Search PubMed⌕ Search

Biomedical subjects

R Skowsky

Publications and source records attributed to R Skowsky.

9 recordsLinked to original sources
PubMed1985

Hormonal control in a state of decreased activation: potentiation of arginine vasopressin secretion.

Behaviorally induced stress is associated with increased arginine vasopressin (AVP) secretion. In this report we describe a phasic conditioned response of AVP secretion yielding 2.6-7.1 times normal plasma concentration of this hormone in association with a physiological state of decreased activation, that associated with the mental technique of "transcendental meditation" (TM) in long-term practitioners (6-8 years of regular elicitation). Such a very large phasic response of AVP was previously unknown in the normal physiology of AVP. This elevation was not accompanied by elevation of plasma osmolality. Unstylized ordinary eyes closed rest in a separate group of subjects studied in the same manner was associated with normal plasma AVP concentration. Galvanic skin resistance (GSR) increased during both TM and rest with significantly larger increase associated with TM. Other measures of activation, including muscle metabolism, and the Spielberger Anxiety Inventory indicated marked relaxation in association with TM. In previous research it has been shown that blood pressure does not change acutely during this behavior. These observations indicate that neither stress nor operation of other usual homeostatic control mechanisms are responsible for elevated for AVP in the meditators. It is speculated that the apparently unique mechanism of TM-induced AVP secretion may be more specifically related to the behavioral effects of meditation.

Adult↗
PubMed1984

Correlating thyroid and parathyroid function with age.

A double dilemma faces the clinician who suspects thyroid disease in the elderly--both lab tests and treatment protocol were developed using younger patients. Reviewing the literature and their own recent data, the authors suggest how to evaluate thyroid-related lab data, taking age into account.

Aged↗
PubMed1980

Antidiuretic hormone in end-stage renal disease.

Quantative data on plasma levels of antidiuretic hormone (ADH) in renal failure are limited. We measured predialysis plasma ADH levels using a double antibody radioimmunoassay in 14 patients with end-stage renal failure. Plasma ADH was inappropriately elevated in the majority of tested patients despite normal plasma osmolality, moderately elevated blood pressure, and hypervolemia. The etiology of increased plasma ADH in our population is unclear.

Adult↗
PubMed1980

Hemodialysis studies of antidiuretic hormone.

Hemodialyzability of antidiuretic hormone (ADH) was studied in 14 patients undergoing hemodialysis procedure. In addition hemofiltration (dry dialysis) was performed in 8 patients and hemofiltrate samples were collected for ADH assay. The mean values for plasma ADH level in ingoing and outgoing blood were nearly identical. Moreover, no ADH was detectable in the hemofiltrate samples. These findings suggest lack of significant ADH removal by dialysis or hemofiltration.

Adult↗
PubMed1980

Effect of isoosmolar volume reduction during hemofiltration on plasma antidiuretic hormone in patients with chronic renal failure.

The effect of isoosmolar volume reduction on plasma ADH level was studied in 8 patients with chronic renal failure utilizing hemofiltration technique. Plasma ADH fell significantly (P less than 0.001) after one hour of hemofiltration despite volume reduction which was expected to elevate the ADH level. After two hours of hemofiltration, ADH remained low in 5 patients and increased in 3. Post-hemofiltration mean blood pressure was generally lower in patients whose ADH rose than those whose ADH remained low. The two groups were otherwise comparable with respect to total fluid loss, hemofiltration rate, and fluid removed expressed as percent body weight. It can thus be suggested that in these patients a rise in plasma ADH in response to fluid reduction may require a fall in the arterial blood pressure below a critical level. While the rise in plasma ADH observed with continued fluid removal in some patients can be readily explained, we have no clear explanation for the paradoxical initial fall of ADH in all patients and subsequent maintenance of low levels observed in the majority of patients. This unusual ADH response to isoosmolar volume reduction may represent some unidentified mechanism of ADH regulation in patients with end-stage renal disease.

Adult↗
PubMed1979

Lack of adrenal androgen stimulation by ACTH in extreme hyperprolactinemia.

Acute and prolonged alpha 1-24 corticotropin stimulation was performed on a treated chromophobe adenoma patient with partial ACTH deficiency and extreme hyperprolactinemia. Cortisol and aldosterone stimulated normally. However, the basal concentrations of androstenedione (A) and dehydroepiandrosterone (DHA) were low, and that of DHA-sulfate (DHAS) was undetectable. Furthermore, A and DHA did not stimulate normally, and DHAS did not stimulate at all. It has been claimed that adrenal androgen production is increased in hyperprolactinemia. However, the inability of prolactin (Prl) to maintain adrenal androgen (AA) secretion, with and without added ACTH, is demonstrated in this patient.

Adenoma, Chromophobe↗
PubMedDate not supplied

Scleredema diabeticorum: a common and distinct cutaneous manifestation of diabetes mellitus.

Scleredema diabeticorum is characterized by a dramatic increase in the thickness of the skin of the posterior neck and upper back. Of the 17 scleredema patients diagnosed by us in the last 15 yr, 16 have had type II diabetes mellitus. In a prospective study of 484 diabetic outpatients we found the prevalence of scleredema to be 2.5%. Angina pectoris was the only complication that occurred significantly more frequently in scleredematous diabetic patients than in a control group of diabetic patients without scleredema. Scleredema diabeticorum is a distinct cutaneous condition peculiar to diabetic individuals and ought not to be confused with scleredema of Buschke or scleroderma.

Back↗