Search PubMed⌕ Search

Biomedical subjects

R Sood

Publications and source records attributed to R Sood.

104 records · Page 6Linked to original sources
PubMed1981

Changes in composition and enzyme activities of mitochondrial and post-mitochondrial fractions of tissues of rats given mustard oil diet with carnitine and/or fish oil.

The effects of short-term feeding of a 20% mustard oil (containing 47% erucic acid) diet with 0.1% carnitine and/or fish oil on the activity of enzymes of lipid metabolism in mitochondrial and post-mitochondrial fractions of heart, liver, and skeletal muscles of rats were determined to study the reversal of erucic acid-induced lipidosis. Histopathological changes were also studied. The inclusion of fish oil or fish oil plus carnitine in a mustard oil diet, especially the latter, eliminated the histopathologically detectable lipidosis in heart and skeletal muscles. The reason for this appears to be the increased activity of lipase and phospholipase in tissue homogenates and of cholesterol ester hydrolase in the post-mitochondrial fraction; and also an increase in mitochondrial succinate dehydrogenase which may increase the utilization of the liberated fatty acids. The results suggest that the erucic acid-induced lipidosis is prevented or eliminated by increased lipolysis and oxidation of fatty acids when such a diet is supplemented with carnitine and/or fish oil.

Animals↗
PubMedDate not supplied

Multiple organ dysfunction syndrome.

The simultaneous dysfunction of several organs represents a challenging task for the intensivist. Systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) are expressions of an inappropriate generalized inflammatory response of the host to a variety of infectious or non-infectious stimuli. In recent years, MODS is being encountered frequently in critically ill patients due to several causes. Experimental and clinical evidence suggests that the gut, endothelium and immune system interact to produce altered metabolic and cardiorespiratory patterns. It is thus possible that a target-oriented approach, including correction of intestinal hypoperfusion, supply of specific nutrients and downregulation of the inflammatory cascade, can act as either a preventive measure for subjects as risk or as the treatment for patients with full-blown MODS.

Bacterial Infections↗