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Biomedical subjects

R Smith

Publications and source records attributed to R Smith.

At least 1,369 records · Page 76Linked to original sources
PubMed1982

Conservation of protein coding potential in the long terminal repeats of exogenous and endogenous mouse mammary tumor viruses.

In vitro protein synthesis and DNA sequence analysis indicate that mouse mammary tumor virus differs from other well-characterized retroviruses in that the long terminal repeat region of the provirus has the capacity to encode proteins. Different exogenously transmitted mouse mammary tumor virus strains and endogenous proviral units conserved this open reading frame feature in the long terminal repeat despite a variation in nucleotide sequence. The proteins encoded by the different long terminal repeats were clearly related, but showed minor variations in size and tryptic peptide maps. In each case, the largest in vitro product had a molecular weight of about 36,000 to 37,000, suggesting that the open reading frame sequences must extend for approximately 1,000 nucleotides beginning at the extreme 5' end of the long terminal repeat. The fact that the reading frame was conserved among these viruses argues in favor of an in vivo function for the open reading frame protein.

DNA, Recombinant↗
PubMed1982

The cervical spine in fibrodysplasia ossificans progressiva.

Radiographs of the cervical spine in 11 patients with fibrodysplasia ossificans progressiva (FOP) have been examined, and abnormalities found in all. In 4, small cervical vertebral bodies with enlarged pedicles were seen in early childhood; later, variable fusion of the vertebrae was apparent in all patients. This fusion was first noted between adjacent neural arches in late childhood but also involved the vertebral bodies in some adult patients. It was only sometimes associated with ossification of the adjacent neck muscles, and appeared to be an important cause of neck stiffness in FOP. The radiological changes may be confused with those of Still's disease or of the Klippel-Feil syndrome.

Adolescent↗
PubMed1982

Colonic lymphoma producing alpha-chain disease protein.

Alpha-chain disease with involvement of small intestine-resulting in characteristic villus atrophy and malabsorption has not been reported in this country. We studied a 57-yr-old male who presented with a polypoid tumor of the hepatic flexure of the colon. There was no evidence of malabsorption as manifested by a normal fat balance, serum carotene, and D-xylose absorption studies and the small bowel biopsy did not show villus atrophy. The tumor in the colon was surgically removed and diagnosed as a malignant lymphoma of lymphocytic type. Tumor tissue infiltrated in the mesentery could not be excised. Alpha-chain disease protein was demonstrated in serum and urine, and also in tumor tissue by immunoperoxidase techniques. The alpha-chain disease protein was further purified and classified as subclass 1. The patient had a good clinical response to cyclophosphamide and prednisone, but still has intraabdominal lymphoma with gastric involvement, and his serum alpha-chain protein persists. This case report may represent a distinct variant of alpha-chain disease.

Colonic Neoplasms↗
PubMed1982

Adaptive behavior scale differences in scores of mentally retarded individuals referred for institutionalization and those never referred.

Adaptive Behavior Scale profiles of 68 mentally retarded individuals referred for institutionalization were compared with a matched sample of retarded individuals who were never referred for institutionalization. A discriminant analysis identified the following six domains that, in combination, accounted for the significant differences between groups: Violent and Destructive Behavior, Sexual Aberrations, Hyperactivity, Antisocial Behavior, Physical Development, and Socialization. Implications for the effectiveness of an abbreviated ABS measure for diagnostic purposes and program planning in community and institutional settings were discussed.

Adaptation, Psychological↗
PubMed1982

Retained placentas in a colony of mice.

Twenty mice were killed 1-6 days after parturition, and the uterine contents were examined grossly and microscopically. Uteri of 10 animals had retained one or more placentas, each of which was firmly attached to the uterus and usually exhibited fetal membranes and an umbilical cord. Histologic preparations revealed that the fetal blood channels in the labyrinth region were collapsed and fibrosed while some maternal blood channels were open and contained blood cells. In the junctional zone and decidua, necrosis and leukocytic invasion were evident. In median sections, a stalk of fibrous tissue extended from the uterus to the placenta.

Animals↗
PubMed1982

Immunological and physiological responses to whole-body hyperthermia.

Current information on the effect of systemic hyperthermia on the host-tumor immunologic response was reviewed. Changes in physiology caused by whole-body heat are described in a review of current studies at the National Cancer Institute and others, with particular regard to cardiovascular, endocrine, and nervous system changes with heat. The importance of these heat-affected alterations of physiology and immunology on chemotherapy and radiotherapy administration is discussed.

Animals↗