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Biomedical subjects

R T Go

Publications and source records attributed to R T Go.

At least 73 records · Page 4Linked to original sources

Nuclear magnetic resonance (NMR) imaging in the evaluation of the liver: a preliminary experience.

To determine the usefulness of nuclear magnetic resonance (NMR) in evaluation of the liver, 19 examinations were performed. A variety of pathological conditions were examined, and correlation was obtained with computed tomography, ultrasound, and radionuclide liver/spleen scanning. Nuclear magnetic resonance was as sensitive as the correlating imaging modalities in the detection of focal disease. Parenchymal abnormalities could be detected only in hemochromatosis. Several patients with diffuse disease did demonstrate evidence of portal hypertension, but no characteristic findings were noted within the liver parenchyma. Our preliminary investigation did not include T1 and T2 values and it is hoped that these will allow greater diagnostic utility in the detection of diffuse parenchymal disease.

Hemochromatosis↗

Recirculation subtraction for analysis of left-to-right-cardiac shunts: concise communication.

The object of this study is to improve the techniques for describing the lung dilution curve for shunt quantification by separating the effects of systemic recirculation on the curve form those of direct shunt return. The time of the systemic recirculation peak was estimated by determination of transit times from the right and left ventricles and lung. A gamma variate fit based on the distribution of points at that segment was applied to the recirculation curve and subtracted from the original lung dilution curve. Similar gamma variate fitting was performed for both primary and shunt curves. Rather than fitting the gamma variate of the shunt curve by the leading edge only, a larger portion could now be used since the trailing edge of the curve is clearer following recirculation subtraction. The algorithm is completely automatic, requiring no operator intervention or selection of curve-fitting regions. The correlation coefficient for comparison of the dilution-curve analysis with oximetry determinations was 0.92 in a series of 29 patients.

Adolescent↗

Radionuclide bone image in growing and stable bone island.

A normal radionuclide bone image can facilitate distinction between a bone island and significant pathologic processes, especially an osteoblastic metastasis. This distinction becomes more crucial when growth is detected in an isolated sclerotic bone lesion or if a relatively large sclerotic lesion is detected de novo in patients with a known neoplasm. This report presents three patients with isolated bone islands: two with interval growth, the other with a relatively large stable lesion; all showing a normal radionuclide bone image.

Acetabulum↗

Sonographic features of xanthogranulomatous pyelonephritis.

The ultrasonic findings of three patients with surgically confirmed xanthogranulomatous pyelonephritis are presented. All of the involved kidneys were markedly enlarged, had a large central echogenic area, and demonstrated an increased parenchymal anechoic pattern. The appearance correlated well with the other radiographic and gross pathologic findings. While this appearance was fairly distinctive, it is anticipated that there will be some difficulty in distinguishing this entity from simple hydronephorsis, especially in conjunction with staghorn calculus. It is also anticipated that focal xanthogranulomatous pyelonephritis will have an atypical appearance.

Adolescent↗

Cranial CT of neurofibromatosis.

The results of computed tomography (CT) of the orbits and brain of 29 patients with neurofibromatosis were reviewed to determine the contribution of CT scanning to the diagnosis of this disorder. In the presence of orbital symptoms, CT confirmed the presence of suspected lesions such as optic nerve gliomas, demonstrated asymptomatic and atypical lesions, and displayed concomitant intracranial involvement of the optic chiasm. CT of the brain revealed a multiplicity of abnormalities such as astrocytomas, intracerebral calcification, hydrocephalus, and congenital lesions.

Adolescent↗

The role of radionuclide brain imaging and computerized tomography in the early diagnosis of herpes simplex encephalitis.

We have reviewed the medical records and radiographic examinations of 12 patients with herpes simplex encephalitis to assess the role of RN and CT in the early diagnosis of this disease. The initial RN study was positive in 83% (10/12) of cases while the initial CT study was positive in 75% (9/12) of cases. The earliest positive RN was seen on the second day after the onset of neurologic signs or symptoms while the earliest positive CT was seen on the third day. We describe various abnormal patterns encountered in HSE and discuss their diagnostic reliability. We make recommendations for the diagnosis of HSE based on our findings and on the information available in the literature

Adult↗

Computed tomography in cerebral hemiatrophy.

