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Biomedical subjects

R Smith

Publications and source records attributed to R Smith.

At least 1,207 records · Page 67Linked to original sources
PubMed1985

Effect of liver and renal dysfunction on circulating methionine-enkephalin immunoreactivity.

Plasma methionine-enkephalin (Met-Enk) immunoreactivity has been determined in 24 patients with varying degrees of renal impairment and 14 patients with hepatic failure. Plasma Met-Enk immunoreactivity correlated inversely with creatinine clearance (r = -0.71, P less than 0.001) but was not affected by even severe hepatic failure in the absence of renal impairment. In two patients, with renal failure and elevated plasma prolactin, administration of naloxone (16 mg) had no effect on circulating prolactin concentrations. These studies indicate that the kidney has a major role in Met-Enk metabolism while the liver does not, and further suggest that elevated circulating endogenous opiates are not responsible for the increased production of prolactin found in renal failure.

Enkephalin, Methionine↗
PubMed1985

Osteoporosis of pregnancy.

Eight women with pregnancy-associated osteoporosis were studied for up to ten years. Back pain and vertebral collapse usually occurred in the first pregnancy and did not recur in two subsequent pregnancies. Except in one patient, bone histology showed no increase in resorption. Plasma concentrations of 1,25-dihydroxyvitamin D tended to be low whereas those of calcitonin were, with one exception, normal. It is suggested that in these patients there may have been a transient failure of the usual changes in calciotropic hormones to prepare the maternal skeleton for the stress of childbirth. However, subsequent pregnancies in such patients are not necessarily contraindicated.

Adult↗
PubMed1985

Soft tissue sarcomas of the hand and foot.

A retrospective study was made of 82 soft tissue sarcomas of the hand and foot. Prognosis was related to histopathologic grade of malignancy and success or failure of local tumor control. After treatment with curative intent, low-grade tumors gave a 5-year survival rate of 90%, compared to 63% for high-grade tumors. Simple excision or limited amputation of the digit, hand, or foot yielded a 5-year survival rate of 68% (15/22) and a local recurrence rate of 32%. Amputation below the elbow or knee or higher resulted in a similar survival of 68% (19/28) but no local recurrences. All patients who developed local recurrences died, except for two with low-grade tumors and one patient lost to follow-up. These observations indicate the need for systemic chemotherapy to prevent death from metastasis, and for effective local tumor control. Conventional radiation therapy may be difficult to apply at these sites. Innovative local treatment approaches to preserve limb function without jeopardizing tumor control merit study.

Adolescent↗
PubMed1985

Pressure-induced dissociation of aggregates of myelin proteolipid protein.

Sedimentation velocity and equilibrium experiments have revealed an extremely pressure-sensitive aggregation of myelin proteolipid protein in the presence of Triton X-100, dissociation of the protein aggregate being observed at pressures that are several orders of magnitude lower than those effecting disaggregation of many other proteins. These results highlight the need to employ a range of angular velocities in sedimentation studies of intrinsic membrane protein.

Animals↗