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Biomedical subjects

R Shimizu

Publications and source records attributed to R Shimizu.

At least 271 records · Page 15Linked to original sources
PubMed1987

Spread of epidural analgesia following a constant pressure injection--an investigation of relationships between locus of injection, epidural pressure and spread of analgesia.

(1) The spread of epidural analgesia following injection of 15 ml of 2% mepivacaine was 17.3 +/- 0.6, 14.3 +/- 0.4, and 13.3 +/- 0.7 spinal segments in cervical, thoracic, and lumbar epidural analgesia, respectively. The patient's age showed significant correlation with the spread of epidural analgesia in cervical (r = 0.5776, p < 0.001), thoracic (r = 0.3758, p < 0.01), and lumbar area (r = 0.8195, p < 0.001). The spread of cervical epidural analgesia was more caudad than cephalad (p < 0.05), but in lumbar epidural analgesia it was more cephalad than caudad (p < 0.05). There was no difference between the cephalad and caudad spread in thoracic epidural analgesia. (2) The epidural pressure immediately after injection of 15 ml of 2% mepivacaine into the lumbar epidural space at a constant pressure (80 mmHg) correlated to the patient's age (r = -0.5714, p < 0.001) and the spread of analgesia (r = -0.3904, p < 0.05). The lower epidural pressure associated with higher age, the wider spread of analgesia. There was no significant correlation between the residual pressure at 60 seconds and the age or the spread of analgesia.

Journal Article↗
PubMed1986

[A study on the penetration of imipenem/cilastatin sodium into the female genital tissues].

A new carbapenem antibiotic, imipenem/cilastatin sodium (MK-0787/MK-0791), was administered by intravenous drip infusion at a dose level of 500 mg/500 mg to 30 patients who underwent total abdominal hysterectomy for uterine myomas with or without benign ovarian tumors. The uterine arteries were clamped bilaterally at 0.25, 0.5, 1, 2, 3, 4, 6 and 8 hours after administration, and plasma samples and uterine tissues were taken for measurements of MK-0787 by bioassay and MK-0791 by HPLC. The measured values were analyzed using a two-compartment open model. Maximum concentrations of MK-0787 at 0.5 hour after the start of intravenous drip infusion were 98.5 micrograms/ml in the antecubital vein, 100.1 micrograms/ml in the uterine artery, 26.5 micrograms/g in the oviduct, 21.2 micrograms/g in the ovary, 19.1 micrograms/g in the endometrium, 19.0 micrograms/g in the myometrium, 22.1 micrograms/g in the cervix uteri and 16.4 micrograms/g in the portio vaginalis. These results suggest that the penetration of MK-0787/MK-0791 into female genital tissues is good, and sufficient concentrations are obtained enough to inhibit organisms which are frequently isolated from patients with pelvic inflammatory disease.

Adnexa Uteri↗
PubMed1986

[A case of ulcerative colitis relapsing at the defunctionalized colon after subtotal colectomy].

A 25-year-old female with left sided ulcerative colitis underwent subtotal colectomy, and colo-anal anastomosis with diverting ileostomy by combined abdomino-sacral approach on February 14, 1985. Immediately after the operation, bleeding from the anus occurred, and one month after the operation, endoscopic examination revealed the relapse of the ulcerative colitis in the remaining colon. It was recognized, that relapse had occurred postoperatively at the nonfunctioning colon, which had been free from the disease so long as eight years since the onset of the disease. Then the relapsed colon was removed, and ileoanal anastomosis with diverting ileostomy was performed, again by combined abdomino-sacral approach. The sacral approach offered an excellent operative field and ensured the anastomosis between the small intestine and the anus.

Adult↗
PubMed1986

[An evaluation of the multidisciplinary treatment of carcinoma of the maxillary antrum in head and neck surgery].

Radiation therapy combined with surgery or regional chemotherapy was given to 114 cases of squamous cell carcinoma of the maxillary antrum from 1972 to 1983 at Gunma Cancer Center. The each treatment method was contributed to successful multidisciplinary treatment consists of partial maxillectomy, radiation therapy doses of 40 Gy and regional chemotherapy using 5 FU doses of over 2,000 mg. The 5 year cumulative survival rate was 34.7% in this study. The role of minor surgery of the antrum after radiation and chemotherapy was available for irradiated necrotizing tumor tissue, residual lesion or bone necrosis of the antrum. This additional surgery was very useful as a post radio-chemotherapeutic treatment in this study of multidisciplinary treatment.

Carcinoma, Squamous Cell↗
PubMed1985

An evaluation of neck dissection in carcinoma of the tongue.

