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Biomedical subjects

R Streuli

Publications and source records attributed to R Streuli.

45 records · Page 3Linked to original sources

[Macrocytic anaemia with folic acid deficiency in hypothyroidism (author's transl)].

Three different kinds of anaemia are seen in hypothyroidism: (1) normocytic, normochromic anaemia; (2) microcytic, hypochromic anaemia; (3) macrocytic normochromic anaemia. The latter is either a true pernicious anemia, which occurs fairly frequently in Hashimoto's thyroiditis, or maturation disorder of erythropoiesis as a result of folic acid deficiency. In three patients with primary hypothyroidism and macrocytic anaemia there were decreased levels of serum folic acid. After short-term administration of folic acid and 1-year of thyroxine the blood picture became normal in two of the patients.

Adult↗

[Periosteal bone formation in Crohn's disease].

Crohn's disease not only affects the gastrointestinal tract but also causes skeletal complications. Arthritis and ankylosing spondylitis are among the best known of these, while periostal new bone formation in patients with Crohn's disease is rare. A report is presented on a patient who developed this complication after Crohn's disease of many year's standing.

Adult↗

[Hairy-cell leukemia with osteolytic bone changes].

Spontaneous bone fractures and/or focal osteolytic lesions were observed in three patients with morphologically and cytochemically confirmed hairy-cell leukemia 1-3 years after diagnosis and splenectomy. In a bone biopsy obtained from the body of the 12th thoracic vertebra light microscopy revealed a medullary osteopathy, the marrow cavities being infiltrated by a uniform population of rounded or slightly elongated cells. In addition, focal osteolytic lesions were observed on the trabeculae. Ultrastructurally, the cellular infiltrates consisted of reticulum cells, few mature and immature plasmocytes and numerous typical hairy cells with or without ribosome-lamella complexes. These observations demonstrate that hairy-cell leukemia may be associated with severe bone lesions similar to those observed in plasmocytoma. Moreover, these findings support the hypothesis that the hairy cell is a leukemic cell with B-lymphocyte properties.

Adult↗

[The APUD cells].

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Catecholamines↗

Arteriographic findings in hyperergic granulomatosis and vasculitis of a kidney.

A case with a probable diagnosis of a limited form of Wegener's granulomatosis is presented. Arteriography of an involved kidney revealed arterial occlusions and stenoses with infarcted parenchymal regions and a distinct collateral circulation. Compared to the renal changes in other collagenous diseases, the renovasographic findings in this case were more prominent, more centrally located, and of segmental distribution.

Adult↗

[Study of a large family with hereditary angioneurotic edema].

A large kindred (156 members) with hereditary angioneurotic edema is reported. 44 members of the family exhibit typical symptoms of the disease: recurring edemas of the skin and episodes of abdominal pain accompanied by vomiting due to mucosal edema in the stomach and intestine. In 32 patients complement studies were performed which in 28 cases revealed decreased levels of C1-inhibitor and almost normal values for C3 concentration. Among 21 members of the family who had never had symptoms of the disease, 7 also had low levels of C1-inhibitor. In 6 of 16 women, attacks often occur in conjunction with menstruation. In 9 of 10 women the symptoms of the disease had worsened during their first pregnancy. 8 patients have been successfully treated with tranexamic acid for 7-20 months.

Adolescent↗