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Biomedical subjects

R T Gregor

Publications and source records attributed to R T Gregor.

56 records · Page 4Linked to original sources
PubMedDate not supplied

Supraglottic laryngectomy with postoperative radiation versus primary radiation in the management of supraglottic laryngeal cancer.

PURPOSE: The purpose of this review was to study the results of horizontal partial laryngectomy (HPL) for supraglottic laryngeal cancer (stages N0 and N+) and the effects and morbidity of postoperative radiation therapy (RT), especially after bilateral neck dissection, as opposed to primary RT. PATIENTS AND METHODS: Of a total of 89 patients, 26 were treated by HPL, 44 by primary RT, and 19 by total laryngectomy (TL). Of the HPL patients, 19 of 26 had neck dissection, 10 were bilateral. Twelve of the patients received postoperative RT, and 10 of 12 procedures were combined with neck dissection. RESULTS: When comparing the results of HPL and primary RT, the locoregional control was equivalent for the N0 patients, but HPL showed better results in locoregional control for the N+ patients (P < .0024). Postoperative RT with or without bilateral neck dissection did not show an increase in postoperative morbidity. CONCLUSION: Therefore, our data suggest that there should be no hesitation in giving postoperative RT where indicated, after performing HPL plus unilateral or bilateral neck dissection. Patients that are stage N0 should receive primary RT.

Humans↗
PubMedDate not supplied

Respiratory function in post-laryngectomy patients related to stomal size.

Thirty-nine laryngectomized patients from the Professorial Unit of The Royal National Throat, Nose and Ear Hospital, London, were recalled between 6 months and 18 years after operation. The tracheal and stomal diameters were measured and, in addition to a full general examination, respiratory function tests (including arterial blood gas estimations) were performed. Most patients had impaired respiratory function tests which were in excess of the expected impairment due to age alone. The study suggests that impaired function is due to intercurrent pulmonary and cardiovascular diseases, rather than anatomical factors related to the changed upper airway. There was no correlation between stomal size or tracheal/stomal cross sectional area ratio and the measured respiratory function.

Adult↗