Forty-six neck dissection cases were performed out of 117 cases of tongue cancer occurring from 1973-1981 at the Gunma Cancer Center. Among the 47 cases, 27 were initially treated surgically. In 14 cases radium therapy was used for the primary lesion and was followed by neck dissection. In another 13 cases hemiglossectomy and neck dissection were performed together. In addition, in 19 cases neck dissection was performed as secondary treatment for metastatic nodes or for recurrence of the primary lesion following radium therapy. In the cases of neck dissection performed as initial treatment along with hemiglossectomy, 84.6% had a two-year survival rate. Neck dissection performed as a secondary treatment resulted in a 46.7% survival rate over 3 years. It is evident from these figures that neck dissection performed as initial treatment results in better prognosis for the patients. In cases where metastatic nodes are present or suspected, neck dissection and hemiglossectomy should be undertaken.

Combined Modality Therapy↗
PubMed1985

[Study on transfer of aztreonam into female genital organs].

Aztreonam (AZT) is a newly developed beta-lactam antibiotic for use of intravenous injection. It is the first drug in the world of monobactam series with the structural characteristic of monocyclic beta-lactam. The antimicrobial spectrum of AZT is unique, having little or no susceptibility against Gram-positive organisms and anaerobes, but showing high susceptibility against aerobic Gram-negative rods including Pseudomonas. One gram of AZT was given intravenously to 32 patients prior to abdominal total hysterectomy for uterine myoma. Bilateral uterine arteries were clamped at 0.25, 0.5, 1, 2, 4, 8 or 12 hours after administration, and serum samples and uterine tissues were taken for the measurement of AZT concentration by bioassay method. Little difference was found in the serum concentration between cubital venous and uterine arterial serum, the half-lives of both being 2.11 hours. The initial concentrations were estimated to be 68.0 micrograms/ml and 63.9 micrograms/ml, respectively. While the peak concentrations of the portio vaginalis, cervix uteri, myometrium and oviduct were obtained at about 10 minutes, those of the endometrium and ovary were at 18.2 minutes and 31.3 minutes, respectively. They were as follows; the portio vaginalis 50.0 micrograms/g, the cervix uteri 43.6 micrograms/g, the myometrium 29.8 micrograms/g, the oviduct 44.7 micrograms/g, the endometrium 27.3 micrograms/g, the ovary 29.0 micrograms/g. After showing peak, tissue levels were kept fairly high up to 3 hours, then decreased gradually as time passed up to approximately 8 hours. Judging from its favorable transfer into the uterine tissues and MICs against main clinical isolates in the field of obstetrics and gynecology, AZT is evaluated to be clinically useful in the treatment of obstetrical and gynecological infections.

Adult↗
PubMed1985

[Study on the transfer of cefminox into female genital organs].

One gram of cefminox (CMNX, MT-141) was injected intravenously to a total of 29 patients prior to abdominal total hysterectomy and drug levels in the uterine and adnexal tissues were bioassayed. Serum samples and uterine tissues were taken at 0.25, 0.5, 1, 2, 4 or 6 hours after the administration, when bilateral uterine arteries were clamped. As to serum levels no difference has seen between cubital venous serum and uterine arterial serum, the half-lives being 2.32 hours and 2.22 hours, respectively. The peak level was 66.7 micrograms/ml for both. The drug level in tissues reached its peak at 15 minutes in the myometrium and cervix uteri, at 30 minutes in the endometrium, portio vaginalis and oviduct and at 1 hour in the ovary. The mean peak level was the highest for the oviduct (55.3 micrograms/g), followed by the portio vaginalis (47.7 micrograms/g), the cervix uteri (46.2 micrograms/g), the myometrium (42.8 micrograms/g), the ovary (37.3 micrograms/g) and the endometrium (34.2 micrograms/g) in this order. After reached the highest levels, the tissue levels decreased gradually in the same manner as the serum levels. From these results it was shown that CMNX is well transferred into various female genital tissues to achieve concentrations higher than MICs for organisms isolated clinically with high incidences in the field of gynecology and obstetrics. It was assumed from these results that CMNX is clinically useful enough in the treatment of genital organ infections.

Adult↗
PubMed1985

[An evaluation of multi-disciplinary treatment combined with intra-arterial chemotherapy of head and neck cancer].

Seventy-five cases of head and neck cancer except of maxillary sinus, 27 cases of mesopharyngeal cancer, 6 cases of oral cancer, 9 cases of thyroid cancer and 9 cases of the other cancer, were treated with this multi-disciplinary treatment and the results were evaluated in this series. An intraarterial infusion drug, 5-FU, was used mainly through the superficial temporal artery. The five year survival rate was 46.1% in mesopharyngeal cancer, 34.4% in oral cancer and 33.3% in thyroid cancer. The results were relatively satisfactory despite the advanced stage of the cancer. Intraarterial chemotherapy has been a common treatment for maxillary cancer but the indication of this treatment should be developed in advanced head and neck cancer with radiotherapy or surgical treatment as a part of multi-disciplinary treatment.

Brachytherapy↗