Biomedical subjects

R Spires

Publications and source records attributed to R Spires.

20 records · Page 2Linked to original sources

PubMedDate not supplied

Ocular manifestations in bone marrow transplantation.

1. Primary and relapsed acute leukemia is increasingly being treated by bone marrow transplantation. Graft-versus-host disease (GVHD) is a major complication of bone marrow transplantation, occurring in 50% to 70% of cases. 2. Ocular complications of bone marrow transplantation are divided in those involving either the anterior or posterior segment. Because of associated total body irradiation with different forms of chemotherapy, these patients should be routinely watched by an ophthalmologist. 3. There is a high incidence of dry eye syndrome, viral keratitis, and trophic disturbances of the cornea. The presence of GVHD increases ocular involvement and its severity. 4. A study by Lopez and colleagues indicated that 62% of patients who survived at least 6 months after bone marrow transplantation for acute leukemia developed occlusive microvascular retinopathy.

Bone Marrow Transplantation↗

PubMedDate not supplied

Central retinal vein occlusion.

1. CRVO (central retinal vein occlusion) is of two types: ischemic (hemorrhagic retinopathy) and nonischemic (venous stasis retinopathy). 2. Retinal capillary obliteration is a hallmark of retinal ischemia. Fluorescein fundus angiography gives the most valuable information in the differentiation of CRVO into it two types. The ischemic type is in sharp contrast to the nonischemic because there is significant retinal capillary obliteration in ischemic CRVO. 3. The relative afferent pupillary defect (RAPD) is very helpful in separating the ischemic type from the nonischemic type, during both the early and the late stages of the disease. There is a positive RAPD in hemorrhagic retinopathy. 4. The most serious complication of CRVO is the development of various types of ocular neovascularization.

Adult↗