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Biomedical subjects

R Sergysels

Publications and source records attributed to R Sergysels.

At least 73 records · Page 4Linked to original sources

[Instrumentation support in respiratory kinesiotherapy].

The points of impact of instrumental support in respiratory physiotherapy are numerous; they concern primarily the pulmonary expansion, bronchial drainage and function of respiratory muscles. The pulmonary expansion may be helped by incitant spirometry and either intermittent or continuous positive pressure respiration, or indirectly by the utilisation of respiration against resistance (expiratory bottles, masks with uni-directional valves and expiratory resistances etc.). These different techniques may be used in the presence of instability of the respiratory units, secondary to an alteration of surfactant or to closure of the small airways induced by a transitory reduction (in the post-operative period) or permanent reduction (such as parietal wall disease of mechanical or neuro-muscular origin) of the functional residual capacity (CRF). If the continuous positive airway pressure (CPAP) seems particularly helpful for the CRF to recover to the pre-operative level it also appears on the contrary as the least efficacious technique to increase trans-pulmonary pressure. The instrumental support for bronchial drainage may theoretically affect the tension activity of the transport (instrumental help in the pulmonary expansion and in hyperventilation), muco-ciliary transport (external parietal vibration or internal vibrations applied to the upper airways), the biphasic flow (expiratory assistance by negative pressure and humidifiers). The function of the respiratory muscles may in certain cases be improved by the use of abdominal pneumatic cuirasses, by hyperventilation exercises in an isocapnoeic milieu or in breathing exercises against an additional inspiratory or expiratory resistance. If the physiological foundation of mechanical support in respiratory education may be frequently identified, the clinical results reported in the literature are often contradictory.

Drainage↗

Influence of exercise and CO2 on breathing pattern in patients with chronic obstructive lung disease (COLD).

In ten eucapnic patients with chronic obstructive lung disease (COLD) we evaluated the breathing pattern during induced progressive hypercapnia (CO2 rebreathing) and progressive exercise on an ergometric bicycle (30 W/3 min). The time and volume components of the respiratory cycle were measured breath by breath. When compared to hypercapnia, the increase in ventilation (VE) during exercise was associated with a smaller increase in tidal volume (VT) and a greater increase in respiratory frequency (fR). Plots of tidal volume (VT) against both inspiratory time (TI) and expiratory time (TE) showed a greater decrease in both TI and TE during exercise than with hypercapnia. Analysis of VE in terms of flow (VT/TI) and timing (TI/TT) showed VE to increase by a similar increase to that in VT/TI during both exercise and hypercapnia, while TI/TT did not change significantly. When the patients were matched for a given VE (28 l.min-1), exercise induced a smaller increase in VT (p less than 0.05), a greater increase in fR (p less than 0.025); TI (p less than 0.025) and TE (p less than 0.01) were found to be smaller during exercise than hypercapnia. The change in the off-switch mechanism during exercise and hypercapnia could account for our results.

Adult↗

Failure to demonstrate complement activation during bronchial challenge test.

In order to demonstrate a possible complement activation during early bronchospastic reaction in asthma, we have measured plasmatic C3d (a split product of C3) and the C3d/C3 index, both of which are sensitive indices of complement activation. Twenty-nine allergenic bronchial challenge tests were accomplished, with an absence of response in six cases, an early reaction in sixteen cases and a dual reaction in seven cases. Changes in plasmatic C3d or C3d/C3 five min after an early reaction, or five min after the last dose of allergen (in the six cases without bronchial response) were insignificant. However, complement activation in the lungs during asthmatic reaction cannot be completely excluded without studies using the bronchoalveolar technique.

Adolescent↗

[Asthma and complement].

The complement system has an important place in the development of the inflammatory reaction. The complement may be activated by the classical pathway (itself activated by immune complexes, CRP etc.) or the alternative pathway (activated by bacterial endotoxins, different lung allergens etc.). This activation culminates in the release of opsonising, chemotactic, smooth muscle constrictor, and mast cell activating factors. The complement system is present locally at the level of the bronchi and could participate in the development of bronchial inflammation narrowly associated with asthma. Study of the complement system in the plasma in asthmatics has not shown a relation between its state of activation and bronchomotor tone. However, in view of recent studies of the complement in the bronchi, analysed on broncho-alveolar lavage, the potential role of complement in asthma should be re-evaluated.

