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Biomedical subjects

R Siebenmann

Publications and source records attributed to R Siebenmann.

At least 55 records · Page 3Linked to original sources
PubMed1988

Long-term outlook after atrial correction of transposition of great arteries.

Late results were reviewed in 220 survivors after atrial correction of transposition of the great arteries who were operated between 1964 and 1985. Senning's procedure and its various modifications have been used; all patients who survived 30 days after correction were included in this analysis. Average follow-up for the whole group was 10.3 years; 113 patients were observed for 10 years, 26 patients for 15 years, and 8 patients for 20 years. The actuarial survival rate for the whole group was 89% at 10 years, 87% at 15 years, 82% at 20 years. It was higher in simple than in complex transposition (92% versus 84% at 10 years). Sudden deaths (8 patients) and late heart failure (6 patients) were the principal causes of death, predominantly in the complex transposition group (10/13 deaths). Late survival was more common in the latter part of the study, with 95% of patients operated on after 1978 surviving 9 years as opposed to 84% of patients operated on earlier. Late reoperation was necessary in 18 patients (8%), with 12 reoperations occurring within 2 years after correction. Cumulative reoperation rate reached 11.7% after 10 years. Reoperations were more common in complex than in simple transposition (14% versus 6%, p less than 0.05). Late arrhythmias can occur after atrial correction, and the cumulative incidence of pacemaker implantations was 8% at 10 years. Most of the survivors are functionally free of symptoms (83% of the simple and 75% of the complex transposition group). Significant tricuspid valve incompetence was encountered in only three patients, with two valve reconstructions being possible. In summary, long-term outlook for survivors of atrial correction for transposition of the great arteries remains encouraging, although complex transposition does seem to engender more late problems. Atrial correction is still warranted in simple transposition, but close cardiological surveillance is necessary.

Actuarial Analysis↗
PubMed1979

[Salmonella colitis].

Salmonella colitis is defined on the basis of 3 case reports and 75 well-documented cases from the literature. Salmonella colitis is an acute ulcerative colitis occurring in enteric salmonellosis. There is complete clinical and endoscopic remission within 4--8 weeks and no relapse. The disease is to be distinguished from idiopathic ulcerative colitis in a salmonella carrier state. The difficulties of this differential diagnosis are demonstrated in a further case report.

Adult↗
PubMed1979

[Pathogenesis of bone marrow necrosis in a patient with cancer].

Bone marrow necrosis was observed in a 23-year-old pregnant woman with severe anemia and thrombocytopenia due to bilateral ovarian carcinoma. After removal of the primary tumors, the hematological findings returned to normal, but the progression of the metastasis lead to respiratory insufficiency and death. The possible mechanisms leading to bone marrow necrosis are discussed. In our case, it could be shown that emboli of tumor cells into the vessels of the bone marrow lead to the necrosis of the marrow. The embolization was temporarily stopped after removal of the ovaries.

Adult↗
PubMed1976

Primary Krukenberg tumour in pregnancy.

The literature on primary Krukenberg tumours in pregnancy is reviewed. 6 cases are reported and all could be accepted as complying with the international classification of primary ovarian tumours. An additional case is presented with mostly osteoplastic metastases and necrosis of the marrow.

Adenocarcinoma, Mucinous↗
PubMed1976

[Lymphangiomyomatosis. Presentation of a case and review of the literature].

Diffuse lymphangiomyomatosis is a rare disorder of the mediastinal and retroperitoneal lymph nodes due to chronic benign proliferation of the smooth muscle cells in the lymphatics. This process leads to chylothorax and chylascites and eventually to cystic lung disease. The pulmonary complications are usually result in respiratory failure and death. The disease is only observed in females. A typical lethal course in a young woman is described and the literature is reviewed. The possible etiologic and therapeutic implications are discussed.

Adult↗