[Pulmonary tuberculosis suspected of lung cancer: a clinical study on seven operated cases (author's transl)].
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Biomedical subjects
Publications and source records attributed to R Soejima.
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The serum concentration of dibekacin (DKB) were determined in 4 healthy adult volunteers after intramuscular injection, intravenous injection and 1-hour or 2-hour intravenous drip infusion of 100 mg of DKB, and 1-hour drip infusion of 50 mg. The mean peak concentration after the 2-hour drip infusion of 100 mg of DKB was a rather low level. While the 1-hour drip infusion of 50 mg of DKB produced a peak concentration of 7.9 micrograms/ml, which is comparable to that after intramuscular injection of 100 mg. In the cases of the 1-hour drip infusion of 100 mg, the peak serum level reached 13.3 micrograms/ml, which is a relatively higher level than that after intramuscular injection of the same dose. Based on the above findings, it is suggested that the 1-hour intravenous drip infusion of DKB in doses of 50 mg to 100 mg be practically applied for therapeutic use.
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We report the case of a woman with a squamous carcinoma of the bronchus which secreted human chorionic gonadotrophin. Earlier reports have all involved males. Some evidence that estimation of serum HCG levels might prove a useful marker of early malignancy is presented.
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