Asthma↗

Effect of inhaled histamine on occlusion pressure and breathing pattern in asthmatic patients.

In animals, histamine inhalation is known to increase either respiratory frequency or respiratory drive by stimulation of airway vagal sensitive endings. However, it is not well known whether these changes are concomitant in man. In order to elucidate this point, we carried out the present investigation in thirty-five asthmatic patients who underwent bronchial provocation test by progressively doubling the dose of inhaled histamine. Bronchial reactivity to histamine allowed two populations of patients to be defined: group I with moderate and group II with mild, increased reactivity. In the twenty-three group I patients, neuromuscular inspiratory drive, assessed by mouth occlusion pressure (P0.1), was found to be significantly increased while no significant changes in breathing pattern were noted. In the twelve group II patients histamine did not modify P0.1 or breathing pattern. However, we were able to separate in group I a sub-group of ten patients, as with atopic asthma, in which histamine-induced increase in P0.1 was paralleled by rapid and shallow breathing (RSB). Changes in P0.1 and breathing pattern did not depend on baseline airway calibre. In group I, after bronchoconstriction had been reversed by inhaling a beta 2-agonist bronchodilator agent (fenoterol), P0.1 decreased significantly and RSB was found to be reversed; however, these changes were not interrelated. We concluded that: in asthmatics, histamine-induced increase in P0.1 is not necessarily paralleled by, nor related with, change in breathing pattern and in atopics a 'sensitization' of vagal receptors could account for the concomitance of enhanced P0.1 with RSB.

Administration, Inhalation↗

Unilateral chest wall paradoxical motion mimicking a flail chest in a patient with hemilateral C7 spinal injury.

After a lower hemi-cervical spinal cord injury, a patient presented with a left hemiplegia and on the same side a unilateral chest wall paradoxical motion mimicking a flail chest. X-rays demonstrated a left hemilateral C6 injury but no rib fractures. We demonstrated that the paradoxical motion was due to the action of the diaphragm acting on the rib cage with intercostal respiratory paralysis on the side of hemiplegia.

Diagnosis, Differential↗

Functional evaluation in stage I pulmonary sarcoidosis.

A functional evaluation was performed in 9 non-smoking patients suffering from sarcoidosis characterized, on chest roentgenograms, by hilar adenopathies (stage I). Frequency dependence of compliance (5 cases) and decreased conductance of the upstream segment (3 cases) were the major findings. From this it is concluded that, even at stage I, small-airway impairment may be documented in some patients, suggesting the existence of peribronchiolar granulomatous infiltration.

Adult↗

Breathing pattern and neuromuscular drive during CO2 rebreathing in normal man and in patients with COPD.

In 11 normal subjects and in 10 patients with chronic obstructive pulmonary disease we evaluated breathing pattern and mouth occlusion pressure (PO.1), while breathing room air and during reinhalation of a hypercapnic hyperoxic gas mixture. In the breathing pattern we analyzed the time and volume components of the respiratory cycle: tidal volume (VT), inspiratory time (Ti), expiratory time (Te), total time of respiratory cycle (Ttot); mean inspiratory flow (VT/Ti) and Ti/Ttot ratios, respiratory frequency (RF) and instantaneous ventilation (VE). In the normal subjects, increase in VE during rebreathing mainly depended on an increase in both VT and VT/Ti without significant changes in Ti. During CO2 rebreathing the patients exhibited a lesser increase in VE compared to normals, due to a lesser increase in VT. However, expressing VT in percent of resting inspiratory capacity showed that VT attained at the end of rebreathing (VTmax) was similar to that noted in the normal subjects at the same minute of rebreathing. Furthermore, percent increase in VE, VT, VT/Ti and PO.1 between resting value and that at 56 mm Hg (delta %), were significant in both groups with a major increase in the normal subjects for VE and VT/Ti. In comparison, delta % decreases in both Te and Ttot were found to be significant only in the normal subjects. VT/Ti was related to VE in a similar way in the two groups. In contrast, in the normal subjects, Ti/Ttot did not increase with increasing VE. During rebreathing increase in PO.1 was found to be similar in the normal subjects and in patients. However, for a given neuromuscular drive VE and VT/Ti were greater in the normal subjects than in the patients. These data show that in the patients as a whole no significant changes in breath intervals occur during CO2 rebreathing. Furthermore, in patients, in spite of a similar increase in neuromuscular drive, the efficiency by which inspiratory muscle output (PO.1) is converted into VT/Ti was found to be reduced.

