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Biomedical subjects

R Siegberg

Publications and source records attributed to R Siegberg.

29 records · Page 2Linked to original sources
PubMed1987

Serum sex hormone concentrations in adolescent secondary amenorrhoea.

The hormone concentrations of 17 amenorrhoeic adolescent girls, with no apparent environmental factor associated with the secondary amenorrhoea, were evaluated. 28 regularly menstruating adolescent girls served as controls. The clinical characteristics of both groups were similar, except that the amenorrhoeic girls showed clinical signs of androgenicity significantly more often than the regularly menstruating group. The concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin, oestradiol, progesterone, testosterone, androstenedione, dehydroepiandrosterone (DHEA), dehydroepiandrosterone-sulfate (DHEAS), and sex hormone-binding globulin (SHBG) were determined in weekly blood specimens from the amenorrhoeic girls and during one menstrual cycle from the regularly menstruating girls. The amenorrhoeic girls had significantly higher concentrations of LH, androstenedione and free testosterone than the regularly menstruating girls. The LH/FSH ratio was significantly higher in the amenorrhoeic group than in the control group. The SHBG concentrations were significantly lower in the amenorrhoeic group than in the regularly menstruating group. Evaluation of the clinical signs of androgenicity combined with LH and androgen measurements seems important in the investigation of adolescent menstrual disorders.

Adolescent↗
PubMed1987

Serum sex hormone levels in adolescent girls with polymenorrhoea.

The hormone levels of 13 polymenorrhoeic adolescent girls were evaluated. Twenty-eight adolescent girls with regular menstruation served as controls. Serum concentrations of luteinizing hormone, follicle-stimulating hormone, prolactin, oestradiol, progesterone, testosterone, androstenedione, dehydroepiandrosterone, dehydroepiandrosterone-sulphate, and sex hormone binding-globulin were determined in blood samples obtained over one menstrual cycle. In girls with polymenorrhoea the frequency of ovulation was significantly lower than in the control group as estimated on the basis of the progesterone level five days before the onset of menstruation. Low progesterone and oestradiol levels during the late part of the cycle were the main abnormalities of polymenorrhoeic adolescent girls. No differences in the other hormonal parameters were found. The duration of menstrual bleeding was similar in both groups.

Adolescent↗
PubMed1986

Immunological disturbances in patients with premature ovarian failure.

Eighteen patients with postmenopausal gonadotrophin levels and secondary amenorrhoea before the age of 35 years (premature ovarian failure, POF) were examined for the presence of cellular and humoral immune defects. Six patients had an abnormally low natural killer (NK) cell activity. The levels of circulating immune complexes were increased in six patients. Tissue antibodies were detected in six patients and two of these possessed ovarian antibodies. Leukocyte migration inhibition in the presence of ovarian antigen was slightly enhanced in three patients. Altogether 12 patients (66%) with POF had some immunological defect or defects suggesting that immune mechanisms are often involved in the aetiology of POF.

Adult↗
PubMed1986

Endocrinologic features of oligomenorrheic adolescent girls.

The plasma concentrations of sex hormones were measured in 45 oligomenorrheic and 28 regularly menstruating adolescent girls. Testosterone, androstenedione, dehydroepiandrosterone, dehydroepiandrosterone-sulfate, estradiol, progesterone, luteinizing hormone, follicle-stimulating hormone, prolactin, and sex hormone-binding globulin levels were determined in blood samples collected during one menstrual cycle. The oligomenorrheic girls had significantly higher concentrations of luteinizing hormone, androstenedione, dehydroepiandrosterone-sulfate, and free testosterone than regularly menstruating girls. Sex hormone-binding globulin concentrations were significantly lower in the oligomenorrheic group. The oligomenorrheic girls were not obese. Signs of acne or hirsutism were absent or mild. Sixty-six percent of the oligomenorrheic cycles were ovulatory. The significance of the hormonal findings is discussed.

Adolescent↗
PubMed1985

Urinary 6-keto-prostaglandin F1 alpha during ovulation induction.

