Biomedical subjects

R Sykes

Publications and source records attributed to R Sykes.

21 records · Page 2Linked to original sources

PubMed1984

Discovery, purification and characterization of the angiotensin converting enzyme inhibitor, L-681,176, produced by Streptomyces sp. MA 5143a.

L-681,176, an inhibitor of angiotensin converting enzyme was found in the culture filtrate of Streptomyces sp. MA 5143. The I50 of the crystalline inhibitor is about 1.3 micrograms/ml and the inhibition is reversed by zinc sulfate. In rats, L-681,176 exhibits a dose-related inhibition of the pressor response to angiotensin I with an ID50 of 142 mg/kg when administered intravenously. The structure of L-681,176 is similar to that of marasmine but lacking one carboxyl group. The maximum yield of L-681,176 occurs after three to four days growth at 28 degrees C.

Angiotensin-Converting Enzyme Inhibitors↗

PubMed1981

Spirometric standards for healthy black adults.

Forced expiratory spirometric studies were performed on 512 nonsmoking black adult men and women with negative cardiorespiratory histories. Regression equations were calculated for forced vital capacity (FVC), percent vital capacity in 1 second (% FEV(1)), and forced midexpiratory flow rate FEF(25-75)%), using height and age. These equations resulted in predicted values 3.5 to 23 percent lower than commonly used standards. The wide range of variation means that a single correction factor is inadequate when considering ethnic differences. In contrast, FEV(1)/FVC was within the accepted range of normal for all ethnic groups. In the 30 percent of subjects in whom sitting height was measured, it was not significantly different from one half the standing height; thus, sitting height is also an inadequate correction factor. Tables of predicted values were constructed for easy reference, with the hope that use of racespecific standards for pulmonary function testing will become widespread.

Adult↗

PubMedDate not supplied

Sampling for vaginal candidosis: how good is it?

In defined patient populations attending a genitourinary medicine department, screening for vaginal candidosis resulted in 26.3% positive rate. Microscopy using Gram-stained slide was useful in early diagnosis and resulted in the detection of 64.8% of symptomatic cases. Samples from the anterior fornix proved most sensitive for culture diagnosis while the left lateral vaginal wall proved least sensitive (positive predictive value 0.88 cf 0.81).

Candidiasis, Vulvovaginal↗