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Biomedical subjects

R Stark

Publications and source records attributed to R Stark.

At least 109 records · Page 6Linked to original sources
PubMed1977

Detection and molecular characterization of the thymus-brain antigen in human brain.

Anti-human brain sera were found to contain antibodies reacting with determinants present on murine thymocyte plasma membranes. This determinant is borne by the thymocyte-brain antigen of mouse thymocytes. The non species-specific determinant of the thymocyte-brain system is detectable on the thymocyte-brain antigen of human and mouse brain in comparable amounts. In contrast to these findings, the allogenic Thy-1 and the species-specific determinant of this system were only found on the thymocyte-brain antigen of mouse brain but not on the corresponding antigen of human brain. The molecular weight, Stokes radius and diffusion coefficient of the thymocyte-brain antigen of human and mouse brain are in good accordance with the data estimated for the corresponding antigen of murine thymocytes.

Animals↗
PubMed1976

[Enuresis].

Explore the source record for details and available documents.

Child↗
PubMed1976

Solubilization and molecular characterization of membrane-bound antigens shared by thymocytes and brain.

In order to characterize chemically the serologically well-defined antigens shared by thymocytes and nervous tissue of mice and rats, different solubilization procedures have been tested. Treatment of thymocyte membranes with urea-Nonidet-P40 (NP40) proved to be the most valuable method, since nearly 100% of the antigen was solubilized essentially without loss of the antigenicity. By gel filtration in urea-NP40 the molecular weight was estimated to be 35 000 and the Stokes radius in sodium deoxycholate 31.8 A. In gel filtration studies a homogenous peak was obtained, whereas isoelectric focusing yielded two peaks (isoelectric points pH 4.5-5.0 and pH 5.4). The three determinants of this antigenic system were inseparable in gel filtration and isoelectric focusing, supporting the view put forward on the basis of serological studies that they are part of the same molecule. Extraction of murine thymocyte membranes with organic solvents yielded a considerable loss of activity of the thymocyte-brain antigen. There was some residual activity in the protein fraction, but none in the organic phase. Correspondingly, the highly purified ganglioside G Gtet 2b proved unable to absorb any rabbit anti-CBA brain serum. The reduced antigenic activity of the delipidated protein fraction could be restored by addition of lipids, as well as the nonionic detergent NP40. These observations suggest that interaction of protein and lipid is necessary for the antigenicity of the thymocyte-brain antigen.

Animals↗
PubMed1976

[Hemothorax--a life-threatening complications of spontaneous pneumothorax (author's transl)].

A 23-year old male with an spontaneous hemopneumothorax and in the state of severe shock was admitted to our hospital. The etiology, incidence and therapeutic measures are discussed. It is recommended that patients with spontaneous hemopneumothorax after securing the diagnosis by radiography and puncture biopsy have to be admitted immediately in a thoracic surgery clinic. An early thoracotomy is favourable.

Adult↗
PubMed1975

[Vesicorenal reflux. Morphological diagnosis and indications for anti-reflux plasty].

The importance of reflux-pyelonephritis in children and adults is discussed. Important leading-symptoms are the incontinence after the age of four besides the cystoureteritis, which is resistant to all kinds of therapy. Following the discussion of the etiopathogenesis of the reflux and its consequences, the symptomatic of the reflux is described in detail and a diagnostic program is given. Extended urological diagnosis includes intravenous urography with preceeding x-ray-examination, reflux cystogram and cystourethrogram during urination. An essential emprovement of these diagnostic measures for the recording of the vesicoureteral reflux is the recording by the 100-mm-cutfilm-camera. Indications for surgical measures and the operative proceeding are discussed.

Humans↗
PubMed1975

[Infusion therapy in uretero-enterostomy].

The special problems of the uretero-enterostomy, which is often followed by disturbances of the electrolyte metabolism such as hyperchloremia, metabolic acidosis and hypokalemia with all complications, are dealt with. The pre-operative treatment of the patient and the postoperative infusion therapy are discussed in detail, suggestions as to the infusion, electrolyte and calorie quantity to be administered are made. The postoperative complications are demonstrated on the basis of a special case, the theories on the causes of the electrolyte imbalances are also mentioned.

Acid-Base Equilibrium↗