Search PubMed⌕ Search

Biomedical subjects

R Suri

Publications and source records attributed to R Suri.

At least 37 records · Page 2Linked to original sources
PubMed1999

Pilot open-label study of nefazodone in panic disorder.

Ten patients meeting DSM-IV criteria for non-comorbid panic disorder or panic disorder with agoraphobia were treated in a 12-week open-label, flexible dosage trial of nefazodone. Dosages ranged from 50 to 400 mg per day. Clinical assessment utilized several recently developed scales of panic disorder severity, as well as the clinical global impression scale. At the conclusion of the study, 9 out of 10 patients were rated much improved with 7 of the patients rated as panic free and in full remission. Significantly improved scores were reflected by all of the scales. Low sample size and absence of placebo control indicate the need for a large placebo-controlled trial. The results of this pilot study suggest that nefazodone may be promising in the treatment of panic and justify further research.

Adult↗
PubMed1998

Ultrasound guided fine needle aspiration cytology in abdominal tuberculosis.

Although barium studies and CT are useful in assessing abdominal pathology in tuberculosis, imaging findings are not always specific and a histopathological or bacteriological confirmation is often required. The aim of the present study was to evaluate the role of ultrasound (US) guided fine needle aspiration cytology (FNAC) in the diagnosis of abdominal tuberculosis in patients with non-palpable lesions detected on US/CT. FNAC was performed on 31 sites in 30 patients. The sites included enlarged lymph nodes (n = 14), focal lesions in liver (n = 2) and spleen (n = 8), and thickened bowel in the ileocaecal region (n = 7). The results were classified cytomorphologically into four groups: (1) definite evidence of tuberculosis; (2) presumptive evidence of tuberculosis; (3) suggestive of tuberculosis; and (4) negative for tuberculosis. 18 of the 31 FNACs (58%) revealed a positive diagnosis of tuberculosis (definite evidence in nine patients and presumptive evidence in nine patients). 13 of the 31 FNACs (42%) showed either necrosis alone (n = 4) or negative results (n = 9). Zeihl-Neelson staining for acid-fast bacilli on direct smear was positive in only nine patients (29%). Splenic and lymph nodal FNAC had a high sensitivity (87.5% and 78.6%, respectively) in the diagnosis of tuberculosis. None of the bowel and liver FNACs was diagnostic. No complications were encountered. US guided FNAC offers a safe and accurate method of achieving a diagnosis in patients with suspected abdominal tuberculosis who present with radiologically demonstrable but non-palpable lesions, especially those involving lymph nodes and spleen.

Abdomen↗
PubMed1996

Torsades de pointes from terfenadine and sotalol given in combination.

A patient receiving sotalol developed recurrent torsades de pointes following the addition of terfenadine (Seldane) to her medical regimen. A 71-year-old woman with a history of atrial fibrillation successfully suppressed with sotalol, 80 mg bid, was started on terfenadine, 60 mg bid. Eight days later, she developed repeated self-terminating episodes of torsades de pointes. Sotalol and terfenadine were discontinued, and no further arrhythmia was observed after 72 hours of temporary pacing was discontinued.

Aged↗
PubMed1995

Fluorescence properties of oxidised human plasma low-density lipoproteins.

Appearance of fluorescence emission between 380-550 nm (lambda exc 350-400 nm) in freshly prepared low-density lipoprotein from asymptomatic normolipemic human plasma revealed the presence of in vivo oxidative modification of its protein moiety. Low-density lipoprotein elicited seven fluorophores in three dimensional fluorescence spectrogram. Assignment of fluorescent chemical structures originating from oxidative modification of the protein moiety of low-density lipoprotein has been made with the help of second derivative fluorescence spectroscopy.

Adult↗
PubMed1995

Blood pressure, heart rate, and skin temperature in preterm infants: associations with periventricular haemorrhage.

The mean arterial blood pressure (MABP), heart rate, and skin temperature were monitored every 15 minutes in the first 10 days after birth in 34 preterm infants, gestational age 24 to 33 weeks. Ultrasound brain scans carried out daily showed that a periventricular haemorrhage (PVH) occurred in a subgroup of infants (n = 15) of lower birthweight and gestational age. In infants without PVH the daily median of MABP increased with birthweight and postnatal age; that of heart rate was not affected by postnatal age, body weight, or gestational age; and that of skin temperature showed a slight fall with postnatal age. In infants with PVH, on or before the day of PVH, daily medians of MABP and skin temperature were not significantly different from those of infants without PVH, but the daily median of heart rate tended to be slightly higher. The percentage of positive correlations between the 96 15 minute values per day for heart rate and MABP increased with postnatal age and with birthweight, but did not differ in infants who developed a PVH. The coefficient of variation (CV) of the 96 15 minute values for MABP tended to be higher in infants on the day of PVH, and a similar trend was apparent on the day before. The processes of development of blood pressure, heart rate, and skin temperature are similar in infants with or without PVH but at lower gestational ages altered blood pressure control may cause brain haemorrhage.

Birth Weight↗
PubMed1994

Multiple myeloma: the National University Hospital (NUH) experience.