The clinical and radiographic findings in four cases of cerebral hemiatrophy are presented. CT findings reflect the underlying gross pathologic changes and are in agreement with those seen on plain skull radiography and pneumoencephalography. The most impressive finding was unilateral loss of cerebral volume with ipsilateral displacement of the midline structures. The differential diagnosis primarily includes Sturge-Weber syndrome and linear sebaceous nevus syndrome. The recognition of compensatory calvarial changes should indicate that the cerebral abnormalities are the result of an atrophic or hypoplastic process that began in early life.

Adolescent↗

Computed tomography and radionuclide studies in the diagnosis of intracranial disease.

The accuracy of CT and radionuclide studiies in the diagnosis of intracranial disease is analyzed based on experience in 641 patients. Results indicate that both modalities give reasonably similar precision and that a modest improvement in diagnosis can be expected if both techniques are employed. It is emphasized that the radionuclide studies used routinely included what are rightfully considered adjunctive scanning procedures, so that results must be considered in this light.

Brain Diseases↗

Sequential brain scanning as an adjunctive scanning procedure.

Sequential brain scans were performed at various time intervals of up to four hours after injection of 99mTc pertechnetate in 108 patients who had previously undergone "routine" one-hour brain scans which were considered normal or equivocal. Forty-six patients were proved to have a discrete morphologic brain lesion. Pathologic processes were demonstrated by the sequential scanning technique in all but 6 cases. In nearly a third of these 46 patients (28%), careful observation of the progressive and subtle changes in radioactivity in the whole sequential scan series was necessary for detection of the lesions: they could not be appreciated on any single static scan when viewed independently.

Adenoma, Chromophobe↗

The manifestations of diaphragmatic and juxtadiaphragmatic diseases in the liver-spleen scintigraph.

Diaphragmatic and juxtadiaphragmatic abnormalities can be recognized on liver-spleen scintigraphs by alteration of the normal disparity in height between the liver and the spleen and by flattening of the superior margins of the liver and spleen. A unilateral abnormality is manifested by exaggeration or reversal of the normal disparity in height between the superior margins of the liver and spleen by cephalad or caudad displacement of one of these organs. Bilateral peridiaphragmatic abnormalities are manifested by flattening of the superior margins of the liver and spleen by caudad displacement of both organs.

Diaphragm↗

A new method of diagnosing myocardial contusion in man by radionuclide imaging.

A new method of diagnosing myocardial contusion was studied in 8 patients in whom the injured mycardium was visualized as an abnormal area of increased activity in the region of the heart one hour after intravenous injection of 10 mCi of 99m-Tc-Sn-polyphosphate or pyrophosphate. Serum enzymes in these patients were elevated, but electrocardiograms were nonspecific for myocardial injury. It is hoped that this new technique of imaging the injured myocardium will provide specific and confirmatory diagnosis of myocardial contusion associated with closed chest injuries.

Animals↗

Coronary angiographic and scintigraphic findings in experimental cardiac contusion.

Clinical, angiographic, scintigraphic and pathologic observations in myocardial contusion were correlated. Radionuclide imaging of the injured heart with 99mTc-Sn-polyphosphate provides an accurate diagnosis in acute, even mild, myocardial contusion. The study can be carried out without danger to the critically ill patient. The coronary angiographic findings in this study explain what is occurring pathologically in the heart. Since arteriography is a more invasive technique than radionuclide imaging, its use is recommended only when the image is negative if it is neccessary to establish the clinical diagnosis for treatment or when more than one week has elapsed since the injury.

Acute Disease↗

The diagnostic value of serial brain scanning.

A survey of the literature pertaining to several serial brain scanning procedures has been presented. These procedures include rapid brain imaging, sequential brain imaging, delayed from imaging, and follow-up brain imaging. Applications of these techniques to specific clinical problems have been stressed and the reported results reviewed. Thus, it has been indicated that rapid brain imaging is most useful in detecting lesions secondary to cerebrovascular disease but may also provide some helpful information pertaining to the differential diagnosis of other C.N.S. lesions demonstrated on subsequent static brain scans. Sequential brain imaging is a time-consuming adjunctive procedure which, however, can be extraordinarily helpful in a highly selected group of problem cases which present with relatively small lesions adjacent to normal anatomic structures which themselves have considerable radioactivity. Delayed brain imaging has the distinction of detecting the greatest number of intracranial lesions but is attended by tactical problems in maintaining an optimal patient flow through the department and also has the undesirable consequence of reduced information density and diminished image quality, unless greater radiation doses are injected. Follow-up brain imaging is useful in the differential diagnosis of cerebrovascular and neoplastic disease and in the assessment of effectiveness of radiation therapy.

Adenoma, Chromophobe↗