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Biomedical subjects

R Stiens

Publications and source records attributed to R Stiens.

35 records · Page 2Linked to original sources
PubMed1980

Lung function studies in a patient with diffuse pulmonary fibroleiomyomas.

Diffuse pulmonary fibroleiomyomas were detected by open-lung biopsy in a 33-year-old male patient. Lung function studies revealed severe airflow obstruction, hyperinflation, grossly impaired single-breath-diffusing capacity and a decrease in PaO2 during exercise, i.e. data which are compatible with pulmonary emphysema. However, static lung compliance was within normal limits excluding the existence of pure emphysema. Additional special lung function tests confirmed the assumption that in diffuse fibroleiomyomas of the lung, functional patterns characteristic of obstructive and restrictive lung disease are present that are in agreement with the histological features of this disease.

Adult↗
PubMed1980

[Quantitative determination of the disintegration of nerve cells in the cortex caused by viral encephalitis (17 D-yellow fever), as a basis for the evaluation of the pathological processes in the central nerve system (author's transl)].

A loss of nerve cells in the cortex after encephalitis was reported already in the classical work by Nissl, Spielmeyer, and Spatz. A loss of nerve cells will become only noticeable if it amounts to at least 50%. But as such clear pictures are rarely found, estimations were always considered as doubtful and incorrect. Not only the number of cells is important in consideration of the morphological change in the cortex but also the size of cells. The development of a new apparatus made is possible to consider two structural parameters: the surface and the perimeter of cells. In 497 histological serial preparations obtained from 43 mouse brains we determined the number, the surface, and the perimeter of nerve cells. 39 animals were infected intracerebraly with yellow fever 17 D; 4 normal animals served as controls. Among the infected animals, 8 were treated with a mucopolysaccharide. The cells were counted within a determined area (standard unity); this area was taken from the angle between the curbura exterior and the sulcus anterior-posterior of the brain. There was a significant difference between the number of nerve cells in normal (278) and in infected (202) animals. The animals treated with mucopolysaccharide showed a normal quantity of nerve cells but surface and perimeter corresponded to the data of the infected ones. The surface of normal animals was at 23.39, that of infected at 14.29. There was also a significant difference with regard to the cell perimeter: normal 14.97, infected 12.02. This means a shrinking of cells. The cell shrinkage revealed that the nerve cells were affected. The measurement of these three parameters presents new and exact statistical findings which enable a reconsideration of neurovirulence.

Animals↗
PubMed1980

[Pathology of liver lesions in malignant non-Hodgkin lymphomas (author's transl)].

The Kiel classification of lymphomas based on cytological criteria can be applied to tumor cell types found in liver infiltrates as well. Lymphomas with low degree of malignancy are delineated distinctly against the normal parenchyma; the borderline is slightly blurred only in the centroblastic-centrocytic subtype. Generally, the portal fields in these cases are round-shaped, expanded, and filled with lymphoid cells. Lymphomas with a high degree of malignancy are characterized on the contrary by portal fields with very irregular borderlines; in some cases there is a certain similarity to piece meal necrosis. There is an increased incidence of mitoses in the malignant tissue. Bile ducts are often disrupted. Hair cell leukemia can be differentiated in paraffin sections too, if tartrate-resistent acid phosphotase is present.

Acid Phosphatase↗
PubMed1979

Quantitative determination of the disintegration of nerve cells in the cortex caused by viral encephalitis (17 D-yellow fever) (Preliminary communication).

The counting of nerve cells give an answer to the question whether there is a significant loss of cells in the cortex in the course of viral encephalitis. For normal animals, average cell numbers of 275.42 were counted; for infected animals divided into two groups depending on the severity of illness, 144.95 and 192.87 cells, respectively (p = 0.0001).

Animals↗
PubMed1978

[Behçet's disease and the gastrointestinal tract (author's transl)].

Behçet's disease is characterized by the triad of aphteous stomatitis, genital ulcerations and uveitis. This syndrome is thought to be a systemic disease with various unspecific manifestations, which may arise in other organs as well in a considerable number of cases. More than 50% of all patients do have gastrointestinal symptoms; erosive and ulcerative lesions are found primarily in the jejunum and colon. Case reports are given of 3 patients with Behçet's disease and gastrointestinal involvement; one of these patients died. All patients did have unspecific changes of esophageal motility.