The aim of this retrospective study was to define the characteristics of local patients with multiple myeloma. Twenty-nine de novo cases were accrued from October 1986 to January 1992 at the National University Hospital of Singapore. Features like median age of presentation, sex distribution, the incidence of IgG, IgA and light chain subtypes were similar to published data. However IgD myeloma appeared to be more common here and it tended to be more advanced at presentation. Objective response rate to treatment with the melphalan-prednisolone combination was about 40% with a median survival of 18 months.

Adult↗
PubMed1991

Prognostic usefulness of cytogenetic analysis for haematological malignancies--two case reports on acute myeloid leukaemia.

Since the setup of marrow cytogenetic analysis at the National University Hospital (NUH) of Singapore in 1988, we have systematically examined all patients with haematological neoplasia for clonal abnormalities. In most patients, diagnosis was unequivocal on clinical and morphological grounds so that karyotyping was undertaken for prognostic purposes. Two patients are described who illustrate the prognostic implications of nonrandom chromosomal derangements. They highlight the increasing appreciation of the importance of cytogenetic analysis as an independent and reliable prognostic tool in the management of haematological malignancies.

Acute Disease↗
PubMed1990

Cytogenetic analysis in myeloid malignancies.

Forty-one patients with myeloid malignancies, majority newly diagnosed and previously untreated, were systematically karyotyped between January 1988 and December 1989 using fluorodeoxyuridine (FdU) synchronisation and Giemsa banding techniques. Eighteen patients had acute myeloid leukaemia (AML), 13 had one form or other of a myeloproliferative disorder and 10 fulfilled the clinical and morphological criteria for the myelodysplastic syndrome (MDS). Ten AML patients had cytogenetic abnormalities. All 6 chronic myeloid leukaemia (CML) patients carried the Philadelphia chromosome with 2 having additional abnormal clones. Only four MDS patients showed involvement of either chromosome 5 or 7.

Adolescent↗
PubMed1990

The myelodysplastic syndromes.

The myelodysplastic syndromes are a group of diseases mainly afflicting the elderly of unknown aetiology manifesting with clinical and laboratory manifestations of ineffective haematopoiesis. This review discusses the clinical and morphological features of the syndrome followed by a critical appraisal of the French American British (FAB) group classification. The presenting symptoms are usually non-specific and relate to the peripheral cytopenia(s). The marrow is invariably hyperplastic with peripheral cytopenia(s) together with characteristic trilineage dysplastic morphological changes. Prognostic stratification and treatment are outlined. Lack of effective treatment of this syndrome remains an outstanding problem.

Humans↗
PubMed1990

Chemotherapy of adult acute myeloid leukaemia.

Great strides have been made in the chemotherapy of adult acute myeloid leukaemia in the last two decades. This paper describes our experience in the treatment of adult acute myeloid leukaemia from 1980-88. About two thirds of patients achieve remission with a standard chemotherapy protocol. Early disease relapse and measures to prevent it are major problems. The majority of patients with adult myeloid leukaemia, presently, are not cured with chemotherapy alone.

Adolescent↗
PubMed1989

Extensive bone marrow necrosis in cancer.

Extensive bone marrow necrosis is an uncommon finding in patients with cancer. This paper presents the clinical details of two patients in whom this condition was the presenting feature. The diagnostic criteria, pathogenesis and prognosis of this poorly understood problem are then discussed. Although prognosis is usually grave, prompt recognition and proper management of this condition may result in remission of the disease and regeneration of the marrow.

Adult↗
PubMed1988

Monoclonal antibodies and the lymphoid malignancies.

A comprehensive classification of the lymphoid malignancies with correlation between histology, clinical disease and with prognostic value has proved difficult to formulate, partly because of the heterogeneous nature of these neoplasms, inadequate definition of non neoplastic cells in the admixture of neoplastic cells and also as a result of the paucity of special techniques to supplement light microscopy in the study. The introduction of monoclonal antibodies against human leucocyte antigens for diagnosis in the lymphoid malignancies using the immunofluorescence or immunoperoxidase technique has provided a basic working immunological formulation and greatly advanced understanding of the biology of these diseases and the maturational staging of normal B and T lymphocytes. This review briefly looks into recent advances and presents a simplified approach to understanding this rapidly advancing field especially for clinicians.

Antibodies, Monoclonal↗
PubMed1988

Common variable immunodeficiency--a case report and review.

Common Variable Immunodeficiency is a rare primary immunodeficiency presenting usually in young adults with repeated sinopulmonary infections as a result of profound hypogammaglobulinemia. A clinical report of the first documented patient in this region is presented along with a brief review of the recent advances made especially in understanding pathogenesis and management of patients with this disorder.

Adult↗
PubMed1988

Disseminated histiocytosis X with diabetes insipidus and diabetes mellitus in an adult female (histiocytosis with DI and DM).

We report the clinical presentations and pathologic findings in an adult female who had Disseminated Histiocytosis X associated with diabetes insipidus and diabetes mellitus. The association of these three conditions in the same subject is rare. The current knowledge on Disseminated Histiocytosis X is reviewed and the possible relationship between these three conditions discussed.

Adult↗