Adult↗

Complement activation in bronchial asthma evaluated by the C3d/C3 index.

In order to demonstrate a suspected complement activation in bronchial asthma, we measured the C3d (split product of C3) and the C3d/C3 ratio in 73 adults. Both are considered to be a sensitive index of complement activation. Compared with the value obtained in 47 normal subjects, the C3d level and the C3d/C3 ratio level were found significantly higher in asthmatic subjects. Fourteen asthmatics presented an increased C3d/C3 above the calculated limit of normality. These 14 subjects differed from the other asthmatics by a significantly lower C4 plasmatic level, suggesting an activation of the classical pathway of the complement system. Nevertheless, the clinical significance of these observations remains difficult to interpret in view of the absence of significant differences of clinical, allergologic and respiratory functional parameters between asthmatics with low or high C3d/C3 index.

Adolescent↗

[Interaction between asthma and maxillary sinusitis].

We have studied atopic status and respiratory function in 69 asthmatics in relation to possible radiological changes in the sinuses. These alterations were classified under four headings: normal, mucosal thickening (greater than 3 mm), polyp or opaque films. The bronchial obstruction, evaluated by FEV1/FVC ratio was compared in the 4 groups. The reversibility of airflow obstruction by beta-2-sympathomimetics (Fenoterol) was the same with or without changes in the sinuses. The atopic trait (RAST or immediate prick tests) or non-atopic asthma was not associated with any sinus abnormalities. In conclusion, if a close association between asthma and radiological disease of the sinuses exists (60% of cases), it does not seem that chronic sinusitis worsens bronchial obstruction or reduces sensitivity to beta-2-sympathomimetics. The changes in the sinus mucosa may be induced by the same aetiologic agent (allergic or non allergic) as asthma.

Adult↗

[Application of computerized tomography to transthoracic puncture].

Transthoracic puncture for peripheral pulmonary lesions not diagnosed by fibroscopy were performed on 70 patients under computed tomographic (CT) control. Sixty four cases had a simple cytological puncture associated in 23 cases with a tru-cut biopsy. Six patients had a needle biopsy. The CT enabled us to localise the tumour to be punctured very accurately, whatever its size or topography in relation to the thoracic wall or mediastinum. It also distinguished necrotic zones within the body of the tumour whose biopsy would lead to false negative results. The sensibility for detecting malign tumours by this method was 83% for cytology and 90% when a biopsy was associated with cytology by needle aspirate. The specificity was 94%. A more precise histological diagnosis was correctly suggested by simple cytology in 7 patients (20%). A tru-cut biopsy enabled histological characterisation in all the neoplastic cases; amongst the benign lesions a specific diagnosis was made on the biopsy in 4 out of 10 cases. There were complications -9% overall. None of the pneumothoraces produced required surgical drainage. There were no fatal complications. In conclusion, transthoracic puncture under CT control is a sensitive method for detecting peripheral malignant tumours and is associated with a low level of complications.

Biopsy, Needle↗

[Pulmonary complications in burn patients and their functional repercussions].

The authors review the literature about respiratory burns and their initial and late functional repercussions. Upper airway oedema induces initial upper airway obstructive impairment. Pulmonary parenchymal failure is characterised by the functional consequences observed with adult respiratory distress syndrome. Survivors may be free of functional impairment. Smoke inhalation syndrome leads to variable airway obstruction resolving usually within 5 months. Persistence of an obstructive impairment may be due to the development of polyposis and/or stenosis in large airways, bronchiolitis obliteration or bronchiectasis.

Airway Obstruction↗