Adrenal Cortex Hormones↗
PubMed1977

[Concomitant infarction of the right ventricle in patients with acute transmural myocardial infarction (author's transl)].

In 56 patients with acute transmural myocardial infarction hemodynamic parameters were studied. 21 patients proved to suffer from anterior infarction and 35 patients an inferior infarction. By clinical as well as by hemodynamic findings 10 patients out of the group of the 35 patients with inferior infarction were suspect of having a concomitant infarction of the right ventricle. As it is known from literature and documented by the present results this is not a rarity. Failure of the right ventricle is the main cause of death in these patients.

Acute Disease↗
PubMed1977

Cell-kinetical analyses of squamous cell carcinomas of the oral region and the effect of a combined therapy of 5 fluorouracil and irradiation. A contribution to the discussion about tumorcell-synchronization.

Out of 180 incubations of human biopsies 33 were from patients with malignant tumors of the oral region. In 9 cases it was possible to analyse the cell cycle of the tumor cells with the double labeling in vitro method (3H and 14C-thymidine). Histologically the tumors were keratinizing squamous cell carcinomas with high labeling indices. The generation time of the tumor cells ranged from 20 to 130 hours. The length of the DNA synthesis phase varied between 7.3 and 17.9 hours. With the knowledge of the cell-kinetic data the patients received an infusion of 5 Fluorouracil throughout the length or parts of the calculated G 1 phase. At the end of the 5 FU infusion there was a constant two-hour pause and after the duration of the calculated DNA synthesis phase the tumors were irradiated with 150 rd per session. The treatment was repeated until a total dose of 6000 rd was achieved. Under the combined therapy of 5 FU and irradiation the inoperable keratinizing highly differentiated squamous cell carcinomas regressed extraordinarily fast. The patients were free of pain after a very short time. No vital tumor tissue was visible in control biopsies. Some patients remained without any tumor recurrence now more than 2 years after onset of therapy. In the discussion it is stressed that the reason for the successful treatment of highly differentiated squamous cell carcinomas with 5 Fluorouracil and subsequent irradiation is not easily explained, because recent experimental findings and impulsecytophotometrical studies on human biopsy material suggest that both the synergistic action of thecytostatic drug and the irradiation as well as an altered recruitment of the tumor cells are responsible for the clinical success rather than a synchronisation effect.

Adult↗
PubMed1976

Detection of IgG antibodies against pigeon intestinal mucosa antigens in pigeon breeders' sera using the immunofluorescent technique.

The serum of 102 pigeon breeders was examined for circulating IgG antibodies against antigens localized in pigeon intestine by the indirect immunofluorescent technique. 15 symptomatic breeders with a positive response to inhalation challenge had antibodies against mucosa tissue. The majority of asymptomatic breeders demonstrated either a fluorescence of intestinal excrements combined with a weak fluorescence of mucosa tissue or had no detectable antibodies in their serum. By the indirect immunofluorescence, antibodies were found more frequently than by immunoprecipitin reactions in agar.

Absorption↗
PubMed1975

The cell proliferation of epithelial metaplasia in the prostate gland. An autoradiographic in vitro study.

In 147 autoradiographically examined prostate biopsy cylinders 5.4% squamous metaplasia and 6.0% transitional metaplasia were diagnosed. The average labeling index of squamous metaplasia was 4.3% and corresponded with values from non-keratinizing squamous epithelium in other locations. The labeling index of the transitional cell metaplasia was, in contrary, almost 10 times lower with an average value of 0.29% and corresponded with the values well known for the urothelium of the urinary bladder. Higher labeling indices were observed in 2 cases but these had chronic prostatitis. The autoradiographic results are in good agreement with the ultrastructural findings in which the metaplastic squamous epithelium corresponds with normal squamous epithelium by which the cellular proliferation takes place only in the stratum basale. On the other hand, transitional metaplasia exhibits DNA-synthesizing cells in the superficial cell layers just like in the urothelium.

Autoradiography↗