To elucidate the role of the vasodilatory prostacyclin (PGI2) in human ovulation, urinary samples were collected from spontaneously ovulating women (n = 8) and from those undergoing ovulation induction with clomiphene (seven women, 9 cycles) and human gonadotropins (five women, 11 cycles). The samples were assayed for 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), a breakdown product of PGI2, employing high-pressure liquid chromatography and radioimmunoassay. The urinary 6-keto-PGF1 alpha was not consistently related to the menstrual cycle day at collection, the occurrence of spontaneous (n = 8) or induced (n = 11) ovulation, or the simultaneous concentration of estradiol in plasma. However, its concentrations both before and after the approximated time of ovulation during clomiphene (41.6 +/- 6.7 and 52.7 +/- 7.9 pmol/mmol creatinine, before/after, mean +/- standard error) or gonadotropin treatment (49.0 +/- 5.8 and 48.1 +/- 6.8 pmol/mmol creatinine) were higher (P less than 0.01) than those in spontaneously ovulating women (26.4 +/- 3.8 and 20.5 +/- 3.0 pmol/mmol creatinine, respectively). Multiple ovarian follicles, as assessed ultrasonographically, developed during four courses of the treatments with gonadotropins, and in three of them the urinary 6-keto-PGF1 alpha was high. The data suggest that treatment with clomiphene and gonadotropin is accompanied by increased production of PGI2, perhaps in the ovaries and/or in the kidneys. This may perhaps play a role in the etiopathogenesis of ovarian hyperstimulation syndrome.

6-Ketoprostaglandin F1 alpha↗
PubMed1984

Sex hormone profiles in oligomenorrheic adolescent girls and the effect of oral contraceptives.

The hormonal profiles and the effect of oral contraceptives (OCs) on 16 oligomenorrheic and 10 regularly menstruating adolescent girls were studied. Testosterone, androstenedione, dehydroepiandrosterone, estradiol, progesterone, luteinizing hormone, follicle-stimulating hormone, prolactin, and sex-hormone-binding globulin were determined on blood samples obtained during a control cycle, during OC treatment, and during the follow-up cycle after discontinuation of OC use. The oligomenorrheic girls had significantly higher concentrations of androstenedione and total and free testosterone than regularly menstruating girls during the control cycle. Sex-hormone-binding globulin concentrations were significantly lower in the oligomenorrheic group. Both in oligomenorrheic and regularly menstruating girls OC treatment caused a decrease in the mean concentrations of all hormones, except prolactin, to similar levels. For 2 to 4 weeks after treatment the oligomenorrheic girls had significantly lower levels of androstenedione, total and free testosterone, and luteinizing hormone than before treatment. In the control group there were no significant differences between pretreatment and posttreatment hormone concentrations. The risks and benefits of prescribing OCs for oligomenorrheic adolescent girls are discussed.

Adolescent↗
PubMed1983

Reduced short-term variability of fetal heart rate in association with maternal hyperglycemia during pregnancy in insulin-dependent diabetic women.

The differential index, which describes the short-term component of fetal heart rate variability, and maternal blood glucose levels were measured 109 times in 19 insulin-dependent diabetic mothers in the second half of gestation. An abnormal differential index was observed more often with maternal hyperglycemia (11/45) than with normoglycemia (5/64). A significant negative linear correlation was found between the differential index and the blood glucose level of the mother.

Blood Glucose↗
PubMedDate not supplied

Ovarian stimulation during gonadotropin treatment after hCG administration monitored by ultrasound and serum estradiol and progesterone.

Ovarian volumes, measured with ultrasound, and serum estradiol and progesterone concentrations were studied during gonadotropin treatment cycles 1 week after hCG administration in 23 patients, of whom nine had polycystic ovarian syndrome (PCO), eight oligomenorrhea or amenorrhea corresponding to WHO group II (OMG), and six hypogonadotropic amenorrhea corresponding to WHO group I (HGT). The ovarian volumes were greater in the PCO and HGT groups than in the OMG group. The serum estradiol and progesterone concentrations correlated more closely with ovarian volumes in the HGT group than in the PCO and OMG groups. The present study failed to demonstrate a lower risk of hyperstimulation in the HGT group in comparison with the PCO and OMG groups. Six patients conceived, and ovarian volumes were greater and serum progesterone concentrations higher during conceptual cycles than during nonconceptual cycles.

Adult↗