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Biomedical subjects

R Sweet

Publications and source records attributed to R Sweet.

59 records · Page 4Linked to original sources
PubMed1975

Residency training in primary care internal medicine. Report of an operational program.

The Primary Care Program at the Massachusetts General Hospital is designed to develop competence in the full range of problems encountered by general internists delivering primary care. House staff spend 3 years in the program, which starts with internship, includes a senior residency, and fulfills the requirements for board eligibility in internal medicine. Half of the training is provided in outpatient care settings. House staff assume responsibility for organization and operation of an ambulatory medical unit. In addition, there is supervised instruction in office gynecology, orthopedics, ear, nose and throat, dermatology, and psychiatry. Close integration with the traditional inpatient-oriented training program is maintained to ensure commensurate growth and competence in management of acute, life-threatening disease.

Boston↗
PubMed1971

Decrease of the 3,4-dihydroxyphenylalanine (DOPA) decarboxylase activities in human erythrocytes and mouse tissues after administration of DOPA.

Human erythrocytes have been found to contain appreciable amounts of DOPA decarboxylase (EC 4.1.1.26) activity. The enzyme activity in erythrocytes from patients with Parkinson's disease who were treated with DOPA was significantly lower than that of untreated patients and of normal individuals. Administration of the drug to mice led to a marked decrease of DOPA decarboxylase in liver and kidney, but not of the brain enzyme. The findings thus indicate that administration of DOPA leads to a decrease in peripheral DOPA decarboxylase, an effect that is expected to be of benefit in DOPA therapy of patients with Parkinson's disease. Peripheral DOPA decarboxylase concentration also decreases in mice after short periods of fasting; the findings suggest that the peripheral enzyme activities may be affected by various nutritional and perhaps hormonal influences, which may be partially responsible for the observed fluctuations in the motor abilities of Parkinsonian patients receiving constant doses of the drug. Study of DOPA decarboxylase activity in erythrocytes may be useful in following changes in patients receiving DOPA therapy and may also be of general interest and value in investigations of catecholamine metabolism in man.

Age Factors↗
PubMedDate not supplied

Passages: fact or fiction?

Four large surveys were examined to establish the existence of "passages" through the use of objective methods. Such passages are the boundaries between age groups formed on the basis of minimum within-group variation and maximum between-group variation. Results from all four data sets indicated that such age groups and their associated passages can be identified. These passages were stable across two surveys taken in the same population at about the same time, even though the surveys measured divergent attitude dimensions. The passages appear to progress with time: two surveys taken seven years apart demonstrated a seven-year shift in passages. However, the passages are not stable across cultures: two surveys taken at about the same time in Canada and the United States showed no similarity of passages. It would appear that developmental schemes as presently espoused by psychologists are inadequate to explain these results, and that the "generational event" theory provides a better model for explanation.

Adolescent↗