treatment, indicating that their origin was the testicular tunic. Thyroid follicular tumors were present as early as 26 wk in 1 rat each from the 0.1- and 0.2-g/L groups. The present study can be used as a basis for the determination of dose-time relationships of tumor development for a better understanding of KBrO3-induced cancer.

Adenoma↗

PubMedDate not supplied

Management and complications following trigonal-colonic anastomosis in a dog: five-year evaluation.

Urinary diversion procedures in the dog have been described for both benign and malignant processes involving the bladder, urethra, or both. These procedures are performed rather infrequently, primarily because of the potential complications associated with urinary diversion into an intact gastrointestinal system. A case managed for five years following trigonal-colonic anastomosis for lymphocytic-plasmacytic urethritis is presented, along with a review of urinary diversion techniques. Postoperative management recommendations following urinary diversion are discussed.

Anastomosis, Surgical↗

PubMedDate not supplied

Multilobated B-cell lymphoma. Report of a case with immunocytologic diagnosis in pleural fluid.

The cytologic, histologic and immunocytochemical findings in an aggressive case of multilobated lymphoma in an 89-year-old man are described. This unusual variant of non-Hodgkin's lymphoma is morphologically distinct but may be of either T-cell or B-cell origin. A battery of immunocytologic stains on pleural fluid specimens allowed determination of a B-cell (follicular center cell) origin to be made. Previous literature on this neoplasm is briefly reviewed, and the unreliability of morphologic findings in predicting a T-cell or B-cell origin is discussed.

Aged↗