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Biomedical subjects

R Slater

Publications and source records attributed to R Slater.

100 records · Page 6Linked to original sources
PubMed1976

Transfusion therapy for cerebrovascular abnormalities in sickle cell disease.

Cerebral angiograms were performed in patients with sickle cell disease and symptoms of stroke to evaluate transfusion therapy for cerebrovascular accidents. Three patients who were transfused repeatedly for one year to maintain less than 30% hemoglobin S were compared to two patients who were not transfused. All patients had abnormal angiograms initially. After one year the angiographic abnormalities resolved in two and improved in one transfused child. The two children who were not transfused showed progressive vascular disease. For all arteriograms, the patients were prepared by transfusion with normal red cells and careful hydration.

Anemia, Sickle Cell↗
PubMedDate not supplied

Diaschisis with cerebral infarction.

Fifteen patients admitted to Philadelphia General Hospital with acute strokes had repeated measurements of cerebral blood flow measured by the 133Xenon inhalation method. A progressive decline in cerebral blood flow in both hemispheres was observed during the first week after infarction in twelve of these patients. This decline could be partially explained by loss of autoregulation, but could not be correlated with level of consciousness, clinical status of PCO2. This progressive decline in flow in the non-ischemic hemisphere indicates a process more complex than a simple destruction of axonal afferants to neurons as implied by the term diaschisis. The flow changes in the non-ischemic hemisphere are likely caused by a combination of the immediate effects of decreased neuronal stimulation modified by loss of autoregulation, release of vasoactive substances, cerebral edema, and other factors.

Aged↗
PubMedDate not supplied

Physically disabled and frail elderly: assessing their external environments.

The study reported here forms part of a 2-year government-funded research project concerned with the mobility problems of physically disabled, blind and frail elderly in their external environment. The research grew out of a set of ideas, formulated by Central Government in Wales, which suggested that the Principality has a higher proportion of disabled people than England, Scotland or Northern Ireland, and that of the particularly extreme nature of the Welsh terrain probably presented serious difficulties to these categories of people as they attempted to move around in their external environments. Although difficulties experienced by respondents in this study can be partly attributed to their physical disabilities even elderly people, who were reasonably able-bodied, reported problems in moving around in their local areas. Some of the barriers to mobility, described in this project, are a function of existing legislation not being enforced, while others require new legislation to be enacted.

Activities of Daily Living↗